Effects of short-duration intermittent hypoxia on endurance exercise capacity in mice

• Project/Area Number: 26350810
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Sports science
• Research Institution: Hokkaido University of Education
• Principal Investigator: SUZUKI JUNICHI 北海道教育大学, 教育学部, 教授 (80261379)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 低酸素曝露 / トレーニング / 脂肪代謝 / 持久的運動能力 / 反復低酸素暴露 / 脂肪酸代謝 / 毛細血管 / 血管内皮細胞増殖因子 / PGC-1a

Outline of Final Research Achievements

This study was designed to (1) investigate the effects of acute short-duration intermittent hypoxia on muscle mRNA and microRNA expression levels; (2) clarify the mechanisms by which short-duration intermittent hypoxia improves endurance capacity; (3) investigate the effects of short-duration intermittent hypoxia on endurance capacity in well-trained individuals. The present results suggest that exercise training under normoxic atmosphere with short-duration intermittent hypoxia represents a useful strategy for improving endurance performance in highly trained individuals.

Research Products

• [Journal Article] Endurance performance in well-trained mice is enhanced by short-duration intermittent hypoxia via improved muscle fatty acid metabolism (2017)
  • Author(s): Suzuki J
  • Journal Title: Experimental Physiology Volume: 印刷中 Issue: 6 Pages: 738-738
  • DOI: 10.1113/ep086254
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Short-duration intermittent hypoxia enhances endurance capacity by improving muscle fatty acid metabolism in mice (2016)
  • Author(s): Suzuki J
  • Journal Title: Physiological Reports Volume: 4 Issue: 7 Pages: e12744-e12744
  • DOI: 10.14814/phy2.12744
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Muscle microvascular adaptation and angiogenic gene induction in response to exercise training are attenuated in middle-aged rats (2015)
  • Author(s): Junichi SUZUKI
  • Journal Title: Comparative Exercise Physiology Volume: 11 Issue: 1 Pages: 23-33
  • DOI: 10.3920/cep150007
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Exercise-induced capillary growth in skeletal muscle (2015)
  • Author(s): Junichi SUZUKI
  • Journal Title: Advances in Exercise Physiology Volume: 21 Pages: 1-6
  • NAID: 110009957646
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 短時間の反復低酸素暴露が長期間トレーニングを積んだマウスの全身持久力向上に及ぼす影響 (2016)
  • Author(s): 鈴木淳一
  • Organizer: 第24回日本運動生理学会
  • Place of Presentation: 熊本大学（熊本県・熊本市）
  • Year and Date: 2016-07-25
• [Presentation] 短時間の反復低酸素暴露がトレーニングによる全身持久力向上に及ぼす影響 (2015)
  • Author(s): 鈴木淳一
  • Organizer: 第23回 日本運動生理学会大会
  • Place of Presentation: 日本体育大学（東京）
  • Year and Date: 2015-07-25
• [Presentation] 中年期ラットにおける持久的運動がVEGFとmicroRNA発現におよぼす影響 (2014)
  • Author(s): 鈴木淳一
  • Organizer: 第22回日本運動生理学会大会
  • Place of Presentation: 川崎医療福祉大学
  • Year and Date: 2014-07-20
• [Remarks] 北海道教育大学 研究者総覧
  • URL: http://kensoran.hokkyodai.ac.jp/huehp/KgApp?kyoinId=ymikggggggo&keyword=