| Project/Area Number |
26350594
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tokoha University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
TSUTSUI Yoshihiro 常葉大学, 保健医療学部, 教授 (50073135)
AGATA Nobuhide 常葉大学, 保健医療学部, 講師 (00549313)
UMEMURA Kazuo 浜松医科大学, 医学部, 教授 (40232912)
HOKAMURA Kazuya 浜松医科大学, 医学部, 教授 (90436965)
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| Research Collaborator |
MORISHITA Saho 常葉大学, 健康プロデュース学部, 助手 (30614010)
YOSHIKAWA Akira 昭和大学, 医学部, 助教 (90737355)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 脳梗塞モデル動物 / 運動負荷 / 神経再構築 / 脳梗塞モデル / リハビリテーション / 脳梗塞 / 神経新生 |
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| Outline of Final Research Achievements |
Although exercise therapies in the rehabilitation can promote motor recovery after cerebral infarction, the neurologic mechanism underlying them remained largely unknown. As exercise affects neurogenesis in adult brain, we examined the role of different types of exercises on the generation and lineage of neural stem cells (especially GABAergic cells) and motor recovery using the motor cortex stroke rats. Conventional motor analysis failed to detect the functional recovery during recovery period.. However, beam-walking tests with minor modifications enables us to reveal in gait deficits and show the significant effect on exercises on promotion of motor recovery. To evaluate de novo neurogenesis, we have performed lineage analysis of newly-generating neural stem cells using BrdU labeling and immunohistochemnistry. Although BrdU(+) cells were increased in stroke rats, these are appeared not to become some subpopulation of GABAergic cells.
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