Some aspects of surtuin in exercise-associated adaptation of skeletal muscle
Project/Area Number |
26350818
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Sports science
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Research Institution | Hirosaki Gakuin University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
後藤 勝正 (山下勝正 / 後藤 勝正(山下勝正)) 豊橋創造大学, 保健医療学部, 教授 (70239961)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | 骨格筋 / 長寿遺伝子 / 萎縮 / 再成長 / ストレス応答 / AMPK / 筋再生 |
Outline of Final Research Achievements |
It is still unclear that physical exercise is associated with a longer life span. Physical-exercise-associated intracellular and extracellular stimuli are diverse. Since physiological and anatomical systems of human body have a potential to adapt to these various stimuli, a sensory system in individual cells remains unknown. The purpose of this study was to investigate whether a longevity gene, so-called surtuin (SIRT), plays a role in skeletal muscle plasticity in response to exercise-associated stimuli using experimental animals and cell culture systems. Evidences of this study suggest that SIRT itself may not have a direct role in the adaptation of skeletal muscle in response to exercise stimuli.
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Report
(4 results)
Research Products
(54 results)
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[Journal Article] Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading2016
Author(s)
Yokoyama S, Ohno Y, Egawa T, Yasuhara K, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Okita M, Origuchi T, Goto K
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Journal Title
Acta Physiol (Oxf)
Volume: 217
Issue: 4
Pages: 325-337
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Suppression of myostatin stimulates regenerative potential of injured antigravitational soleus muscle in mice under unloading condition2016
Author(s)
Ohno, Y., Matsuba, Y., Hashimoto, N., Sugiura, T., Ohira, Y., Yoshioka, T., Goto, K.
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Journal Title
International Journal of Medical Sciences
Volume: 13
Issue: 9
Pages: 680-685
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Involvement of AMPK in regulating slow-twitch muscle atrophy during hindlimb unloading in mice.2015
Author(s)
Egawa T, Goto A, Ohno Y, Yokoyama S, Ikuta A, Suzuki M, Sugiura T, Ohira Y, Yoshioka T, Hayashi T, Goto K.
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Journal Title
Am J Physiol Endocrinol Metab.
Volume: 309
Issue: 7
Pages: E651-E662
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Nuclear and cytoplasmic muscleblind-like 1 in mouse skeletal muscle in response to aging and unloading with or without reloading2016
Author(s)
Nakamura, A., Ito, R., Ikegaya, N., Higa, M., Yokoyama, S., Ohno, Y., Sugiura, T., Ohira, Y., Yoshioka, T., Baehr, L.M., Bodine, S.C., Goto, K.
Organizer
APS (American Physiological Society) Intersociety Meeting: The Integrative Biology of Exercise Ⅶ
Place of Presentation
Hyatt Reagency Phenix, Phenix, AZ, USA
Year and Date
2016-11-02
Related Report
Int'l Joint Research
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[Presentation] A role of heat shock transcription factor 1 in the regulation of slow type myosin heavy chain expression in mouse soleus muscle2016
Author(s)
Goto, K., Yokoyama, S., Yasuhara, K., Nakai, A., Sugiura, T., Yoshioka, T.
Organizer
FASEB Science Research Conferences “Skeletal Muscle Satellite Cells and Regeneration”
Place of Presentation
Keystone Resort Conference Center, Keystone, CO, USA
Year and Date
2016-07-24
Related Report
Int'l Joint Research
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[Presentation] A physiological role of skeletal muscle-derived adiponectin in C2C12 differentiation2016
Author(s)
Goto, K., Ito, R., Yokoyama, S., Sugiura, T., Miyata, H., Ohira, Y., Yoshioka, T.
Organizer
Molecular Mechanisms Modulating Skeletal Muscle Development and Homeostasis in Health and Disease
Place of Presentation
Asilomar Conference Grounds, Pacific Grove, CA, USA
Year and Date
2016-06-06
Related Report
Int'l Joint Research
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[Presentation] Typical responses of nuclear shape and distribution in skeletal muscle fibers in senescence-accelerated mice2015
Author(s)
Goto, K., Yokoyama, S., Suzuki, S., Ikuta, A., Ito, R., Ikegaya, N., Onimura, T., Higa, M., Nakamura, A., Egawa, T., Ohno, Y., Sugiura, T., Ohira, Y., Yoshioka, T.
Organizer
International Conference on Biochemistry of Exercise (IBEC 2015)
Place of Presentation
Sao Paulo (Brazil)
Year and Date
2015-09-07
Related Report
Int'l Joint Research
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[Presentation] Involvement of AMPK on hindlimb unloading-induced adaptation of muscle mass in mice2015
Author(s)
Tatsuro Egawa, Ayumi Goto, Yoshitaka Ohno, Shingo Yokoyama, Miho Suzuki-Takuwa, Akihiro Ikuta, Tatsuya Hayashi, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka, Katsumasa Goto
Organizer
The 11th World Congress of of International Society for Adaptive Medicine (ISAM 2015)
Place of Presentation
米子コンベンションセンター(鳥取県米子市)
Year and Date
2015-05-27
Related Report
Int'l Joint Research
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[Presentation] Responses of circulating microRNAs to unloading-associated atrophy and reloading-induced regrowth of mouse hindlimb skeletal muscle2014
Author(s)
Miho Suzuki, Tatsuro Egawa, Akihiro Ikuta, Ayumi Goto, Shingo Yokoyama, Yoshitaka Ohno, Takao Sugiura, Yoshinobu Ohira, Toshitada Yoshioka, Katsumasa Goto
Organizer
Brisbane 2014 Australian Physiological Society (AuPS) Meeting
Place of Presentation
The University of Queensland, Brisbane(Australia)
Year and Date
2014-11-30 – 2014-12-03
Related Report
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[Presentation] Skeletal muscle function and serum thiobarbituric acid reactive substances level are improved by the combination treatment of catechin-ingestion with heat stress in healthy elderly women2014
Author(s)
Toshitada Yoshioka, HIdeshi Oda, Noriyasu Ota, Atsuya Watanabe, Hidefumi Kitazawa, Michihiko Igaki, Atsushi Suzuki, Akira Shimotoyodome, Tadashi Hase, Takao Sugiura, Katsumasa Goto
Organizer
43rd European Muscle Conference 2014 (EMC 2014)
Place of Presentation
Salzburg(Austria)
Year and Date
2014-09-10 – 2014-09-14
Related Report
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