Exercise inhibits neural apoptosis and improves cerebral function following aged rat traumatic brain injury

• Project/Area Number: 26350597
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Kindai University
• Principal Investigator: ITOH Tatsuki 近畿大学, 農学部, 教授 (40330245)
• Co-Investigator(Kenkyū-buntansha): 井上 敬夫 近畿大学, 医学部, 助教 (00441006) ; 佐藤 隆夫 近畿大学, 医学部附属病院, 教授 (70162443)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 高齢者 / リハビリテーション / 神経再生 / 脳外傷 / 高次脳機能改善 / 運動 / 神経再生促進 / 神経再生促進効果

Outline of Final Research Achievements

We investigate the effect of exercise on omorphology and cerebral function following traumatic brain injury(TBI) in aged (two years old) rats. Aged wistar rats received TBI by a pneumatic controled injury device and were randomly divided into two groups :1)non-exercise group and 2) exercise group.The exercise groupran on a treadmill.Immunohistochemical and behavioral studied were permormed follwowing TBI. The number of apoptosis cells early after TBI was significantly rediced in the aged exercise group. Furthermore, most apoptosis cells in the non-exercise group indicated neuronal cells. However, in the exercise group, few apoptosis cells shown. In addition, there was a significant inmprovement in cerebral dysfunction after TBI in the exercise group. These resuls indicate that aged person exercise follwoing TBI inhibits neuronal apoptotic neuronal cell death, which results in an improvement of cerebral dysfunction.

Research Products

• [Journal Article] Statins inhibited the MIP-1α expression via inhibition of Ras/ERK and Ras/Akt pathways in myeloma cells. (2016)
  • Author(s): Tsubaki M, Mashimo K, Takeda T, Kino T, Fujita A, Itoh T, Imano M, Sakaguchi K, Satou T, Nishida S.
  • Journal Title: Biomed Pharmacother. Volume: 78 Pages: 23-29
  • DOI: 10.1016/j.biopha.2015.12.017
  • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Mangiferin enhances the sensitivity of human multiple myeloma cells to anticancer drugs through suppression of the nuclear factor κB pathway (2016)
  • Author(s): Takeda T, Tsubaki M, Kino T, Kawamura A, Isoyama S, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S
  • Journal Title: Int J Oncol Volume: 48 Issue: 6 Pages: 303-309
  • DOI: 10.3892/ijo.2016.3470
  • Peer Reviewed / Open Access
• [Journal Article] A phase II trial of perioperative chemotherapy involving a single intraperitoneal administration of paclitaxel followed by sequential S-1 plus intravenous paclitaxel for serosa-positive gastric cancer (2015)
  • Author(s): Peng YF, Imano M, Itoh T, Satoh T, Chiba Y, Imamoto H, Tsubaki M, Nishida S, Yasuda T, Furukawa H
  • Journal Title: J Surg Oncol Volume: 111 Issue: 8 Pages: 1041-1046
  • DOI: 10.1002/jso.23928
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Mangiferin suppresses CIA by suppressing the expression of TNF-α, IL-6, IL-1β, and RANKL through inhibiting the activation of NF-κB and ERK1/2. (2015)
  • Author(s): Tsubaki M, Takeda T, Kino T, Itoh T, Imano M, Tanabe G, Muraoka O, Satou T, Nishida S
  • Journal Title: Am J Transl Res Volume: 7 Pages: 1371-1381
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Statins improve survival by inhibiting spontaneous metastasis and tumor growth in a mouse melanoma model (2015)
  • Author(s): Tsubaki M, Takeda T, Kino T, Obata N, Itoh T, Imano M, Mashimo K, Fujiwara D, Sakaguchi K, Satou T, Nishida S
  • Journal Title: Am J Cancer Res Volume: 5 Pages: 3186-3197
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Nitrogen-containing bisphosphonates inhibit RANKL- and M-CSF-induced osteoclast formation through the inhibition of ERK1/2 and Akt activation. (2014)
  • Author(s): Tsubaki M, Komai M, Itoh T, Imano M, Sakamoto K, Shimaoka H, Takeda T, Ogawa N, Mashimo K, Fujiwara D, Mukai J, Sakaguchi K, Satou T, Nishida S.
  • Journal Title: J Biomed Sci. Volume: 21 Issue: 1 Pages: 10-10
  • DOI: 10.1186/1423-0127-21-10
  • Peer Reviewed
• [Journal Article] Cutaneous lymphangioma circumscriptum with marked blood presence: histopathologic evaluation of the endothelial cells (2014)
  • Author(s): Oiso N, Itoh T, Miyake M, Satou T, Kawada A
  • Journal Title: Eur J Dermatol Volume: 24 Issue: 1 Pages: 127-128
  • DOI: 10.1684/ejd.2013.2248
  • Peer Reviewed
• [Presentation] 運動による脳外傷後の脳機能改善効果の検討 (2017)
  • Author(s): 吉田原規、伊藤龍生、橋本重夫、土手健作、佐藤隆夫
  • Organizer: 第106回日本病理学会総会大会
  • Place of Presentation: 京王プラザホテル（東京都、新宿区）
  • Year and Date: 2017-04-27
• [Presentation] 妊娠期高血糖曝露差がラット胎仔神経幹細胞分化に及ぼす影響 (2016)
  • Author(s): 吉田大亮、藤原隆史、福田麻美、藪口友暉、小倉あづき、水口信行、蒲尚子、佐藤隆夫、伊藤龍生
  • Organizer: 第55回日本栄養・食糧学会・近畿支部大会
  • Place of Presentation: 帝塚山学院大学（大阪府、堺市）
  • Year and Date: 2016-10-22
• [Presentation] 母体高血糖がラット胎仔神経幹細胞分化に及ぼうす影響 (2016)
  • Author(s): 藤原隆史、吉田大亮、福田麻美、藪口友暉、金田雅大、森万優加、小倉あづき、足立夏実、水口信行、佐藤隆夫、伊藤龍生
  • Organizer: 第55回日本栄養・食糧学会・近畿支部大会
  • Place of Presentation: 帝塚山学院大学（大阪府、堺市）
  • Year and Date: 2016-10-22
• [Presentation] 運動による実験的脳外傷後に出現する神経幹細胞への影響 (2015)
  • Author(s): 伊藤龍生、橋本重夫、佐藤隆夫
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市熱田区）
  • Year and Date: 2015-04-29
• [Presentation] 外傷的脳損傷の損傷局所に及ぼす運動の影響について (2015)
  • Author(s): 佐藤隆夫、伊藤龍生、土手健作、橋本重夫
  • Organizer: 第104回日本病理学会総会
  • Place of Presentation: 名古屋国際会議場（愛知県名古屋市熱田区）
  • Year and Date: 2015-04-29