Elucidation of the functional role of endoplasmic reticulum stress and autophagy for sarcopenia
| Project/Area Number |
26350815
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Tokyo Institute of Technology (2015-2016)
Toyohashi University of Technology (2014) |
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Principal Investigator |
Sakuma Kunihiro 東京工業大学, リベラルアーツ研究教育院, 教授 (60291176)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 加齢 / 骨格筋 / 小胞体ストレス / サルコペニア / オートファジー / 筋萎縮 / レスベラトロール / 除神経 / 低タンパク質 / プロテインキナーゼC |
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| Outline of Final Research Achievements |
Using senescent mice (24-month-old), I investigated the adaptive changes in endoplasmic reticulum stress-linked molecules in skeletal muscle. Although we observed the marked increase in the amount of IRE-1a and PKCtheta protein in cytosol of aged muscle fibers, these expressing position are not equal at those position of autophagy-linked molecules. Long-term low-protein-diet did not attenuate sarcopenic symptom. Supplementation with resveratrol, which decrease endoplasmic reticulum stress, attenuated muscle atrophy after denervation in mice.
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Report
(4 results)
Research Products
(31 results)
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[Presentation] サルコペニア発症の分子機構2015
Author(s)
佐久間邦弘
Organizer
第2回日本サルコペニアフレイル研究会 研究発表会
Place of Presentation
東京大学伊藤国際学術研究センター
Year and Date
2015-10-04
Related Report
Invited
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