The functional gait recovery with transcutaneous spinal afferent stimulation among patients with stroke

• Project/Area Number: 26350587
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Juntendo University (2016); Tokai University (2014-2015)
• Principal Investigator: FUJIWARA Toshiyuki 順天堂大学, 医学部, 教授 (50276375)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: リハビリテーション医学 / 歩行 / 脳卒中 / 電気刺激 / 脊髄刺激 / 相反性抑制 / 脊髄反射 / 歩行障害 / リハビリテーション

Outline of Final Research Achievements

We developed newly transcutaneous spinal stimulation (TSS) system. We applied spinal stimulation for gait restoration among patients with stroke. The spinal stimulation was triggered by muscle activity of unaffected soleus muscle during locomotion. Gait training with TSS improved 10m walk test and symmetricity of locomotion. it was supposed our newly developed TSS system combined with gait training may effective to improve gait function.

Research Products

• [Journal Article] Hybrid Assistive Neuromuscular Dynamic Stimulation Therapy: A new strategy for improving upper extremity function in patients with hemiparesis following stroke (2017)
  • Author(s): Fujiwara T, Kawakami M, Honaga K, Tochikura M, Abe K
  • Journal Title: Neural Plasticity Volume: 2350137 Pages: 1-5
  • DOI: 10.1155/2017/2350137
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A new therapeutic application of brain-machine interface (BMI) training followed by hybrid assistive neuromuscular dynamic stimulation (HANDS) therapy for patients with severe hemiparetic sstroke: A proof of concept study. (2016)
  • Author(s): Kawakami M, Fujiwara T, Ushiba J, Nishimoto A, Abe K, Honaga K, Nishimura A, Mizuno K, Kodama M, Masakado Y, Liu M
  • Journal Title: Restor Neurol Neurosc Volume: ３４ Issue: 5 Pages: 789-79
  • DOI: 10.3233/rnn-160652
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] The effect of anodal transcranial direct current stimulation and patterned electrical stimulation on spinal inhibitory interneurons and motor function in patients with spinal cord injury. (2016)
  • Author(s): Yamaguchi T, Fujiwara T, Tsai YA, Tang SC, Kawakami M, Mizuno K, Kodama M, Masakado Y, Liu M
  • Journal Title: Exp Brain Res Volume: in press Issue: 6 Pages: 1469-1478
  • DOI: 10.1007/s00221-016-4561-4
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] 脳卒中のリハビリテーション (2014)
  • Author(s): 藤原俊之
  • Journal Title: Jpn J Rehabil Med Volume: 52 Pages: 20-23
• [Presentation] 脳卒中片麻痺患者における脊髄電気刺激を用いた歩行機能再建 (2016)
  • Author(s): 藤原俊之
  • Organizer: 第46回 日本臨床神経生理学会
  • Place of Presentation: 郡山 ホテルハマツ
  • Year and Date: 2016-10-27
  • Invited
• [Presentation] : Hybrid Assistive Neuromuscular Dynamic Stimulation (HANDS) therapy-New sthrapeutic strategy for hemiparetic upper extremity aftr stroke. Non-invasive brain and nerve stimulation for health and neurological disorders (2016)
  • Author(s): Fujiwara T
  • Organizer: 第10回 International Conference on Complex Medical Engineering
  • Place of Presentation: Utsunomiya Tochigi culture center
  • Year and Date: 2016-08-04
  • Int'l Joint Research / Invited
• [Presentation] 脳卒中治療ガイドラインから読み解く新しい脳卒中リハビリテーションの流れ (2016)
  • Author(s): 藤原俊之
  • Organizer: 第53回 日本リハビリテーション医学会学術集会
  • Place of Presentation: 京都 京都国際会議場
  • Year and Date: 2016-06-09
  • Invited
• [Presentation] HANDS therapy (2016)
  • Author(s): Fujiwara T
  • Organizer: 第10回 International Society of Physical & Rehabilitation Medicine
  • Place of Presentation: Kuara Lumpur Malaysia convention and exhibition bureu
  • Year and Date: 2016-05-31
  • Int'l Joint Research / Invited
• [Presentation] 脳卒中後運動機能障害に対する新しいリハビリテーション (2016)
  • Author(s): 藤原俊之
  • Organizer: 第1回 桜山リハビリテーション研究会
  • Place of Presentation: 電気文化会館（愛知県名古屋市）
  • Year and Date: 2016-03-26
  • Invited
• [Presentation] 脳卒中治療ガイドライン2015から読み解く新しい脳卒中リハビリテーションの流れ (2016)
  • Author(s): 藤原俊之
  • Organizer: 第2回 京都リハビリテーション医学研究会
  • Place of Presentation: 京都国際会議場（京都府京都市）
  • Year and Date: 2016-02-07
  • Invited
• [Presentation] 脳卒中リハビリテーションの新しい流れ (2016)
  • Author(s): 藤原俊之
  • Organizer: 第64回 日本リハビリテーション医学会関東地方会
  • Place of Presentation: 新潟 新潟医療人育成センター
  • Invited
• [Presentation] 脳卒中片麻痺上肢機能障害障害に対するHANDS therapy. リハビリテーション最先端～先端的治療法による臨床の実際～ (2015)
  • Author(s): 藤原俊之
  • Organizer: 第33回 日本神経治療学会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市）
  • Year and Date: 2015-11-26
  • Invited
• [Presentation] 歩行機能再建への新たな試み (2015)
  • Author(s): 藤原俊之
  • Organizer: 第50回 日本脊髄障害医学会
  • Place of Presentation: グランドプリンスホテル高輪（東京都品川区）
  • Year and Date: 2015-11-19
  • Invited
• [Presentation] 歩行機能再建への新たな試み―Functional Assistive Stimulation (FAST) walk. 脳力を活かす革新的ニューロリハビリテーション. (2015)
  • Author(s): 藤原俊之
  • Organizer: 第45回 日本臨床神経生理学会
  • Place of Presentation: 大阪国際会議場（大阪府大阪市）
  • Year and Date: 2015-11-05
  • Invited
• [Presentation] New therapeutic strategy for upper extremity motor function after stroke-HANDS therapy. Post stroke motor rehabilitation (2015)
  • Author(s): Toshiyuki Fujiwara
  • Organizer: 第1回 Asia-Oceanian Congress for Neurorehabilitation
  • Place of Presentation: Grand Hilton (Seoul、Korea）
  • Year and Date: 2015-09-03
  • Int'l Joint Research
• [Presentation] Hybrid Assistive Neuromuscular Dynamic stimulation (HANDS) therapy - new therapeutic strategy for hemiparetic upper extremity after stroke. Recent advances in neurorehabilitation based on neuroscience (2015)
  • Author(s): Toshiyuki Fujiwara
  • Organizer: 第38回 日本神経科学大会
  • Place of Presentation: 神戸コンベンションセンター（兵庫県神戸市）
  • Year and Date: 2015-07-27
  • Invited
• [Presentation] QPS for stroke patients (2015)
  • Author(s): Toshiyuki Fujiwara
  • Organizer: International Symposium on Magnetic Stimulation
  • Place of Presentation: 東京大学（東京都文京区）
  • Year and Date: 2015-06-06
  • Int'l Joint Research / Invited
• [Presentation] 脳卒中リハビリテーションの新しい流れ (2015)
  • Author(s): 藤原俊之
  • Organizer: 第52回 日本リハビリテーション医学会学術集会
  • Place of Presentation: 朱鷺メッセ（新潟県新潟市）
  • Year and Date: 2015-05-27
  • Invited
• [Presentation] Hybrid Assistive Neuromuscular Dynamic Stimulation (HANDS) therapy. 有効な中枢性運動麻痺治療方法 (2015)
  • Author(s): 藤原俊之
  • Organizer: 第29回 日本医学会総会
  • Place of Presentation: 国立京都国際会館（京都府京都市）
  • Year and Date: 2015-04-12
  • Invited
• [Presentation] The mechanism of functional recovery of upper extremity motor function among patients with stroke: Moduation of cortical and spinal interneuron (2015)
  • Author(s): Toshiyuki Fujiwara
  • Organizer: 第４２回日本脳卒中学会
  • Place of Presentation: 広島
  • Year and Date: 2015-03-26
  • Invited
• [Presentation] The mechanism of functional recovery of upper extremity motor function among patients with stroke: Moduation of cortical and spinal interneuron (2015)
  • Author(s): Toshiyuki Fujiwara
  • Organizer: 1st International Brain Stimualtion Conference
  • Place of Presentation: Singapore
  • Year and Date: 2015-03-02 – 2015-03-04
• [Presentation] 脳卒中片麻痺に対する新しいと医療戦略 (2014)
  • Author(s): 藤原俊之
  • Organizer: 日本運動療法学会
  • Place of Presentation: 千葉
  • Year and Date: 2014-06-21
  • Invited
• [Presentation] 脳卒中のリハビリテーション (2014)
  • Author(s): 藤原俊之
  • Organizer: 第51回日本リハビリテーション医学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-06-07
  • Invited
• [Presentation] 痙縮治療のエビデンス (2014)
  • Author(s): 藤原俊之
  • Organizer: 第51回日本リハビリテーション医学会学術集会
  • Place of Presentation: 名古屋
  • Year and Date: 2014-06-06
  • Invited
• [Book] 脳卒中片麻痺上肢の新しい治療戦略 HANDS therapy (2015)
  • Author(s): 藤原俊之 阿部 薫
  • Total Pages: 60
  • Publisher: 医歯薬出版
• [Remarks] 脳卒中片麻痺患者歩行障害に対する経皮的脊髄電気刺激による歩行機能再建
  • URL: http://www.tokai-reha.com/medicine/scs.htm
• [Remarks] 東海大学医学部専門診療学系リハビリテーション科学 先端医療 脊髄刺激
  • URL: http://www.tokai-reha.com/medicine/scs.htm
• [Patent(Industrial Property Rights)] 歩行訓練用脊髄電気刺激装置 (2015)
  • Inventor(s): 藤原俊之
  • Industrial Property Rights Holder: 藤原俊之
  • Industrial Property Rights Type: 特許
  • Industrial Property Number: 2015-051122
  • Filing Date: 2015-03-13