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Effectiveness of pharmacotherapy in stroke rehabilitation and identification of functional molecules implicated neuronal plasticity

Research Project

Project/Area Number 26350596
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionFujita Health University

Principal Investigator

Mizutani Kenmei  藤田保健衛生大学, 藤田記念七栗研究所, 講師 (30351068)

Co-Investigator(Kenkyū-buntansha) 園田 茂  藤田保健衛生大学, 医学部, 教授 (10197022)
脇田 英明  藤田保健衛生大学, 医学部, 教授 (80416172)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords脳梗塞 / リハビリテーション / 神経可塑性 / 薬物併用療法 / 機能回復 / セロトニン / 薬剤併用療法
Outline of Final Research Achievements

Recently, it has become widely known that neuronal reorganization in the perilesional cortex contributes to some improvement of hemiparesis after stroke. Therefore, various new treatments have been developed to aid in paralysis recovery. Here, we examined in vivo the effects of administration of an activator of protein kinase C (PKC), combined with exercise on functional recovery. The combination of exercise and PKC activator induced further functional recovery compared with exercise alone, and the behavioral effect seen in the administrated animals was dose dependent. Moreover, combining exercise with administration led to increased phosphorylated proteins and serotonin in the perilesional cortex.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 2015 2014

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 3 results,  Open Access: 1 results) Presentation (5 results)

  • [Journal Article] Improvement in trunk tremor by forced gait training in cerebellar ataxic Wob/t mice.2017

    • Author(s)
      Beppu H, Takeda K, Tomita Y, Orand A, Mizutani K, Tamai I, Takayanagi N, Takahashi H, Sonoda S.
    • Journal Title

      Structure and Function

      Volume: 15 Pages: 62-70

    • NAID

      130005634024

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of exercise and bryostatin-1 on serotonin dynamics after cerebral infarction.2016

    • Author(s)
      Mizutani K, Sonoda S, Wakita H, Okazaki H, Katoh Y, Chihara T, Shimpo K.
    • Journal Title

      Neuroreport

      Volume: 27 Issue: 9 Pages: 659-664

    • DOI

      10.1097/wnr.0000000000000592

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of exercise and bryostatin-1 on serotonin dynamics after cerebral infarction2016

    • Author(s)
      Mizutani K, Sonoda S, Wakita H, Okazaki H, Katoh Y, Chihara T, Shimpo K.
    • Journal Title

      NeuroReport

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Effects of occlusal disharmony on the hippocampal dentate gyrus in aged senescence-accelerated mouse prone 8 (SAMP8).2016

    • Author(s)
      Mori D, Miyake H, Mizutani K, Shimpo K, Sonoda S, Yamamoto T, Fujiwara S, Kubo KY.
    • Journal Title

      Arch Oral Biol.

      Volume: 65 Pages: 95-101

    • DOI

      10.1016/j.archoralbio.2016.01.015

    • Related Report
      2015 Research-status Report
    • Peer Reviewed
  • [Journal Article] Hippocampus-dependent spatial memory impairment due to molar tooth loss is ameliorated by an enriched environment.2016

    • Author(s)
      Kondo H, Kurahashi M, Mori D, Iinuma M, Tamura Y, Mizutani K, Shimpo K, Sonoda S, Azuma K, Kubo KY.
    • Journal Title

      Arch Oral Biol.

      Volume: 61 Pages: 1-7

    • DOI

      10.1016/j.archoralbio.2015.10.006

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein kinase C activator, bryostatin-1, promotes exercise-dependent functional recovery in rats with cerebral infarction2015

    • Author(s)
      Mizutani K, Sonoda S, Wakita H, Shimpo K
    • Journal Title

      Am J Phys Med Rehabil

      Volume: 94 Issue: 3 Pages: 239-243

    • DOI

      10.1097/phm.0000000000000227

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Changes in Serum Growth Factors in Stroke Rehabilitation Patients and Their Relation to Hemiparesis Improvement.2014

    • Author(s)
      Okazaki H, Beppu H, Mizutani K, Okamoto S, Sonoda S.
    • Journal Title

      J Stroke Cerebrovasc Dis

      Volume: 23 Issue: 6 Pages: 1703-1708

    • DOI

      10.1016/j.jstrokecerebrovasdis.2014.01.015

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Presentation] 脳梗塞後の麻痺回復におけるモノアミンの役割2016

    • Author(s)
      水谷謙明、園田茂、別府秀彦
    • Organizer
      第121回日本解剖学会総会・全国学術集会
    • Place of Presentation
      福島県郡山市ビッグパレットふくしま
    • Year and Date
      2016-03-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 脳梗塞ラットへの訓練・薬剤併用療法の可能性と脳内変化.2016

    • Author(s)
      水谷謙明, 園田茂, 武田湖太郎.
    • Organizer
      第23回脳機能とリハビリテーション研究会学術集会
    • Place of Presentation
      千葉県立保健医療大学
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳梗塞ラットへのリタンセリン投与が機能回復に与える影響.2016

    • Author(s)
      水谷謙明, 園田茂, 別府秀彦.
    • Organizer
      第7回日本ニューロリハビリテーション学会学術集会
    • Place of Presentation
      神戸国際会議場
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脳梗塞ラットへの訓練・薬剤併用療法がモノアミン動態に与える影響2015

    • Author(s)
      水谷 謙明, 園田 茂, 別府 秀彦.
    • Organizer
      第6回日本ニューロリハビリテーション学会学術集会
    • Place of Presentation
      秋田県, 秋田ビューホテル
    • Year and Date
      2015-02-21 – 2015-02-22
    • Related Report
      2014 Research-status Report
  • [Presentation] 回復期リハビリテーション患者の入院および退院に関連する血中遊離アミノ酸の検索の試み2015

    • Author(s)
      別府 秀彦, 岡崎英人, 玉井育子, 水谷謙明, 宮坂裕之, 谷野元一, 新保寛, 園田茂.
    • Organizer
      第6回日本ニューロリハビリテーション学会学術集会
    • Place of Presentation
      秋田県, 秋田ビューホテル
    • Year and Date
      2015-02-21 – 2015-02-22
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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