| Project/Area Number |
26350853
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Kyoto Tachibana University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
藤野 英己 神戸大学, 保健学研究科, 教授 (20278998)
村上 慎一郎 姫路獨協大学, 医療保健学部, 教授 (30454763)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | 加齢 / 末梢神経 / 有髄線維退行 / 毛細血管退行 / 低強度運動介入 / 有髄線維構造改善 / 毛細血管再構築 / 長期的運動介入 / 有髄線維構造維持 |
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| Outline of Final Research Achievements |
We investigated the age-related regression of the tibial nerve and capillary, and the effects of the aerobic exercise to aged tibial nerve and capillary. The myelinated fibers and capillaries in the tibial nerves of elderly group significantly atrophied and deceased in comparison with those of young rats. The tissue and serum BDNF (promoting factor of repair and survival of myelinated fiber) of aerobic exercise (Ex) group (2 weeks) significantly increased and decreased in comparison with those of control (Con) group, respectively. In contrast, the tissue and serum VEGF (promoting factor of angiogenesis) of Ex group significantly decreased and increased in comparison with those of Con group, respectively. According the above results, it has been revealed that both the peripheral nerve and capillary are able to survive and regenerate with complementary relation.
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