The effect of reward system on neurogenesis and exercise

• Project/Area Number: 26350697
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Developmental mechanisms and the body works
• Research Institution: Kyoto Prefectural University of Medicine
• Principal Investigator: INOKAWA HITOSHI 京都府立医科大学, 医学(系)研究科(研究院), 講師 (40285250)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ドーパミン / サーカディアン / 神経新生 / 概日リズム

Outline of Final Research Achievements

It is becoming clear that exercise not only maintains physical activity level but also suppresses chronic diseases and has the effect of promoting neurogenesis in the central nervous system. In addition, it is becoming clear that the function of dopamine in basal ganglia is important for normal movement. It is also considered that there is a diurnal variation in dopamine release. Therefore, we examined whether the dopamine system and circadian rhythm affect neurogenesis, the relationship of spontaneous motor behavior and neurogenesis, and the regulation by circadian rhythm of dopamine. We are analyzing the relationship between spontaneous momentum and neurogenesis using immunostaining. There was also a tendency for dopamine release to have a difference in day and night.

Research Products

• [Journal Article] Characteristics of fast-spiking neurons in the striatum of behaving monkeys. (2016)
  • Author(s): Yamada H, Inokawa H, Hori Y, Pan X, Matsuzaki R, Nakamura K, Samejima K, Shidara M, Kimura M, Sakagami M, Minamimoto T.
  • Journal Title: Neurosci Res. Volume: 105 Pages: 2-18
  • DOI: 10.1016/j.neures.2015.10.003
  • NAID: 120007135484
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of Multiple clock gene ablations on the circadian period-length and temperature compensation in mammalian cells. (2016)
  • Author(s): Tsuchiya Y., Umemura Y., Minami Y., Koike N., Hosokawa T., Hara M., Ito H., Inokawa H. & Yagita K.
  • Journal Title: Journal of Biological Rhythms Volume: 31 Issue: 1 Pages: 48-56
  • DOI: 10.1177/0748730415613888
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur. (2015)
  • Author(s): Okubo N, Fujiwara H, Minami Y, Kunimoto T, Hosokawa T, Umemura Y, Inokawa H, Asada M, Oda R, Kubo T, Yagita K.
  • Journal Title: Acta Orthopedica Volume: 13 Issue: 5 Pages: 1-5
  • DOI: 10.3109/17453674.2015.1029393
  • Peer Reviewed / Open Access / Acknowledgement Compliant