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Effcts of voluntary exercise on neurotransmitters in the preoptic area and anterior hypothalamus and thermoregulation in rats

Research Project

Project/Area Number 26350822
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Sports science
Research InstitutionRikkyo University

Principal Investigator

ISHIWATA TAKAYUKI  立教大学, コミュニティ福祉学部, 准教授 (40435235)

Co-Investigator(Renkei-kenkyūsha) HASEGAWA Hiroshi  広島大学, 総合科学研究科, 教授 (70314713)
YANAGITA Shinya  東京理科大学, 理工学部, 助教 (80461755)
Research Collaborator SUZUKI Kota  
MATSUMURA Takeru  
NAKAGAWA Hikaru  
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywords脳内神経伝達物質 / 自発運動 / 体温調節 / 深部体温 / 心拍数 / 活動量 / 神経伝達物質
Outline of Final Research Achievements

The preoptic area and anterior hypothalamus (PO/AH) is considered to be the primary locus for thermoregulatory system. In addition, serotonin (5-HT), dopamine (DA) and norepinephrine (NE) are very important monoaminergic neurotransmitter and its system has been involved in the regulation of thermoregulation. In this study, we investigated in the effects of voluntary exercise on brain monoaminergic neurotransmitters and thermoregulation in rats. Results showed that the heart rate in the voluntary exercise group were lower level compared with control group. Furthermore, core body temperature in the exercise group also showed clear circadian rhythm during the day compared with control group. The levels of NE and DA in the PO/AH in voluntary exercise group were higher than control group significantly. These results indicate that voluntary exercise may affect on the health and condition in the brain neurotransmitters.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (12 results)

All 2017 2016 Other

All Int'l Joint Research (2 results) Journal Article (4 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 4 results,  Acknowledgement Compliant: 2 results) Presentation (2 results) (of which Invited: 1 results) Remarks (3 results) Funded Workshop (1 results)

  • [Int'l Joint Research] University of Colorado Denver(米国)

    • Related Report
      2017 Annual Research Report
  • [Int'l Joint Research] University of Colorado Denver(米国)

    • Related Report
      2016 Research-status Report
  • [Journal Article] Exercise increases mTOR signaling in brain regions involved in cognition and emotional behavior2017

    • Author(s)
      Lloyd Brian A.、Hake Holly S.、Ishiwata Takayuki、Farmer Caroline E.、Loetz Esteban C.、Fleshner Monika、Bland Sondra T.、Greenwood Benjamin N.
    • Journal Title

      Behavioural Brain Research

      Volume: 323 Pages: 56-67

    • DOI

      10.1016/j.bbr.2017.01.033

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] The Prevalence and Clinicopathological Characteristics of High-Grade Pancreatic Intraepithelial Neoplasia: Autopsy Study Evaluating the Entire Pancreatic Parenchyma.2017

    • Author(s)
      1.Matsuda Y, Furukawa T, Yachida S, Nishimura M, Seki A, Nonaka K, Aida J, Takubo K, Ishiwata T, Kimura W, Arai T, Mino-Kenudson M.
    • Journal Title

      Pancreas

      Volume: 46 Issue: 5 Pages: 658-664

    • DOI

      10.1097/mpa.0000000000000786

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Possible mechanisms of hypothermia after inhibition of the median or dorsal raphe nucleus of freely moving rats2016

    • Author(s)
      Takayuki Ishiwata, Arisa Oshimoto, Takehito Saito, Yasunori Kotani, Shigeki Nomoto, Yasutsugu Aihara, Hiroshi Hasegawa, Benjamin N. Greenwood
    • Journal Title

      NeuroReport

      Volume: 27 Pages: 1287-1292

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Changes of brain monoamine levels and physiological indexes during heat acclimation in rats2016

    • Author(s)
      Hikaru Nakagawa, Takeru Matsumura, Kota Suzuki, Chisa Ninomiya, Takayuki Ishiwata
    • Journal Title

      Journal of Thermal Biology

      Volume: 58 Pages: 15-22

    • DOI

      10.1016/j.jtherbio.2016.03.010

    • Related Report
      2016 Research-status Report
    • Peer Reviewed
  • [Presentation] ラットの体温調節機構における脳内セロトニンの関与~マイクロダイアリシス,テレメトリー,ホモジネート,行動実験によるアプローチ~2017

    • Author(s)
      石渡貴之
    • Organizer
      第31回運動と体温の研究会
    • Related Report
      2017 Annual Research Report
    • Invited
  • [Presentation] 環境ストレスに対する生理指標,脳内神経伝達物質,情動行動の連関2017

    • Author(s)
      石渡貴之
    • Organizer
      第25回日本運動生理学会大会(シンポジウムⅣ:「脳-身体-環境の連関について、行動神経科学的アプローチからの知見を運動生理学に生かす」)
    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://www2.rikkyo.ac.jp/web/ishiwata/Ishiwata_Lab/Welcome.html

    • Related Report
      2017 Annual Research Report
  • [Remarks]

    • URL

      http://univdb.rikkyo.ac.jp/view?l=ja&u=1179&n=%E7%9F%B3%E6%B8%A1&sm=name&sl=ja&sp=1

    • Related Report
      2017 Annual Research Report
  • [Remarks] 立教大学研究者情報

    • URL

      http://univdb.rikkyo.ac.jp/view?l=ja&u=1179&n=%E7%9F%B3%E6%B8%A1&sm=name&sl=ja&sp=1

    • Related Report
      2016 Research-status Report
  • [Funded Workshop] 日米若手研究者による運動行動神経科学研究会 in Denver2016

    • Place of Presentation
      University of Colorado Denver, コロラド州デンバー,アメリカ
    • Year and Date
      2016-12-06
    • Related Report
      2016 Research-status Report

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Published: 2014-04-04   Modified: 2022-06-07  

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