Investigation of improvement of insulin resistance by probiotics

Research Project

Project/Area Number	26350871
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Multi-year Fund
Section	一般
Research Field	Applied health science
Research Institution	Juntendo University
Principal Investigator	Kanazawa Akio 順天堂大学, 医学部, 准教授 (30407259)
Project Period (FY)	2014-04-01 – 2017-03-31
Project Status	Completed (Fiscal Year 2016)
Budget Amount *help	¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000) Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000) Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000) Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords	腸内フローラ / プロバイオティクス / インスリン抵抗性
Outline of Final Research Achievements	Seventy Japanese patients with type 2 diabetes were randomised to two groups: the probiotic group drank Lactobacillus casei strain Shirota-fermented milk for 16 weeks, while the control group ingested no probiotics. At the end of the study, the fecal counts of the Lactobacillus in the probiotic group were significantly higher than in the control group. Intriguingly, the total count of blood bacteria was significantly lower in the probiotic group [2.0(1.0-3.0)/6.0(3.0-12.0) cells /ml, P<0.05]. Our results showed that probiotic administration reduced bacterial translocation in Japanese patients with type 2 diabetes mellitus.