Approach from physiological functions in mechanisms of stress, quality and quantity of sleep and sense of well-being.

• Project/Area Number: 26350876
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Prefectural University of Hiroshima
• Principal Investigator: Iida Tadayuki 県立広島大学, 保健福祉学部(三原キャンパス), 教授 (50290549)
• Co-Investigator(Kenkyū-buntansha): 八谷 寛 藤田保健衛生大学, 医学部, 教授 (30324437) ; 伊藤 康宏 藤田保健衛生大学, 保健学研究科, 教授 (40176368) ; 井上 顕 高知大学, 教育研究部医療学系臨床医学部門, 教授 (40469036) ; 巽 あさみ 浜松医科大学, 医学部, 教授 (90298513)
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
• Keywords: 睡眠 / 自律神経活動 / ストレス / u-8-OHdG / u-5-HT / SDS / STAI / ストレス関連バイオマーカー / 心理的ストレス / 自律神経 / 感情

Outline of Final Research Achievements

The percentage of people with work- and life-related anxiety, worry, and stress is increasing every year, and it is said to exceed 60%. The relationship between psychological stress and oxidative stress has become a focus of interest, and the mechanism by which psychological stress increases reactive oxygen species (ROS) is slowly being elucidated. This study focused on [Association between the Profile of Mood States and Autonomic Nervous System Activity during Sleep] and [Effects of psychological stress on the urine 8-hydroxy-deoxyguanosine levels in young female students, taking into account the menstrual cycle]. Mood changes showed an association with sympathetic and parasympathetic nervous system activities during sleep, suggesting the possibility of these activities influencing moods.This study also showed that U8-OHdG levels increased with the psychological stress of a national license examination.

Research Products

• [Journal Article] Effects of Psychological Stress from a National License Examination on the Urine 8-Hydroxy-Deoxyguanosine Levels in Young Female Students, Taking into Account the Menstrual Cycle (2018)
  • Author(s): Iida Tadayuki、Ito Yasuhiro、Ishikawa Hiroaki、Kanazashi Miho、Teradaira Ryoji、Tatsumi Asami、Ezoe Satoko
  • Journal Title: Open Journal of Preventive Medicine Volume: 08 Issue: 02 Pages: 21-31
  • DOI: 10.4236/ojpm.2018.82003
  • Peer Reviewed / Open Access
• [Journal Article] Association between the Profile of Mood States and Autonomic Nervous System Activity during Sleep in Female students (2018)
  • Author(s): Iida T, Kunishige M, Ito Y, Tatsumi A, Nagaoka K, Ezoe S, Harada T.
  • Journal Title: International Medical Journal Volume: 25 Pages: 66-66
  • Peer Reviewed
• [Journal Article] Aged-dependent contributions of neck circumference to indices of obesity among female college students aged 18 to 20 years. (2017)
  • Author(s): Nitta Y, Miki Y, Aoi S, Ikeda H, Iida T, Chikamura C, Tamura N, Nitta K, Miyaguchi H, Harada T, Ishizaki F
  • Journal Title: Hiroshima J Med Sci Volume: 66 Pages: 109-115
  • NAID: 130007661313
  • Peer Reviewed
• [Journal Article] Relationship between Peripheral Vascular Metabolic Change and Handgrip Exercise (2017)
  • Author(s): Harada T , Yamamoto S, Fujita T, Ishizaki F, Nitta Y, Ito S, Niyada K, Aoi S, Ikeda H, Hiroto H, Nakamura S, Takigawa A, Yoshida A, Iida T, Nitta K.
  • Journal Title: International Medical Journal Volume: 24 Pages: 321-323
  • Peer Reviewed
• [Journal Article] Influence of interaction among the elderly through amusement on their physiological function: One-month introduction at a day care service center for the elderly (2017)
  • Author(s): Kawabata N, Miyaguchi H, Kunishige M, Ishizuki C,Ito Y, Harada T, Iida T
  • Journal Title: Asian J Occup Ther Volume: 13 Pages: 23-30
  • NAID: 130006887038
  • Peer Reviewed
• [Journal Article] Changes in Biomarkers of Psychological Stress and Bone Resorption Markers in Young Females With and Without Depressive Symptoms during Different Menstrual Phases (2017)
  • Author(s): Iida T, Inoue K, Ito Y, Ishikawa H, Kagiono M, Chikamura C, Nagaoka K, Harada T, Teradaira R
  • Journal Title: International Medical Journal Volume: 24 Pages: 34-38
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 感覚-運動機能研究のための実験システム開発環境の構築と医工連携 (2016)
  • Author(s): 福田浩士，國重雅史，飯田忠行，宮口英樹，原田俊英
  • Journal Title: 日本神経回路学会誌 Volume: 23 Pages: 153-161
  • NAID: 130005308111
• [Journal Article] Relationship between the Characteristics of Lumbago of Parkinson's Disease and Efficacy of Neurotropin in Aged Patient (2016)
  • Author(s): Harada T, Ishizaki F, Nitta Y, Aoi S, Ikeda H, Iida T, Chikamura C, Nitta K.
  • Journal Title: International Medical Journal Volume: 23 Pages: 715-717
  • Peer Reviewed
• [Journal Article] Influences of High-Resolution Music Box Sounds on the Peripheral Vascular System. (2016)
  • Author(s): Harada T, Moriwaki Y, Ito S, Ishizaki F, Ymamoto R, Niyada K, Miyazaki H, Nitta Y, Aoi S, Ikeda H, Iida T, Nitta K.
  • Journal Title: International Medical Journal Volume: 23 Pages: 709-711
  • Peer Reviewed
• [Journal Article] The Need for Prompt Measures to Prevent People Age 70 or Over and Juveniles and Adolescents from Going Missing: the Importance of Devising Specific Measures to Deal with Behavior Caused by Dementia, Other Illnesses, or Family Problems. (2016)
  • Author(s): Inoue K, Fujita Y, Takeshita H, Yamamura Y, Fujita Y, Moriwaki S, Iida T, Sampei M, Ezoe S, Miyaoka T, Horiguchi J, Okazaki Y, Fukunaga T, Takeichi N, Hoshi M, Noso Y.
  • Journal Title: International Medical Journal Volume: 23 Pages: 641-643
  • Peer Reviewed
• [Journal Article] 若年者における睡眠と気分との関連 -抑うつ、不安、気分プロフィールを用いて- (2016)
  • Author(s): 飯田 忠行、 國重 雅史、 横川 奈央、 伊藤 康宏、 長岡 芳、 原田 俊英.
  • Journal Title: Bio Clinica Volume: 31 Pages: 62-65
• [Journal Article] Development of Japanese version of Smartphone Dependence Scale. (2016)
  • Author(s): Ezoe S, Iida T, Inoue K, Toda M.
  • Journal Title: Open Journal of Preventive Medicine, Volume: 6 Pages: 179-185
  • NAID: 120006841817
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Effective and specific approaches to measures to prevent suicide that should be enhanced in light of the latest transitions in Japan (2015)
  • Author(s): Inoue K, Miyaoka T, Takeshita H, Iida T, Wakatsuki T, Fujita Y, Hashioka S, Wake R, Tanaka I, Ezoe S Fujita Y, Fukunaga T, Okazaki Y, Horiguchi J
  • Journal Title: Journal of St. Marianna Medical Institute Volume: 15 Pages: 44-48
  • NAID: 40020526083
  • Peer Reviewed
• [Journal Article] Correlation of life problems with suicide rate: A discussion based on an epidemiological investigation (2015)
  • Author(s): Inoue K, Fukunaga T, Masaki M, Iida T, Wakatsuki T, Miyaoka T, Hashioka S, Wake R, Tanaka I, Fujita Y, Takeshita H, Fujita Y, Horiguchi J, Okazaki Y
  • Journal Title: Journal of St. Marianna Medical Institute Volume: 15 Pages: 40-43
  • Peer Reviewed
• [Journal Article] Comparison of urinary levels of 8-hydroxy-2'-deoxyguanosine between young females with and without depressive symptoms during different menstrual phases. (2015)
  • Author(s): Iida T, Inoue K, Ito Y, Ishikawa H, Kagiono M, Teradaira R, Chikamura C, Harada T, Ezoe S, Yatsuya H.
  • Journal Title: Acta Med Okayama Volume: 69 Pages: 45-50
  • NAID: 120005549927
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] 酸化ストレスマーカーと心理的ストレスの関連 (2015)
  • Author(s): 飯田忠行，伊藤康宏，原田俊英
  • Journal Title: 臨床化学 Volume: 44 Pages: 207-213
• [Journal Article] Comparison of Urinary Levels of 8-Hydroxy-2’-deoxyguanosine between Young Females with and without Depressive Symptoms during Different Menstrual Phases. (2015)
  • Author(s): Iida T, Inoue K, Ito Y, Ishikawa H, Kagiono M, Teradaira R, Chikamura C, Harada T, Ezoe S, Yatsuya H.
  • Journal Title: Acta Med. Okayama. Volume: 69 Pages: 45-50
  • NAID: 120005549927
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Neck Circumference has Possibility as a Predictor for Metabolic Syndrome in Postmenopausal Women. (2014)
  • Author(s): Aoi S, Miyake T, Harada T, Ishizaki F, Ikeda H, Nitta Y, Iida T, Chikamura C, Tamura N, Nitta k, Miyaguchi H.
  • Journal Title: Hiroshima Journal of Medical Sciences. Volume: 63 Pages: 27-32
  • NAID: 120005601180
  • Peer Reviewed
• [Journal Article] Thermographics Study on the Preservability of Heat Effects of Footbath with Salt. (2014)
  • Author(s): Harada T, Iwakawa Y, Ikeda H, Ishizaki F, Aoi S, Nitta Y, Yoshida A, Tamura N, Iida T, Shiokawa M, Nitta K.
  • Journal Title: Hiroshima Journal of Medical Sciences. Volume: 63 Pages: 1-5
  • NAID: 120005601176
  • Peer Reviewed
• [Journal Article] Relationship between an amount of Key Tasks and Job Satisfaction among Caregivers and Nurses in Elderly Care Facilities. (2014)
  • Author(s): Hiruta s, Shimaoka M, Tatsumi A, Ono Y, Iida T, Hori F.
  • Journal Title: Annals of Occupational and Environmental Medicine. Volume: 26 Pages: 24-24
  • Peer Reviewed / Open Access
• [Presentation] Influence of interaction among the elderly through amusement on their salivary amylase and autonomic nervous system activity : One-month introduction at a day care service center for the elderly (2017)
  • Author(s): Kawabata N, Miyaguchi H, Kunishige M, Ishizuki C,Ito Y, Harada T, Iida T
  • Organizer: International Society for Autonomic Neuroscience 2017,
  • Int'l Joint Research
• [Presentation] TBL評価と性格特性との関連 (2017)
  • Author(s): 飯田忠行， 三木洋一郎， 北川周子， 江崎 誠治， 細川 淳嗣， 川原田 淳
  • Organizer: 第46回日本医学教育学会
• [Presentation] Musculoskeletal Model Individualization for Analyzing Pelvic Floor Muscles Activity (2017)
  • Author(s): Wakaiki T, Tanaka T, Shimatani K, Iida T, Tsuchiya Y
  • Organizer: 5th INTERNATIONAL DIGITAL MUMAN MODELING SYMPOSIUM,
  • Int'l Joint Research
• [Presentation] ウォーキングの介入による体力・運動能力，生活習慣病指標，骨密度に及ぼす影響－ウォーキングとノルディックウォーキングの比較－ (2016)
  • Author(s): 高橋 栞，長谷川 正哉，塩川 満久，田中 聡，高宮 尚美，飯田 忠行
  • Organizer: 第51回日本理学療法学術大会
  • Place of Presentation: 札幌
  • Year and Date: 2016-05-27
• [Presentation] アミューズメントを介した高齢者の交流における自律神経機能・睡眠への影響－デイサービスにおける１ヶ月間の導入事例からの検討－ (2016)
  • Author(s): 川畑 なみ, 宮口 英樹, 國重 雅史, 石附 智奈美, 伊藤 康宏, 原田 俊英, 石崎 文子, 飯田 忠行.
  • Organizer: 日本老年医学会 中国地方会
  • Place of Presentation: 岡山
• [Presentation] 女子大学生の抑うつ、不安、u-8-OHdGおよびu-5-HTに 及ぼす国家試験の影響－月経周期要因を考慮して－ (2015)
  • Author(s): 飯田忠行，井上顕，江副智子
  • Organizer: 第31回日本ストレス学会学術集会
  • Place of Presentation: 杏林大学
  • Year and Date: 2015-11-07
• [Presentation] 中高年女性におけるメタボリックシンドローム関連指標がbaPWVに及ぼす影響－3年間の縦断調査から－ (2015)
  • Author(s): 飯田 忠行, 青井 聡美, 石崎 文子, 池田 ひろみ, 田村 典子, 近村 千穂, 塩川 満久, 原田 俊英
  • Organizer: 第57回日本老年医学会学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2015-06-13 – 2015-06-14
• [Presentation] 中高年女性におけるメタボリックシンドローム関連指標がbaPWVに及ぼす影響－3年間の縦断調査から－ (2015)
  • Author(s): 飯田 忠行, 青井 聡美, 石崎 文子, 池田 ひろみ, 田村 典子, 近村 千穂, 塩川 満久, 原田 俊英
  • Organizer: 第57回日本老年医学会学術集会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2015-06-12
• [Presentation] Moodleを用いたTBLシステムの構築-学生の理解度を含めて- (2015)
  • Author(s): 飯田忠行 三木洋一郎 北川周子 細川 淳嗣 川原田 淳 馬本 勉 今泉 敏
  • Organizer: 第9回医療系eラーニング全国交流会
  • Place of Presentation: 自治医科大学
  • Year and Date: 2015-01-24 – 2015-01-25
• [Presentation] Epidemiological study of the suicide trend and the life item ―Tokyo study ― (2014)
  • Author(s): Inoue K, Fukunaga T, MasakiM, Iida T, Wakatsuki T, Miyaoka T, Hashioka S, Wake R, Tanaka I, Fujita Y, Takeshita H, Fujita Y, Horiguchi J, Okazaki Y.
  • Organizer: X International scientific-practical conference. Kazakhstan, Semey.
  • Place of Presentation: タンザニア
  • Year and Date: 2014-08-09 – 2014-08-12
• [Presentation] Inoue K, Miyaoka T, Takeshita H, Iida T, Wakatsuki T, Fujita Y, Hashioka S, Wake R, TanakaI, Ezoe S, Fujita Y, Fukunaga T, Okazaki Y, Horiguchi J. (2014)
  • Author(s): Suggestion of specific suicide prevention measures based on the discussion about suicide trend of recent years in Japan.
  • Organizer: X International scientific-practical conference. Kazakhstan, Semey.
  • Place of Presentation: タンザニア
  • Year and Date: 2014-08-09 – 2014-08-12