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The effect of reward system on neurogenesis and exercise

Research Project

Project/Area Number 26350697
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Developmental mechanisms and the body works
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

INOKAWA HITOSHI  京都府立医科大学, 医学(系)研究科(研究院), 講師 (40285250)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsドーパミン / サーカディアン / 神経新生 / 概日リズム
Outline of Final Research Achievements

It is becoming clear that exercise not only maintains physical activity level but also suppresses chronic diseases and has the effect of promoting neurogenesis in the central nervous system. In addition, it is becoming clear that the function of dopamine in basal ganglia is important for normal movement. It is also considered that there is a diurnal variation in dopamine release. Therefore, we examined whether the dopamine system and circadian rhythm affect neurogenesis, the relationship of spontaneous motor behavior and neurogenesis, and the regulation by circadian rhythm of dopamine. We are analyzing the relationship between spontaneous momentum and neurogenesis using immunostaining. There was also a tendency for dopamine release to have a difference in day and night.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (3 results)

All 2016 2015

All Journal Article (3 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results)

  • [Journal Article] Characteristics of fast-spiking neurons in the striatum of behaving monkeys.2016

    • Author(s)
      Yamada H, Inokawa H, Hori Y, Pan X, Matsuzaki R, Nakamura K, Samejima K, Shidara M, Kimura M, Sakagami M, Minamimoto T.
    • Journal Title

      Neurosci Res.

      Volume: 105 Pages: 2-18

    • DOI

      10.1016/j.neures.2015.10.003

    • NAID

      120007135484

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effect of Multiple clock gene ablations on the circadian period-length and temperature compensation in mammalian cells.2016

    • Author(s)
      Tsuchiya Y., Umemura Y., Minami Y., Koike N., Hosokawa T., Hara M., Ito H., Inokawa H. & Yagita K.
    • Journal Title

      Journal of Biological Rhythms

      Volume: 31 Issue: 1 Pages: 48-56

    • DOI

      10.1177/0748730415613888

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Parathyroid hormone resets the cartilage circadian clock of the organ-cultured murine femur.2015

    • Author(s)
      Okubo N, Fujiwara H, Minami Y, Kunimoto T, Hosokawa T, Umemura Y, Inokawa H, Asada M, Oda R, Kubo T, Yagita K.
    • Journal Title

      Acta Orthopedica

      Volume: 13 Issue: 5 Pages: 1-5

    • DOI

      10.3109/17453674.2015.1029393

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant

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Published: 2014-04-04   Modified: 2018-03-22  

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