| Project/Area Number |
26350588
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Juntendo University |
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Principal Investigator |
Shimada Kazunori 順天堂大学, 医学(系)研究科(研究院), 先任准教授 (60327814)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Yoshifumi 順天堂大学, 大学院 医学研究科, 准教授 (80420834)
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| Research Collaborator |
YAMASHITA Haruyo 順天堂大学, 大学院 医学研究科, 助教 (90534892)
SAI Eiryu 順天堂大学, 大学院 医学研究科, 助教 (30747415)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 心筋内中性脂肪 / 異所性脂肪 / 心筋MRS法 / 心臓リハビリテーション / MRS法 / MRスペクトロスコピー / 異所性脂肪蓄積 / 肥大型心筋症 / 高血圧性心疾患 |
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| Outline of Final Research Achievements |
Proton magnetic resonance spectroscopy (1H-MRS) enables to assess ectopic fat. We evaluated myocardial triglyceride (MTG) content measured by 1H-MRS in apparently healthy subjects and patients with left ventricular (LV) hypertrophy. The mean MTG content was 0.85% in healthy subjects. The MTG content was significantly associated with the percent body fat and serum TG, anaerobic threshold, and LV end-systolic volume. The MTG content was significantly higher in the hypertensive heart disease (HHD) group than in the hypertrophic cardiomyopathy (HCM) group. In a multivariate analysis, LV mass volume and diagnosis of HCM or HHD were independent factors of the MTG content. Cardiac rehabilitation could reduce MTG content. 1H-MRS may be useful for assessing the associations between the MTG content and various clinical parameters, including those reflecting obesity, metabolic disorders, cardiac morphology and exercise capacity, noninvasively.
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