| Project/Area Number |
26350637
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Rehabilitation science/Welfare engineering
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| Research Institution | Tokoha University (2015-2016)
Hamamatsu University (2014) |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
山下 剛範 鈴鹿医療科学大学, 保健衛生学部, 准教授 (10410937)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | 2型糖尿病 / トレッドミル走行 / 骨密度 / 骨質 / 骨代謝 / 糖・脂質代謝 / 大腿骨骨密度 / 糖尿病性骨減少症 |
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| Outline of Final Research Achievements |
We examined the protective effect of treadmill running exercise on decreasing bone mineral density (BMD) and bone quality in diabetes mellitus using KK-Ay mice, an animal model of type 2 diabetes. It was clarified that running at slow speed for a long duration was more effective to the BMD of the femur than fast speed and short duration in type 2 diabetes, and that glycemic control, insulin sensitivity and fat mass were associated with the mechanism. In addition, it was suggested that a decrease in bone resorption action by exercise was also associated with that. However we could not find the change in microarchitecture of the femur. Further investigations will be necessary to establish the most appropriate exercise program to prevent deterioration of bone quality.
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