The relationship between stress-induced hyperphagia and obesity
| Project/Area Number |
26350896
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Oita University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
後藤 孔郎 大分大学, 医学部, 助教 (10457624)
柴田 洋孝 大分大学, 医学部, 教授 (20245484)
千葉 政一 大分大学, 医学部, 助教 (20457633)
加隈 哲也 大分大学, 保健管理センター, 准教授 (80343359)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ストレス |
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| Outline of Final Research Achievements |
In the present study, we have examined that a stress-induced hyperphagia in diet-induced obese (DIO) mice might affect their body adiposity and related metabolic factors. DIO mice were divided into the group of feeding ad libitum and cold water stress groups. After stress, body adiposity, metabolic parameters were assessed. The group of cold water stress increased body adiposity compared to control groups. In addition, water stress also increased leptin levels in WAT. Furthermore, the group of cold water stress groups increased neuropeptide Y levels in hypothalamus compared to controls. In conclusion, cold water stress appeared to regulate body adiposity, metabolic factors in DIO obese mice.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] GLP-1 regulates beta-cell mass through brain-derived neurotrophic factor neurons in non-diabetic obese rats.2017
Author(s)
Ando H, Gotoh K, Fujiwara K, Mitsutomi K, Shimasaki T, Itateyama E, Anai M, Chiba S, Masaki T, Seike M, Kakuma T, Shibata H
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Journal Title
Scientific Reports
Volume: 3
Issue: 1
Pages: 807-817
DOI
Related Report
Peer Reviewed
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[Journal Article] Fulminant Type 1 Diabetes Mellitus with Anti-programmed Cell Death-1 Therapy2016
Author(s)
Okamoto M, Okamoto M, Gotoh K, Masaki T, Ozeki Y, Ando H, Anai M, Sato A, Yoshida Y, Ueda S, Kakuma T, Shibata H.
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Journal Title
Journal of Diabetes Investigation
Volume: 7
Pages: 915-918
Related Report
Peer Reviewed / Open Access
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[Journal Article] Pore alterations of the endotheliallining of rat fenestrated intestinal capillaries exposed to acute stress.2016
Author(s)
Aosa T, Chiba S, Kitamura H, Ina K, Tatsukawa S, Moriwaki C, Wei H, Gotoh K, Masaki T, Kakuma T, Shibata H, Fujikura Y.
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Journal Title
Histol Histopathol.
Volume: 31
Pages: 807-817
Related Report
Peer Reviewed
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[Journal Article] Mast Cells Play an Important Role in the Pathogenesis of Hyperglycemia-Induced Atrial Fibrillation.2016
Author(s)
Uemura K, Kondo H, Ishii Y, Kobukata M, Haraguchi M, Imamura T, Otsubo T, Ikebe-Ebata Y, Abe I, Ayabe R, Saito S, Aoki K, Nagano-Torigoe Y, Akioka H,Shinohara T, Teshima Y, Masaki T, Yufu K, Nakagawa M, Takahashi N.
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Journal Title
J Cardiovasc Electrophysiol.
Volume: 27
Pages: 981-989
Related Report
Peer Reviewed
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[Journal Article] A clinical approach to brown adipose tissue in the para-aortic area of the human thorax.2015
Author(s)
Wei H, Chiba S, Moriwaki C, Kitamura H, Ina K, Aosa T, Tomonari K, Gotoh K, Masaki T, Katsuragi I, Noguchi H, Kakuma T, Hamaguchi K, Shimada T, Fujikura Y, Shibata H.
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Journal Title
Related Report
Peer Reviewed / Open Access
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[Presentation] 肥満症における食事療法2014
Author(s)
正木 孝幸
Organizer
第35回日本肥満学会
Place of Presentation
宮崎県宮崎市シーガイアコンベンションセンター
Year and Date
2014-10-24 – 2014-10-25
Related Report
Invited
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