Assessment of Whole Blood Rheology and Leukocyte Activity in ex vivo Microchannel Array Model to Contribute Cardiovascular Rehabilitation Research
Project/Area Number |
26350581
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Dokkyo Medical University |
Principal Investigator |
YASU TAKANORI 獨協医科大学, 医学部, 教授 (40265278)
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Co-Investigator(Kenkyū-buntansha) |
秦 信宏 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 (50357779)
大屋 祐輔 琉球大学, 医学(系)研究科(研究院), 教授 (30240964)
渡邊 裕也 京都学園大学, バイオ環境学部, 客員研究員 (70644376)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | 微小循環 / 血液流動性 / リハビリテーション / 運動 / 抹消動脈疾患 / 白血球 / 末梢動脈疾患 / リハビリテーション |
Outline of Final Research Achievements |
Leucocytes play an important role in the all process of the atherosclerosis. However, clinically feasible parameters of leukocyte activation in microcirculation is limited. We developed a clinically feasible assessment method of leukocyte activity and blood rheology using a microchannel flow analyzer (MCFAN) with new designed silicon chips mimic to human microvascular network. The passage time of whole blood with heparin or EDTA-2Na+heparin through the microchannel arrays was measured using MC-FAN. Number of adhesive leukocytes (/field) was counted in offline as a gold standard of leukocyte activation. Subtraction of the passage time of blood with heparin and one with EDTA-2Na + heparin was significantly correlated with adhesive leukocyte number. The delta whole blood passage time may be a novel parameter reflecting leukocyte activity.
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Report
(4 results)
Research Products
(117 results)
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[Journal Article] Effects of Pitavastatin on Walking Capacity and CD34+/133+ Cell Number in Patients with Peripheral Artery Disease.2017
Author(s)
Arao K, Yasu T, Endo Y, Funazaki T, Ota Y, Shimada K, Tokutake E, Naito N, Takase B, Wake M, Ikeda N, Horie Y, Sugimura H, Momomura S, Kawakami M.
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Journal Title
Heart and Vessels
Volume: in press
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Improvement of congestive heart failure after adaptive servo-ventilation in a patient with end-stage renal disease on hemodialysis: a case report.2014
Author(s)
Aizawa N, Nagahama K, Goya K, Yamazato S, Ikemiyagi H, Oshiro K, Shinzato T, Higashiuesato Y, Ishiki T, Yasu T, Iseki K, Ohya Y
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Journal Title
Intern Med
Volume: 53
Pages: 2087-2090
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Peer Reviewed
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[Presentation] Effect of GLP-1 receptor agonist on digestive tract movement evaluation using capsule endoscopy.2016
Author(s)
Y. Nakatani, M Maeda, Y Majima, N. Domeki, Y. Miyashita, M. Matsumura, Y. Aso, N. Banba, T. Yasu, H. Harasawa, T. Nakamoto
Organizer
52nd European Association for the Study of Diabetes
Place of Presentation
MEO Arena(Munich Germany)
Year and Date
2016-09-15
Related Report
Int'l Joint Research
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[Presentation] 心臓リハビリテーションにおける大腿筋超音波筋輝度測定の意義2016
Author(s)
永坂優美,田村由馬,江原恭介,落合香,須藤誠,高橋英里,藤原智亜紀,上野明日香,浅田宏史,中元隆明,安隆則
Organizer
第22回心臓リハビリテーション学会学術集会
Place of Presentation
東京国際フォーラム(東京都千代田区)
Year and Date
2016-07-17
Related Report
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[Presentation] 受動的負荷方法による呼気ガス分析の検討2016
Author(s)
田村由馬,浅田宏史,永坂優美,江原恭介,落合香,高橋英里,藤原智亜紀,上野明日香,中元隆明,安隆則
Organizer
第22回心臓リハビリテーション学会学術集会
Place of Presentation
東京国際フォーラム(東京都千代田区)
Year and Date
2016-07-16
Related Report
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[Presentation] 積極的運動療法が困難な末梢動脈疾患3例に対するベルト式骨格筋電気刺激の有効性2016
Author(s)
落合香,田村由馬,永坂優美,江原恭介,須藤誠,高橋英里,藤原智亜紀,上野明日香,浅田宏史,中元隆明,安隆則
Organizer
第22回心臓リハビリテーション学会学術集会
Place of Presentation
東京国際フォーラム(東京都千代田区)
Year and Date
2016-07-16
Related Report
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[Presentation] 末梢動脈疾患患者へのバイブラバス使用による運動療法相加効果2016
Author(s)
江原恭介,田村由馬,高橋英里,落合香,藤原智亜紀,須藤誠,永坂優美,上野明日香,清水理葉,杉村浩之,中元隆明,安隆則
Organizer
第22回心臓リハビリテーション学会学術集会
Place of Presentation
東京国際フォーラム(東京都千代田区)
Year and Date
2016-07-16
Related Report
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[Presentation] Clinical Background of the Non-Responder to Exercise Therapy of Patients with Chronic Heart Failure.2014
Author(s)
A Kuribara, C Fujiwara, A Kawabe, T Sugiyama, T Toi, M Shimoyama, Y Horie, T Hoshi, H Sugimura, T Nakamoto, T Yasu.
Organizer
5th Asian Preventive Cardiology and Cardiac Rehabilitation Conference
Place of Presentation
Hong Kong
Year and Date
2014-11-08
Related Report
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