| Project/Area Number |
26350566
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Rehabilitation science/Welfare engineering
|
|---|
| Research Institution | Tottori University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
加藤 雅彦 鳥取大学, 医学部, 准教授 (40362884)
山本 一博 鳥取大学, 医学部, 教授 (90303966)
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
|---|
| Keywords | 呼吸筋 / HFpEF / 拡張不全 |
|---|
| Outline of Final Research Achievements |
We examined the relationship between inspiratory muscle weakness (IMW) and exercise intolerance in 40 patients with Heart failure with preserved ejection fraction (HFpEF). IMW was prevalent in 27.5% of patients. Patients with IMW had significantly lower percent vital capacity to normal predicted values (%VC), lower percent knee extensor muscle strength to body weight (%KEMS), and shorter 6-minute walk distance (6-MWD) compared with patients without IMW (all p<0.05). Subgroup analysis showed that IMW was accompanied by a further decrease in 6-MWD in patients with restrictive pulmonary dysfunction (%VC <80%) or lower-limb muscle weakness (median value: %KEMS <30%) (all p<0.05). We concluded that IMW was an additional factor implicated in exercise intolerance in patients with HFpEF, and respiratory muscle training is a potential beneficial intervention in those patients.
|
