| Project/Area Number |
26350820
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Sports science
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| Research Institution | Juntendo University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
内藤 久士 順天堂大学, スポーツ健康科学研究科, 教授 (70188861)
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| Research Collaborator |
TSUZUKI Takamasa
POWERS Scott K
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
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| Keywords | 機械的人工換気 / 間欠的自発呼吸 / 横隔膜 / 筋萎縮 / 回復期 / ラット / 回復メカニズム |
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| Outline of Final Research Achievements |
We focused on development of improved rodent model of mechanical ventilation (MV) and clarify the mechanisms of the recovery from ventilator-induced diaphragm dysfunction (VIDD). However, new improved model was not completely developed since there are lot of problems that should be resolved.
Thus, we changed our plan and focused on the effect of intermittent spontaneous breathing which can apply during MV without any preparation before MV. Limited data exist regarding the impact of intermittent spontaneous breathing during MV on protection against VIDD. Adult male rats were randomly assigned to one of three groups: control (CON) with no MV; controlled MV (CMV) for 12 hours; and intermittent spontaneous breathing during MV (IMV). Our findings reveal that as little as 1-min/hour of spontaneous breathing during MV is protective against VIDD, in part, by prevention of MV-induced activation ofcaspase-3 and STAT3 in the diaphragm.
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