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The effects of exercise therapy on the recovery of memory function in internal capsule stroke model rats

Research Project

Project/Area Number 26350599
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Rehabilitation science/Welfare engineering
Research InstitutionKawasaki Medical School

Principal Investigator

HIMI Naoyuki  川崎医科大学, 医学部, 講師 (70412161)

Co-Investigator(Kenkyū-buntansha) 宮本 修  川崎医科大学, 医学部, 教授 (00253287)
岡部 直彦  川崎医科大学, 医学部, 助教 (30614276)
Co-Investigator(Renkei-kenkyūsha) TAKAHASHI Hisashi  川崎医療福祉大学, 医療技術学部, 講師 (30612981)
KOGA Tomoshige  川崎医療福祉大学, 医療技術学部, 教授 (50186649)
Research Collaborator SHIROMOTO Takashi  
LU Feng  
MARUYAMA Emi (NAKAMURA Emi)  
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords脳梗塞 / リハビリテーション / 内包
Outline of Final Research Achievements

The new internal capsule (IC) stroke model using the optic fiber has been reported by other group in 2014. Therefore we have switched from optic fiber method to microsphere (MS) injection model showing memory dysfunction and IC stroke model-like motor dysfunction. Rats were forced to run on a treadmill with mild strength for 7 days as the exercise (Ex group). At the 8th day after beginning the exercise, MS were injected. Non-exercise group (NE group) and sham operated groups were also examined as control groups. The Morris water maze test were performed at 8 days after onset stroke. The memory functions in the Ex group was significantly improved compared with the NE group. However, in the severer MS model (increased number of particles), exercise showed no significant motor functional recovery.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report

Research Products

(4 results)

All 2015 Other

All Presentation (1 results) (of which Int'l Joint Research: 1 results) Remarks (3 results)

  • [Presentation] The early elevation of hippocampal BDNF by exercise after cerebral microemboli reduces the apoptosis of neuron2015

    • Author(s)
      氷見 直之
    • Organizer
      第27回 国際脳循環代謝学会会議
    • Place of Presentation
      カナダ・バンクーバー
    • Year and Date
      2015-06-27
    • Related Report
      2015 Research-status Report
    • Int'l Joint Research
  • [Remarks] 川崎医科大学・生理学2教室ホームページ

    • URL

      http://www.kawasaki-m.ac.jp/physiology/

    • Related Report
      2016 Annual Research Report
  • [Remarks] 川崎医科大学・生理学2教室 研究

    • URL

      http://www.kawasaki-m.ac.jp/physiology/res.html

    • Related Report
      2015 Research-status Report
  • [Remarks] 川崎医科大学・生理学2教室

    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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