The roles of exercises on motor recovery and neuronal reorganization reltated with GABA systems in the focal motor stroke rats
Project/Area Number |
26350594
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Rehabilitation science/Welfare engineering
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Research Institution | Tokoha University |
Principal Investigator |
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Co-Investigator(Renkei-kenkyūsha) |
TSUTSUI Yoshihiro 常葉大学, 保健医療学部, 教授 (50073135)
AGATA Nobuhide 常葉大学, 保健医療学部, 講師 (00549313)
UMEMURA Kazuo 浜松医科大学, 医学部, 教授 (40232912)
HOKAMURA Kazuya 浜松医科大学, 医学部, 教授 (90436965)
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Research Collaborator |
MORISHITA Saho 常葉大学, 健康プロデュース学部, 助手 (30614010)
YOSHIKAWA Akira 昭和大学, 医学部, 助教 (90737355)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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Keywords | 脳梗塞モデル動物 / 運動負荷 / 神経再構築 / 脳梗塞モデル / リハビリテーション / 脳梗塞 / 神経新生 |
Outline of Final Research Achievements |
Although exercise therapies in the rehabilitation can promote motor recovery after cerebral infarction, the neurologic mechanism underlying them remained largely unknown. As exercise affects neurogenesis in adult brain, we examined the role of different types of exercises on the generation and lineage of neural stem cells (especially GABAergic cells) and motor recovery using the motor cortex stroke rats. Conventional motor analysis failed to detect the functional recovery during recovery period.. However, beam-walking tests with minor modifications enables us to reveal in gait deficits and show the significant effect on exercises on promotion of motor recovery. To evaluate de novo neurogenesis, we have performed lineage analysis of newly-generating neural stem cells using BrdU labeling and immunohistochemnistry. Although BrdU(+) cells were increased in stroke rats, these are appeared not to become some subpopulation of GABAergic cells.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] The role of calcium and cyclic nucleotide signaling in cerebellar granule cell migration under normal and pathological conditions.2015
Author(s)
Komuro, Y., Galas, L., Lebon, A., Raoult, E., Fahrion, J. K., Tilot, A., Kumada, T., Ohno, N., Vaudry, D., and Komuro, H.
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Journal Title
Dev Neurobiol
Volume: 75
Issue: 4
Pages: 369-387
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Ion channels, guidance molecules, intracellular signaling and transcription factors regulating nervous and vascular system development.2015
Author(s)
Akita, T., Kumada, T., Yoshihara, S. I., Egea, J., and Yamagishi, S.
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Journal Title
J Physiol Sci.
Volume: 66
Issue: 2
Pages: 175-188
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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