| Project/Area Number |
26350581
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Dokkyo Medical University |
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Principal Investigator |
YASU TAKANORI 獨協医科大学, 医学部, 教授 (40265278)
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| Co-Investigator(Kenkyū-buntansha) |
秦 信宏 国立研究開発法人産業技術総合研究所, その他部局等, 研究員 (50357779)
大屋 祐輔 琉球大学, 医学(系)研究科(研究院), 教授 (30240964)
渡邊 裕也 京都学園大学, バイオ環境学部, 客員研究員 (70644376)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 微小循環 / 血液流動性 / リハビリテーション / 運動 / 抹消動脈疾患 / 白血球 / 末梢動脈疾患 / ﾘﾊﾋﾞﾘﾃｰｼｮﾝ |
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| Outline of Final Research Achievements |
Leucocytes play an important role in the all process of the atherosclerosis. However, clinically feasible parameters of leukocyte activation in microcirculation is limited. We developed a clinically feasible assessment method of leukocyte activity and blood rheology using a microchannel flow analyzer (MCFAN) with new designed silicon chips mimic to human microvascular network. The passage time of whole blood with heparin or EDTA-2Na+heparin through the microchannel arrays was measured using MC-FAN. Number of adhesive leukocytes (/field) was counted in offline as a gold standard of leukocyte activation. Subtraction of the passage time of blood with heparin and one with EDTA-2Na + heparin was significantly correlated with adhesive leukocyte number. The delta whole blood passage time may be a novel parameter reflecting leukocyte activity.
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