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Establishment of non-invasive pathology evaluation for nonalcoholic fatty liver disease using functional imaging

Research Project

Project/Area Number 26350882
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionUniversity of Tsukuba

Principal Investigator

ISOBE Tomonori  筑波大学, 医学医療系, 教授 (70383643)

Co-Investigator(Kenkyū-buntansha) 蕨 栄治  筑波大学, 医学医療系, 講師 (70396612)
正田 純一  筑波大学, 医学医療系, 教授 (90241827)
岡本 嘉一  筑波大学, 医学医療系, 講師 (90420083)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Keywords生活習慣病 / 非アルコール性脂肪性肝疾患(NAFLD) / MRI / MRS / 超音波 / 非アルコール性脂肪性肝疾患
Outline of Final Research Achievements

Nonalcoholic fatty liver disease (NAFLD) is divided into two types: simple fatty liver and Non-alcoholic steatohepatitis. Pathology evaluation for NAFLD has been mainly performed by liver biopsy, blood test and form information of diagnostic imaging. In this study, an objective diagnostic index was established by functional imaging information from a point of view of a relationship to pathology. Moreover, a new method was proposed for the evaluation using functional information of the liver and the skeletal muscle which control glycolipid metabolism. This method is our original and not has been presented in previous studies.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2017 2016 2015 2014

All Journal Article (8 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (7 results) Book (2 results)

  • [Journal Article] Effect of biological factors on successful measurements with skeletal-muscle 1H-MRS2016

    • Author(s)
      Isobe T, Okamoto Y, Hirano Y, Ando H, Takada K, Sato E, Shinoda K, Tadano K, Takei H, Kamizawa S, Mori Y, Suzuki H
    • Journal Title

      Journal of Therapeutics and Clinical Risk Management

      Volume: 20 Pages: 1133-1137

    • DOI

      10.2147/tcrm.s84371

    • NAID

      120007129513

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] NAFLD診断における肝の脂肪量と線維化の評価2016

    • Author(s)
      磯辺智範, 岡本嘉一, 平野雄二, 正田純一
    • Journal Title

      月間インナービジョン

      Volume: 31(6)(通巻363号) Pages: 102-103

    • Related Report
      2016 Annual Research Report
  • [Journal Article] MRSの基礎から臨床まで2016

    • Author(s)
      磯辺智範, 山本哲哉, 阿久津 博義, 佐藤英介, 只野喜一, 増本智彦, 榮 武二, 松村 明
    • Journal Title

      医学物理

      Volume: 36 Pages: 85-91

    • NAID

      130005312335

    • Related Report
      2016 Annual Research Report
  • [Journal Article] 拡散テンソル画像の基本原理と画像解析2016

    • Author(s)
      佐藤英介, 磯辺智範, 山本哲哉, 松村 明
    • Journal Title

      医学物理

      Volume: 36 Pages: 97-102

    • NAID

      130005312334

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Influence of echo time in quantitative proton MR spectroscopy using LCModel2015

    • Author(s)
      Yamamoto T, Isobe T, Akutsu H, Masumoto T, Ando H, Sato E, Takada K, Anno I, Matsumura A
    • Journal Title

      Magn Reson Imaging

      Volume: 33 Pages: 644-648

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Acceleration training for managing nonalcoholic fatty liver disease: a pilot study2014

    • Author(s)
      Oh S, Shida T, Sawai A, Maruyama T, Eguchi K, Isobe T, Okamoto Y, Someya N, Tanaka K, Arai E, Tozawa A, Shoda J
    • Journal Title

      Therapeutics and Clinical Risk Management

      Volume: 10 Pages: 925-936

    • DOI

      10.2147/tcrm.s68322

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Changes in diffusion tensor imaging (DTI) eigenvalues of skeletal muscle due to hybrid exercise training Magnetic Resonance Imaging.2014

    • Author(s)
      Okamoto Y, Kemp GJ, Isobe T, Sato E, Hirano Y, Shoda J, Minami M.
    • Journal Title

      Magnetic Resonance Imaging 2014,

      Volume: 32 Issue: 10 Pages: 1297-1300

    • DOI

      10.1016/j.mri.2014.07.002

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] 骨格筋のMRI2014

    • Author(s)
      岡本嘉一, 磯辺智範, 平野雄二
    • Journal Title

      映像情報メディカル

      Volume: 46 Pages: 71-78

    • Related Report
      2014 Research-status Report
  • [Presentation] Proton MRSを用いた髄液内乳酸濃度の非侵襲的測定法の確立2017

    • Author(s)
      磯辺智範, 只野喜一, 平野雄二, 高倉 有, 佐藤英介, 増本智彦, 榮 武二
    • Organizer
      日本放射線技術学会第63回関東支部研究発表大会
    • Place of Presentation
      栃木県総合文化センター(栃木県宇都宮市)
    • Year and Date
      2017-01-28
    • Related Report
      2016 Annual Research Report
  • [Presentation] Diffusion-weighted imaging using Local Excitation Method to Be Successful Assessment of Myometrial Invasion by Endometrial Carcinoma2016

    • Author(s)
      Ando H, Matumoto K, Takehara H, Isobe T, Sakae T, Masuda Y
    • Organizer
      第72回日本放射線技術学会総会学術大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-04-14
    • Related Report
      2016 Annual Research Report
  • [Presentation] 非アルコール性脂肪性肝疾患における骨格筋の異常2016

    • Author(s)
      志田隆史, 丸山 剛, 呉 世昶, 秋山 健太郎, 磯辺智範, 平野雄二, 岡本嘉一, 正田純一
    • Organizer
      第6回肥満と消化器疾患研究会
    • Place of Presentation
      京王プラザホテル(東京都新宿区)
    • Related Report
      2016 Annual Research Report
  • [Presentation] 脂肪性肝疾患の病態評価におけるMRSおよびT1rhoの有用性の検討2015

    • Author(s)
      磯辺智範,高倉 有,平野雄二,蘇 リナ,志田隆史,佐藤英介,只野喜一,岡本嘉一,正田純一
    • Organizer
      日本放射線技術学会第62回関東支部研究発表大会
    • Place of Presentation
      ホテルメトロポリタン長野(長野)
    • Year and Date
      2015-12-12
    • Related Report
      2015 Research-status Report
  • [Presentation] NAFLDの診断におけるT1rhoの臨床的有用性の検討2015

    • Author(s)
      磯辺 智範,蘇 リナ,岡本 嘉一,平野雄二,高倉 有,佐藤英介,正田純一
    • Organizer
      第43回日本磁気共鳴医学会大会
    • Place of Presentation
      東京ドームホテル(東京)
    • Year and Date
      2015-09-10
    • Related Report
      2015 Research-status Report
  • [Presentation] 筋肉トレーニングによる骨格筋細胞内拡散変化の追跡2014

    • Author(s)
      岡本嘉一 磯辺智範 平野雄二 正田純一 南 学
    • Organizer
      第42回日本磁気共鳴医学会
    • Place of Presentation
      京都
    • Year and Date
      2014-09-18 – 2014-09-20
    • Related Report
      2014 Research-status Report
  • [Presentation] Non-Invasive Assessment of Ectopic Fat in Non-Alcoholic Fatty Liver Disease Using 1H-MRS2014

    • Author(s)
      Isobe T, Okamoto Y, Hirano Y, Sihda T, Sato E, Shoda J
    • Organizer
      The Section for Magnetic Resonance Technologists(SMRT)23st Annual Meeting
    • Place of Presentation
      Milano, Italy
    • Year and Date
      2014-05-10 – 2014-05-12
    • Related Report
      2014 Research-status Report
  • [Book] 診療画像技術学IIb MRI2016

    • Author(s)
      磯辺智範
    • Total Pages
      255
    • Publisher
      医療科学社
    • Related Report
      2016 Annual Research Report
  • [Book] 医学のあゆみ 非アルコール性脂肪性肝疾患のあらたな非侵襲的評価ツール: MRSとCAP2015

    • Author(s)
      磯辺智範, 正田純一
    • Total Pages
      70
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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