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Development of an image reconstruction algorithm for image improvement of ultra-high spatial resolution SPECT for molecular functional quantitation in a selected small region

Research Project

Project/Area Number 26350558
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Medical systems
Research InstitutionHirosaki University (2016-2017)
National Cardiovascular Center Research Institute (2014-2015)

Principal Investigator

ZENIYA Tsutomu  弘前大学, 理工学研究科, 教授 (50443487)

Co-Investigator(Renkei-kenkyūsha) IIDA Hidehiro  独立行政法人国立循環器病研究センター, 研究所, 部長 (30322720)
WATABE Hiroshi  東北大学, サイクロトロン・ラジオアイソトープセンター, 准教授 (40280820)
HAYASHI Takuya  独立行政法人理化学研究所, ライフサイエンス技術基盤研究センター, ユニットリーダー (50372115)
KUDO Hiroyuki  筑波大学, システム情報工学研究科(系), 教授 (60221933)
HIRANO Yoshiyuki  独立行政法人放射線医学総合研究所, 分子イメージング研究センター, 研究員 (00423129)
KOSHINO Kazuhiro  独立行政法人国立循環器病研究センター, 研究所, 室長 (90393206)
HORI Yuki  独立行政法人国立循環器病研究センター, 研究所, 研究員 (60635887)
MORIGUCHI Tetsuaki  独立行政法人国立循環器病研究センター, 研究所, 研究員 (10635890)
KAWASHIMA Hidekazu  独立行政法人国立循環器病研究センター, 研究所, 室長 (70359438)
SATO Tetsuo  奈良先端科学技術大学院大学, 情報科学研究科, 助教 (90362839)
HASHIKAWA Yoshiko  独立行政法人国立循環器病研究センター, 研究所, 研究員 (20559596)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords医用画像 / 核医学 / SPECT / 画像再構成アルゴリズム / 分子機能 / 高解像度 / ピンホールコリメータ / 医療 / 生体機能 / 放射線 / 画像 / アルゴリズム
Outline of Final Research Achievements

We are developing an ultra-high spatial-resolution pinhole SPECT system to quantify molecular functions in a selected small region. This study aimed to improve distortion, quantitation and spatial resolution of the image generated in this system. First, it was conformed that the used full-digital detector with multiple position-sensitive photomultiplier tubes had high spatial resolution and no image distortion due to noise suppression. Second, the image quantitation was improved by correcting the effects of attenuation and scatter inside the object in pinhole SPECT image reconstruction. Third, the spatial resolution was improved by correcting the effect of the blurring due to collimator aperture. This study promoted the practical use of this SPECT system

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (22 results)

All 2017 2016 2015 2014

All Journal Article (8 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 4 results,  Acknowledgement Compliant: 1 results) Presentation (14 results) (of which Int'l Joint Research: 4 results,  Invited: 1 results)

  • [Journal Article] Multi-pinhole fluorescent x-ray computed tomography for molecular imaging2017

    • Author(s)
      Tenta Sasaya, Naoki Sunaguchi, Kazuyuki Hyodo, Tsutomu Zeniya, Tetsuya Yuasa
    • Journal Title

      Scientific reports

      Volume: 7 Issue: 1 Pages: 5742-5742

    • DOI

      10.1038/s41598-017-05179-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 123I-Labeled oxLDL Is Widely Distributed Throughout the Whole Body in Mice2017

    • Author(s)
      Nakano Atushi、Kawashima Hidekazu、Miyake Yoshinori、Zeniya Tsutomu、Yamamoto Akihide、Koshino Kazuhiro、Temma Takashi、Fukuda Tetsuya、Fujita Yoshiko、Kakino Akemi、Kanaya Shigehiko、Sawamura Tatsuya、Iida Hidehiro
    • Journal Title

      Nuclear Medicine and Molecular Imaging

      Volume: 52 Issue: 2 Pages: 144-153

    • DOI

      10.1007/s13139-017-0497-2

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dual-energy fluorescent x-ray computed tomography system with a pinhole design: Use of K-edge discontinuity for scatter correction2017

    • Author(s)
      T. Sasaya, N. Sunaguchi, Thet-Thet-Lwin, K. Hyodo, T. Zeniya, T. Takeda, and T. Yuasa
    • Journal Title

      Scientific Reports

      Volume: 7 Issue: 1 Pages: 44143-44143

    • DOI

      10.1038/srep44143

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Development of high-resolution brain SPECT system using full-digital gamma camera with multiple position-sensitive PMTs2016

    • Author(s)
      Zeniya T, Gaku K, Hori Y, Koshino K, Sato T, Kanaya S, Iida H
    • Journal Title

      2015 IEEE Nuclear Science Symposium Conference Record

      Volume: -

    • Related Report
      2016 Research-status Report
  • [Journal Article] The need for quantitative SPECT in clinical brain examinations2016

    • Author(s)
      Iida H, Zeniya T, Yamauchi M, Koshino K, Temma T, Iguchi S, Yamazaki M, Enmi J, Kondo N, Motomura N, Nakagawara J
    • Journal Title

      Perspectives on Nuclear Medicine for Molecular Diagnosis and Integrated Therapy

      Volume: - Pages: 17-38

    • DOI

      10.1007/978-4-431-55894-1_2

    • ISBN
      9784431558927, 9784431558941
    • Related Report
      2016 Research-status Report
    • Open Access
  • [Journal Article] Gold nanoparticleを造影剤とするマルチピンホール蛍光X線CTの基礎的検討2016

    • Author(s)
      笹谷典太,砂口尚輝,兵藤一行,銭谷勉,湯浅哲也
    • Journal Title

      電子情報通信学会技術報告

      Volume: 115 Pages: 121-126

    • Related Report
      2015 Research-status Report
  • [Journal Article] EM-TV reconstruction algorithm for pinhole-type fluorescent X-ray computed tomography2015

    • Author(s)
      Sasaya T, Sunaguchi N, Aoki D, Yuasa T, Hyodo K, Zeniya T
    • Journal Title

      Proceedings of 2015 10th Asian Control Conference

      Volume: CD-ROM Pages: 1-6

    • DOI

      10.1109/ascc.2015.7244545

    • NAID

      130005146165

    • Related Report
      2015 Research-status Report
  • [Journal Article] EM-TVアルゴリズムのピンホール型蛍光X線CT再構成への応用2014

    • Author(s)
      笹谷典太,砂口尚輝,青木大,湯浅哲也,兵藤一行,銭谷勉
    • Journal Title

      第57回自動制御連合講演会予稿集

      Volume: CD-ROM Pages: 2018-2023

    • Related Report
      2014 Research-status Report
  • [Presentation] 局所高解像度SPECT画像再構成法のマルチピンホールコリメータへの応用2017

    • Author(s)
      今野 椋太,越野 一博,樋口 隆弘,銭谷 勉
    • Organizer
      平成29年度電気関係学会東北支部連合大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Non-invasive measurement of delayed nerve damage in a hypoxic-ischemic encephalopathy rat model using 15O-labeled gas positron emission tomography and magnetic resonance imaging2016

    • Author(s)
      Yamazaki M, Tsuji M, Moriguchi T, Temma T, Koshino K, Zeniya T, Iida H
    • Organizer
      World Molecular Imaging Congress 2016
    • Place of Presentation
      New York, USA
    • Year and Date
      2016-09-07
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Reduction of camera-specific variability in [123I]FP-CIT SPECT by image reconstruction optimized for multi-site settings: Experimental validation and the value of using [123]I-specific collimator2016

    • Author(s)
      Iida H, Zeniya T, Motomura N, Nakagawara J
    • Organizer
      Society of Nuclear Medicine and Molecular Imaging 2016 Annual Meeting
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2016-06-11
    • Related Report
      2016 Research-status Report
    • Int'l Joint Research
  • [Presentation] Gold nanoparticleを造影剤とするマルチピンホール蛍光X線CTの基礎的検討2016

    • Author(s)
      笹谷典太,砂口尚輝,兵藤一行,銭谷勉,湯浅哲也
    • Organizer
      電子情報通信学会医用画像研究会
    • Place of Presentation
      那覇,那覇市ぶんかテンブス館
    • Year and Date
      2016-01-19
    • Related Report
      2015 Research-status Report
  • [Presentation] QSPECT用コリメータ開口補正の開発と評価2015

    • Author(s)
      銭谷勉,越野一博,井口智史,圓見純一郎,山崎真,天滿敬,飯田秀博
    • Organizer
      第55回日本核医学会学術総会
    • Place of Presentation
      東京,ハイアットリージェンシー東京
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Presentation] 123I-FPCITとSPECTを使った特異的結合比(SBR)-定量精度と施設間再現性確保の試み-2015

    • Author(s)
      飯田秀博,銭谷勉,本村信篤,中川原譲二
    • Organizer
      第55回日本核医学会学術総会
    • Place of Presentation
      東京,ハイアットリージェンシー東京
    • Year and Date
      2015-11-05
    • Related Report
      2015 Research-status Report
  • [Presentation] Development of high-resolution brain SPECT system using full-digital gamma camera with multiple position-sensitive PMTs2015

    • Author(s)
      Zeniya T, Gaku K, Hori Y, Koshino K, Sato T, Kanaya S, Iida H
    • Organizer
      2015 IEEE Nuclear Science Symposium and Medical Imaging Conference
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2015-10-31
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] DaTSCAN定量SPECTイメージングにおける定量精度確保と施設間誤差の最小化2015

    • Author(s)
      飯田秀博,銭谷勉,本村信篤,中川原譲二
    • Organizer
      第27回日本脳循環代謝学会総会
    • Place of Presentation
      富山、富山国際会議場
    • Year and Date
      2015-10-30
    • Related Report
      2015 Research-status Report
  • [Presentation] 生体計測のためのマルチピンホール蛍光X線CT2015

    • Author(s)
      笹谷典太,砂口尚輝,室塚 誠,兵藤一行,銭谷勉,湯浅哲也
    • Organizer
      第32回センシングフォーラム 計測部門大会
    • Place of Presentation
      寝屋川,大阪電気通信大学寝屋川キャンパス
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 小動物用SPECT装置2015

    • Author(s)
      銭谷勉
    • Organizer
      第11回小動物インビボイメージング研究会
    • Place of Presentation
      岡山,岡山大学
    • Year and Date
      2015-07-25
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] EM-TV reconstruction algorithm for pinhole-type fluorescent X-ray computed tomography2015

    • Author(s)
      Sasaya T, Sunaguchi N, Aoki D, Yuasa T, Hyodo K, Zeniya T
    • Organizer
      10th Asian Control Conference 2015
    • Place of Presentation
      Kota Kinabalu, Malaysia
    • Year and Date
      2015-05-31
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Presentation] 3D脳ファントムを用いたSPECT空間解像度の推定2015

    • Author(s)
      銭谷勉,堀祐樹,越野一博,井口智史,圓見純一郎,山崎真,天滿敬,山本明秀,山内美穂,飯田秀博
    • Organizer
      日本分子イメージング学会第10回総会・学術集会
    • Place of Presentation
      東京,タワーホール船堀
    • Year and Date
      2015-05-20 – 2015-05-21
    • Related Report
      2014 Research-status Report
  • [Presentation] EM-TVアルゴリズムのピンホール型蛍光X線CT再構成への適用2014

    • Author(s)
      笹谷典太,砂口尚輝,青木大,湯浅哲也,兵藤一行,銭谷勉
    • Organizer
      第57回自動制御連合講演会
    • Place of Presentation
      群馬伊香保,ホテル天坊
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Image improvement of by collimator aperture correction in quantitative SPECT imaging2014

    • Author(s)
      Zeniya T, Koshino k< Moriguchi T, Enmi J, Iguchi S, Yamamoto A, Iida H
    • Organizer
      World Molecular Imaging Congress 2014
    • Place of Presentation
      Seoul, Korea
    • Year and Date
      2014-09-17 – 2014-09-20
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2019-03-29  

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