| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2014: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
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| Outline of Final Research Achievements |
The genetic basis for diversity in non-alcoholic fatty liver diseases (NAFLD) in young adults was investigated by analyzing the single nucleotide polymorphisms (SNPs). Of the SNPs of the genes that have reported to be associated with the development of NAFLD, TM6SF2 SNP but not PNPLA3 SNP was significantly associated with NAFLD. Furthermore, the TM6SF2 SNP was associated with prognosis of NAFLD and low-density lipoprotein cholesterol levels in plasma. On the other hand, the PNPLA3 SNP was associated with leukocyte fraction, suggesting its association with pathogenesis of non-alcoholic steatohepatitis (NASH).
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