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A Common Genetic Variant of the Chromogranin A-derived peptide Catestatin is Associated with Atherogenesis and Hypertension in a Japanese Population

Research Project

Project/Area Number 26350881
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionUniversity of Tsukuba

Principal Investigator

TAKEKOSHI Kazuhiro  筑波大学, 医学医療系, 教授 (40261804)

Co-Investigator(Kenkyū-buntansha) 中田 由夫  筑波大学, 医学医療系, 准教授 (00375461)
島野 仁  筑波大学, 医学医療系, 教授 (20251241)
前田 清司  筑波大学, 体育系, 教授 (30282346)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2014: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Keywordsカテスタチン / catestatin
Outline of Final Research Achievements

CHGA gives rise to cardiovascular/metabolic regulatory peptides, such as catestatin (CST).While CST is a potent inhibitor of catecholamine secretion. Recently, several SNPs were identified in the CST domains of CHGA locus in different populations. Among the discovered SNPs, CST variant allele Ser-364 was associated with blood pressure alteration. In this study, we examined whether this CST variant alleles exist and influence cardiovascular and metabolic phenotypes in Japanese population. In 343 participants, the minor allele frequency of CST variant Ser-364 was 6.10%. The presence of Ser-364 allele was associated with increased in baPWV (an index of systemic arterial stiffness), suggesting an initiation and/or progression atherogenesis and hypertension. The Ser-364 allele was also associated with elevated systolic blood pressure and pulse pressure, consistent with increased baPWV.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2015 Other

All Int'l Joint Research (1 results) Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results)

  • [Int'l Joint Research] Indian Institute of Technology Madras(INDIA)

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 日本人におけるカテスタチン多型と動脈硬化の関連2015

    • Author(s)
      Youngju Choi他
    • Journal Title

      Endocrine Journal

      Volume: 62 Pages: 797-804

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant

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Published: 2014-04-04   Modified: 2018-03-22  

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