| Project/Area Number |
26350900
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Nara Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
井上 芳光 大阪国際大学, 人間科学部, 教授 (70144566)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 運動強度 / 運動時間 / 脱水率 / 血栓形成 / VWF / ADAMTS13 / 加齢 / ＶＷＦ / ＡＤＡＭＴＳ１３ / 脱水 / 老化 / 脱水量 / フォンビルブランド因子 / 高齢者 / 若年成人 |
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| Outline of Final Research Achievements |
We aimed to quantify factors influencing thrombus formation at the time of sports activities, and compared different exercise intensities, exercise times and the extent of dehydration and thrombosis. The relationship with the formation-related factor (VWF, ADAMTS 13) was also examined. As a result, thrombus formation-related factors (VWF/ADAMTS 13) indicating the tendency of thrombosis during exercise were affected by exercise intensity rather than exercise time. In addition, it was recognized that there was an "exercise intensity threshold" at which the thrombosis tendency increased significantly at about 55%VO2max. Finally, considering the relationship between the dehydration rate and thrombus formation-related factors, the difference in the dehydration rate due to the difference in ambient temperature did not affect the change in thrombus formation-related factors. These results suggest that the thrombotic tendency seen during exercise is due to exercise intensity.
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