| Project/Area Number |
26350636
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Hamamatsu University School of Medicine (2015-2016)
Hamamatsu University (2014) |
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Principal Investigator |
Oboshi Yumi 浜松医科大学, 光尖端医学教育研究センター, 特任助教 (70613975)
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| Co-Investigator(Kenkyū-buntansha) |
尾内 康臣 浜松医科大学, 光尖端医学教育研究センター, 教授 (40436978)
菊知 充 金沢大学, 子どものこころの発達研究センター, 教授 (00377384)
河合 正好 常葉大学, 保健医療学部, 教授 (30283352)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
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| Keywords | リハビリテーション / 脳賦活 / 光イメージング / 認知機能 / NIRS / 前頭前野 / タスクセット / 作業記憶 |
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| Outline of Final Research Achievements |
To evaluate the cognitive decline at the early period in the cognitively healthy elderly, we modified the visual working memory task and measured cerebral blood flow responses during the task-set and task period using near-infrared spectroscopy (NIRS). We found that prefrontal activation was larger during the task execution than during the task-set period. However, with repetition of the task sessions, the activation during task-set period tended to be larger and the task-induced activation to be smaller in the frontal pole area. Furthermore, the activation during the task-set period was significantly correlated with the scores of several neuropsychological tests for prefrontal function. As a result, the temporal characteristics of prefrontal activation might reflect the cognitive function of the elderly people.
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