| Project/Area Number |
26350896
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
後藤 孔郎 大分大学, 医学部, 助教 (10457624)
柴田 洋孝 大分大学, 医学部, 教授 (20245484)
千葉 政一 大分大学, 医学部, 助教 (20457633)
加隈 哲也 大分大学, 保健管理センター, 准教授 (80343359)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ストレス |
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| Outline of Final Research Achievements |
In the present study, we have examined that a stress-induced hyperphagia in diet-induced obese (DIO) mice might affect their body adiposity and related metabolic factors. DIO mice were divided into the group of feeding ad libitum and cold water stress groups. After stress, body adiposity, metabolic parameters were assessed. The group of cold water stress increased body adiposity compared to control groups. In addition, water stress also increased leptin levels in WAT. Furthermore, the group of cold water stress groups increased neuropeptide Y levels in hypothalamus compared to controls. In conclusion, cold water stress appeared to regulate body adiposity, metabolic factors in DIO obese mice.
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