The role of mitoNEET on the regulation of mitochondrial function in skeletal muscle failure
Project/Area Number |
26350879
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Applied health science
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Research Institution | Hokkaido University |
Principal Investigator |
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Co-Investigator(Kenkyū-buntansha) |
筒井 裕之 九州大学, 医学研究院, 教授 (70264017)
松島 将士 九州大学, 大学病院, 助教 (80552869)
横田 卓 北海道大学, 医学研究科, 助教 (90374321)
|
Research Collaborator |
FURIHATA Takaaki
TAKADA Shingo
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
|
Keywords | ミトコンドリア / 骨格筋不全 / 鉄代謝 |
Outline of Final Research Achievements |
In various chronic disease model mice, exercise capacity was reduced, skeletal muscle abnormalities such as mitochondrial dysfunction in the skeletal muscle and fiber type switch occurred, iron content within mitochondria was increased, and oxidative stress was enhanced. In mice deleted mitoNEET, we newly created, iron content within mitochondria was increased, oxidative stress was enhanced, and mitochondrial morphology and function was impaired, which resulted in the reduced exercise capacity. There were no differences in the known protein associated with iron homeostasis in mitochondria. In the analysis by protein interaction, we found that mitoNEET combined with cytosolic protein X associated with iron homeostasis and mitochondrial inner membrane protein Y associated with transportation of some substances into mitochondria.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes.2016
Author(s)
Mizushima, W., Takahashi , H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K.I., Tsutsui, H. and Hatakeyama, S.
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Journal Title
J. Mol. Cell. Cardiol.
Volume: 100
Pages: 43-53
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Tyrosine kinase FYN negatively regulates NOX4 in cardiac remodeling.2016
Author(s)
Matsushima S, Kuroda J, Zhai P, Liu T, Ikeda S, Nagarajan N, Oka S, Yokota T, Kinugawa S, Hsu C, Li H , Tsutsui H, Sadoshima J.
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Journal Title
Journal of Clinical Investigation
Volume: 126
Issue: 9
Pages: 3403-3416
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Dipeptidyl peptidase-4 inhibitor improved exercise capacity and mitochondrial biogenesis in mice with heart failure via activation of GLP-1 receptor signaling.2016
Author(s)
Takada S, Masaki Y, Kinugawa S, Matsumoto J, Furihata T, Mizushima W, Kadoguchi T, Fukushima A, Homma T, Takahashi M, Harashima S, Matsushima S, Yokota T, Tanaka S, Okita K, Tsutsui H
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Journal Title
Cardiovasc Res
Volume: 111
Issue: 4
Pages: 338-347
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] Direct renin inhibitor ameliorated insulin resistance by improving insulin signaling and oxidative stress in the skeletal muscle from post-infarct heart failure in mice.2016
Author(s)
Fukushima A, Kinugawa S, Takada S, Matsumoto J, Furihata T, Mizushima W, Tsuda M, Yokota T, Matsushima S, Okita K, Tsutsui H
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Journal Title
Eur J Pharmacol
Volume: 779
Pages: 147-156
DOI
NAID
Related Report
Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
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[Journal Article] AST-120 ameliorates lowered exercise capacity and mitochondrial biogenesis in the skeletal muscle from mice with chronic kidney disease via reducing oxidative stress.2015
Author(s)
Nishikawa M, Ishimori N, Takada S, Saito A, Kadoguchi T, Furihata T, Fukushima A, Matsushima S, Yokota T, Kinugawa S, Tsutsui H
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Journal Title
Nephrol Dial Transplant.
Volume: in press
Issue: 6
Pages: 182-188
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Serum brain-derived neurotrophic factor level predicts adverse clinical outcomes in patients with heart failure2015
Author(s)
Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Takada S, Kadoguchi T, Oba K, Okita K, Tsutsui H
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Journal Title
J Card Fail
Volume: 21
Issue: 4
Pages: 300-306
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Angiotensin II can directly induce mitochondrial dysfunction, decrease oxidative fibre number and induce atrophy in mouse hindlimb skeletal muscle.2015
Author(s)
Kadoguchi T, Kinugawa S, Takada S, Fukushima A, Furihata T, Homma T, Masaki Y, Mizushima W, Nishikawa M, Takahashi M, Yokota T, Matsushima S, Okita K, Tsutsui H
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Journal Title
Exp Physiol
Volume: 100
Issue: 3
Pages: 312-322
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Intramyocellular lipid is increased in the skeletal muscle of patients with dilated cardiomyopathy with lowered exercise capacity.2014
Author(s)
Hirabayashi K, Kinugawa S, Yokota T, Takada S, Fukushima A, Suga T, Takahashi M, Ono T, Morita N, Omokawa M, Harada K, Oyama-Manabe N, Shirato H, Matsushima S, Okita K, Tsutsui H
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Journal Title
International Journal of Cardiology
Volume: 176
Issue: 3
Pages: 1110-1112
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] (Pro)renin receptor in skeletal muscle is involved in the development of insulin resistance associated with postinfarct heart failure in mice2014
Author(s)
Fukushima A, Kinugawa S, Takada S, Matsushima S, Sobirin MA, Ono T, Takahashi M, Suga T, Homma T, Masaki Y, Furihata T, Kadoguchi T, Yokota T, Okita K, Tsutsui H
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Journal Title
American Journal of Physiology Endocrinology and Metabolism
Volume: 307
Issue: 6
Pages: E503-E514
DOI
Related Report
Peer Reviewed
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[Journal Article] Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice.2014
Author(s)
Takada S, Hirabayashi K, Kinugawa S, Yokota T, Matsushima S, Suga T, Kadoguchi T, Fukushima A, Homma T, Mizushima W, Masaki Y, Furihata T, Katsuyama R, Okita K, Tsutsui H
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Journal Title
European Journal of Pharmacology
Volume: 740
Pages: 690-696
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] Combination of exercise training and diet restriction normalizes limited exercise capacity and impaired skeletal muscle function in diet-induced diabetic mice.2014
Author(s)
Suga T, Kinugawa S, Takada S, Kadoguchi T, Fukushima A, Homma T, Masaki Y, Furihata T, Takahashi M, Sobirin MA, Ono T, Hirabayashi K, Yokota T, Tanaka S, Okita K, Tsutsui H.
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Journal Title
Endocrinology
Volume: 155
Issue: 1
Pages: 68-80
DOI
Related Report
Peer Reviewed
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[Presentation] Mitochondrial protein acetylation in skeletal muscle was associated with exercise intolerance in heart failure after myocardial infarction.2016
Author(s)
Tsuda M, Kinugawa S, Takada S, Fukushima A, Yokota T, Mizushima W, Furihata T, Matsumoto J, Katayama T, Nakajima T, Maekawa S, Nambu H, Shirakawa R, Kakutani N, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Session 2016.
Place of Presentation
New Orleans, USA
Related Report
Int'l Joint Research
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[Presentation] Brain-derived neurotrophic factor plays an important role of exercise capacity and mitochondrial function in the skeletal muscle in mice with post-infarct heart failure.2016
Author(s)
Nakajima T, Kinugawa S, Matsumoto J, Takada S, Furihata T, Tsuda M, Katayama T, Nambu H, Shirakawa R, Maekawa S, Kakutani N, Mizushima W, Yokota T, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Session 2016.
Place of Presentation
New Orleans, USA
Related Report
Int'l Joint Research
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[Presentation] The activation of glucagon-like peptide-1 improves the mitochondrial abnormalities in skeletal muscle and exercise intolerance in heart failure mice.2016
Author(s)
Katayama T, Takada S, Masaki Y, Kinugawa S, Matsumoto J, Nakajima T, Tsuda M, Furihata T, Mizushima W, Fukushima A, Yokota T, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Session 2016
Place of Presentation
New Orleans, USA
Related Report
Int'l Joint Research
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[Presentation] Desruption of mitoNEET, outer mitochondrial membrane protein, increases mitochondrial iron content in the heart2015
Author(s)
Furihata T, Kinugawa S, Takada S, Matsushima S, Mizushima W, Yokota T, Tsutsui H
Organizer
Desruption of mitoNEET, outer mitochondrial membrane protein, increases mitochondrial iron content in the heart
Place of Presentation
神戸国際会議場(兵庫県神戸市)
Year and Date
2015-12-11
Related Report
Int'l Joint Research
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[Presentation] Brain-derived neurotrophic factor could regulate mitochondrial function in the skeletal muscle through ampk-pgc1a signaling in heart failure mice2015
Author(s)
Matsumoto J, Kinugawa S, Takada S, Furihata T, Mizushima W, Tsuda M, Nakajima T, Katayama T, Fukuoka R, Yokota T, Matsushima S, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Session 2015
Place of Presentation
Orlando(USA)
Year and Date
2015-11-09
Related Report
Int'l Joint Research
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[Presentation] Deletion of NAD(P)H oxidase 2 attenuates angiotensin II-induced skeletal muscle atrophy2015
Author(s)
Mizushima W, Kinugawa S, Kadoguchi T, Takada S, Fukushima A, Furihata T, Matsumoto J, Tsuda M, Yokota T, Matsushima S, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Session 2015
Place of Presentation
Orlando(USA)
Year and Date
2015-11-09
Related Report
Int'l Joint Research
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[Presentation] Recombinant human BDNF can mimic effects of exercise training in mice2015
Author(s)
Takada S, Kinugawa S, Matsushima S, Yokota T, Mizushima W, Furihata T, Matsumoto J, Tsuda M, Fukushima A, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Session 2015
Place of Presentation
Orlando(USA)
Year and Date
2015-11-09
Related Report
Int'l Joint Research
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[Presentation] Disruption of outer mitochondrial membrane protein, mitoNEET, increases mitochondrial iron content in the heart.2014
Author(s)
Furihata T, Kinugawa S, Matsushima S, Takada S, Fukushima A, Mizushima W, Kadoguchi T, Masaki Y, Yokota T, Tsutsui H
Organizer
American Heart Association Scientific Session 2014
Place of Presentation
Chicago, USA
Year and Date
2014-11-16
Related Report
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[Presentation] Angiotensin II directly induces mitochondrial dysfunction and atrophy in the skeletal muscle.2014
Author(s)
Kadoguchi T, Kinugawa S, Fukushima A, Furihata T, Suga T, Takada S, Mizushima W, Kudo M, Matsumoto J, Tsuda M, Nishikawa M, Yokota T, Matsushima S, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Session 2014.
Place of Presentation
Chicago, USA
Year and Date
2014-11-16
Related Report
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[Presentation] Brain-derived neurotrophic factor maintains exercise capacity and mitochondrial function in the skeletal muscle through AMPK-PGC-1α signaling2014
Author(s)
Takada S, Kinugawa S, Matsushima S, Mizushima W, Fukushima A, Furihata T, Kadoguchi T, Yokota T, Suga T, Okita K, Tsutsui H
Organizer
American Heart Association Scientific Session 2014.
Place of Presentation
Chicago, USA
Year and Date
2014-11-16
Related Report
-
[Presentation] AST-120 ameliorates lowered exercise capacity and mitochondrial dysfunction of the skeletal muscle in mice with chronic kidney disease via reducing oxidative stress2014
Author(s)
Nishikawa M, Ishimori N, Takada S, Saito A, Kadoguchi T, Furihata T, Fukushima A, Matsushima S, Yokota T, Kinugawa S, Tsutsui H
Organizer
American Heart Association Scientific Session 2014.
Place of Presentation
Chicago, USA
Year and Date
2014-11-16
Related Report
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[Presentation] Sesamin improves lowered exercise capacity, mitochondrial dysfunction in the skeletal muscle from high fat diet-induced diabetis mice2014
Author(s)
Takada S, Kinugawa S, Takemoto D, Masaki Y, Kadoguchi T, Yokota T, Matsushima S, Fukushima A, Homma T, Furihata T, Suga T, Katsuyama R, Ono Y, Shibata H, Okita K, Tsutsui H
Organizer
50th European Association for the Study of Diabetes Annual Meetings
Place of Presentation
Vienna, Austria
Year and Date
2014-09-18
Related Report
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[Presentation] Dipeptidyl peptidase-4 inhibitor improved exercise capacity in association with switching to oxidative skeletal muscle fiber type in mice with post-infarct heart failure2014
Author(s)
Masaki Y, Kinugawa S, Takada S, Kadoguchi T, Fukushima A, Homma T, Furihata T, Katsuyama R, Suga T, Takahashi M, Yokota T, Matsushima S, Okita K, Tsutsui H
Organizer
74th American Diabetic Association Scientific Seissions
Place of Presentation
San Francisco, USA
Year and Date
2014-06-14
Related Report
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