Does a treadmill running exercise contribute to preventing deterioration of bone mineral density and bone quality of the femur in KK-Ay mice, a type 2 diabetic animal model?

• Project/Area Number: 26350637
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Rehabilitation science/Welfare engineering
• Research Institution: Tokoha University (2015-2016); Hamamatsu University (2014)
• Principal Investigator: TAKAGI Satoshi 常葉大学, 保健医療学部, 教授 (70712305)
• Co-Investigator(Kenkyū-buntansha): 山下 剛範 鈴鹿医療科学大学, 保健衛生学部, 准教授 (10410937)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
• Keywords: 2型糖尿病 / トレッドミル走行 / 骨密度 / 骨質 / 骨代謝 / 糖・脂質代謝 / 大腿骨骨密度 / 糖尿病性骨減少症

Outline of Final Research Achievements

We examined the protective effect of treadmill running exercise on decreasing bone mineral density (BMD) and bone quality in diabetes mellitus using KK-Ay mice, an animal model of type 2 diabetes. It was clarified that running at slow speed for a long duration was more effective to the BMD of the femur than fast speed and short duration in type 2 diabetes, and that glycemic control, insulin sensitivity and fat mass were associated with the mechanism. In addition, it was suggested that a decrease in bone resorption action by exercise was also associated with that. However we could not find the change in microarchitecture of the femur. Further investigations will be necessary to establish the most appropriate exercise program to prevent deterioration of bone quality.

Research Products

• [Journal Article] 糖尿病患者の骨折リスクと運動療法 (2017)
  • Author(s): 高木 聖、山下剛範、三浦俊宏
  • Journal Title: DM Ensemble Volume: 5 Pages: 50-53
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 糖尿病関連骨粗鬆症に対するトレッドミル走行の有効性 －2型糖尿病モデル動物を用いての検証－ (2017)
  • Author(s): 高木 聖
  • Organizer: 第54回日本リハビリテーション医学会
  • Place of Presentation: 岡山
  • Year and Date: 2017-06-08
• [Presentation] 糖尿病の骨の異常 (2016)
  • Author(s): 高木 聖
  • Organizer: 第51回日本理学療法学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2016-05-27
  • Invited
• [Presentation] トレッドミル走行が糖尿病性骨減少症におよぼす影響－運動強度・時間とその関連因子についての検証 (2015)
  • Author(s): 高木 聖, 三浦俊宏, 山下剛範
  • Organizer: 第70回日本体力医学会大会
  • Place of Presentation: 和歌山
  • Year and Date: 2015-09-18
• [Presentation] 糖尿病性骨減少症に対するトレッドミル走行の有効性について－遺伝的2型糖尿病モデル動物を用いての検討－ (2015)
  • Author(s): 高木 聖
  • Organizer: 第52回日本リハビリテーション医学会学術集会
  • Place of Presentation: 新潟
  • Year and Date: 2015-05-28 – 2015-05-30