Assessment of new serum markers and web-based questionnaires in the prediction of lifestyle-related disease

• Project/Area Number: 26350888
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Osaka University
• Principal Investigator: NISHIDA MAKOTO 大阪大学, 保健センター, 准教授 (00379273)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000); Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 内科 / 生活習慣病 / 内臓脂肪 / 健康診断 / 生活習慣病リスク / 血清マーカー / 動脈硬化リスク / 頸動脈エコー

Outline of Final Research Achievements

We started measurements of waist circumference (WC), visceral fat, and carotid ultrasonography from 2004, in the vanguard of Japanese medical checkup centers, and accumulated data over 10 years. Cross-sectional analyses revealed accumulation of visceral fat in female smokers, and associations between smoking and novel serum marker FGF21 and α-klotho. Not only smoking but short sleeping hours and psychological stress was associated with serum α-klotho. Longitudinal analyses revealed strong association of 10 years-changes in BMI or WC with 10 years-changes in risk factors. Smoking cessation did not increase BMI or WC and was considered a useful interventional method for preventing risk factors. In addition, improvement of sleep may be a useful interventional target.

Research Products

• [Journal Article] Association between N-terminal pro-brain natriuretic peptide and adiponectin in healthy Japanese men. (2016)
  • Author(s): Nakanishi K, Nishida M, Yamamoto R, Koseki M, Moriyama T, Yamauchi-Takihara K.
  • Journal Title: Clin Chim Acta Volume: 460 Pages: 138-141
  • DOI: 10.1016/j.cca.2016.06.029
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 敷地内全面禁煙に向けての取り組みとその効果について (2016)
  • Author(s): 石山 奈緒美(大阪大学保健センター), 梅野 有希, 川村 淳子, 明石 美智子, 中西 香織, 熊谷 一代, 村井 教子, 姫ヶ迫 由美, 小関 正博, 山本 陵平, 西田 誠, 守山 敏樹, 瀧原 圭子
  • Journal Title: CAMPUS HEALTH Volume: 53 Pages: 166-168
  • Peer Reviewed
• [Journal Article] Klotho-related molecules upregulated by smoking habit in apparently healthy men: A cross sectional study. (2015)
  • Author(s): K. Nakanishi, M. Nishida, M. Harada, T. Ohama, N. Kawada, M. Murakami, T. Moriyama, K. Yamauchi-Takihara.
  • Journal Title: Scientific Reports Volume: 5 Issue: 1 Pages: 14230-14230
  • DOI: 10.1038/srep14230
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 青年期における血圧と肥満度の関連性への性差の影響 大阪大学学生健康診断データより (2015)
  • Author(s): 川田 典孝, 川村 淳子, 村井 教子, 中西 香織, 大濱 透, 西田 誠, 守山 敏樹, 瀧原 圭子
  • Journal Title: CAMPUS HEALTH Volume: 52 Pages: 279-281
• [Journal Article] Reference Interval for the Apolipoprotein B-48 Concentration in Healthy Japanese Individuals (2014)
  • Author(s): Masuda D, Nishida M, Arai T, Hanada H, Yoshida H, Yamauchi-Takihara K, Moriyama T, Tada N, Yamashita S.
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 21 Issue: 6 Pages: 618-627
  • DOI: 10.5551/jat.22558
  • NAID: 130004444752
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Smoking Associates With Visceral Fat Accumulation Especially in Women (2014)
  • Author(s): Nakanishi K, Nishida M, Ohama T, Moriyama T, Yamauchi-Takihara K.
  • Journal Title: Circulation Journal Volume: 78 Issue: 5 Pages: 1259-1263
  • DOI: 10.1253/circj.CJ-13-1134
  • NAID: 130003391073
  • ISSN: 1346-9843, 1347-4820
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] Association of Cardiovascular Risk Factors and Life Style with the Changes of Waist Circumference ― 10 Years Follow-up ― (2017)
  • Author(s): Makoto Nishida, Kaori Nakanishi, Masahiro, Koseki, Keiko Takihara
  • Organizer: 第81 回日本循環器学会学術集会
  • Place of Presentation: 石川県立音楽堂ほか（金沢市）
  • Year and Date: 2017-03-17
• [Presentation] The association between N-terminal pro-brain natriuretic peptide and adiponectin in healthy subjects (2016)
  • Author(s): Kaori Nakanishi, Makoto Nishida, Masahiro Koseki, Keiko Yamauchi-Takihara
  • Organizer: 第33回国際心臓研究学会日本部会
  • Place of Presentation: 東京コンベンションホール（東京都）
  • Year and Date: 2016-12-16
  • Int'l Joint Research
• [Presentation] 喫煙による老化促進におけるクロトー関連分子の関与について (2016)
  • Author(s): 中西香織, 西田誠, 瀧原圭子
  • Organizer: 第20回日本適応医学会学術集会
  • Place of Presentation: 東京コンベンションホール（東京都）
  • Year and Date: 2016-12-16
• [Presentation] 10年間のBMI・腹囲増減に伴う健康障害と生活習慣の関連 (2016)
  • Author(s): 梅野 有希, 西田 誠, 川村 淳子, 村井 教子, 熊谷 一代, 中西 香織, 小関 正博, 山本 陵平, 守山 敏樹, 瀧原 圭子
  • Organizer: 第54回全国大学保健管理研究集会
  • Place of Presentation: 大阪国際会議場（大阪市）
  • Year and Date: 2016-10-05
• [Presentation] Smoking Upregulates The Serum Levels of Klotho-Related Molecules (2016)
  • Author(s): Kaori Nakanishi, Makoto Nishida, Masaaki Murakami, Toshiki Moriyama, Keiko Yamauchi-Takihara
  • Organizer: ATS 2016 International Conference
  • Place of Presentation: Moscone Convention Center (San Francisco, USA)
  • Year and Date: 2016-05-13
  • Int'l Joint Research
• [Presentation] Smoking Affects the Associations of Klotho-related Molecules, FGF-21 and Klotho, with Metabolic Disorders and Anti-inflammatory Network (2016)
  • Author(s): Makoto Nishida, Kaori Nakanishi, Masahiro Koseki, Keiko Takihara
  • Organizer: 第80回日本循環器学会学術集会
  • Place of Presentation: 仙台国際センターほか(仙台市)
  • Year and Date: 2016-03-18
• [Presentation] 中高年男性における男性ホルモンとメタボリック症候群の縦断的研究 (2016)
  • Author(s): 宮川 康, 上田 倫央, 惣田 哲次, 竹澤 健太郎, 福原 慎一郎, 木内 寛, 西田 誠, 守山 敏樹, 瀧原 圭子, 辻村 晃, 野々村 祝夫
  • Organizer: 第20 回日本生殖内分泌学会学術集会
  • Place of Presentation: 神戸国際会議場(神戸市)
  • Year and Date: 2016-01-09
• [Presentation] ジュース摂取量は蛋白尿の予測因子である (2015)
  • Author(s): 山本 陵平, 守山 敏樹, 川村 淳子, 小寺 幸江, 明石 美智子, 中西 香織, 小関 正博, 西田 誠, 水田 一郎, 工藤 喬, 瀧原 圭子
  • Organizer: 第53回全国大学保健管理研究集会
  • Place of Presentation: 盛岡市民文化ホール(盛岡市)
  • Year and Date: 2015-09-09