The investigations of the effects of fatty acids consumption or direct administration on the functions of cardiovascular system.

• Project/Area Number: 26350904
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Josai University
• Principal Investigator: Keizo Kasono 城西大学, 薬学部, 教授 (90177387)
• Co-Investigator(Kenkyū-buntansha): 野部 浩司 昭和大学, 薬学部, 教授 (30276612) ; 竹之内 康広 城西大学, 薬学部, 助手 (30582233) ; 大竹 一男 城西大学, 薬学部, 助教 (50337482)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 糖尿病 / 糖尿病合併症 / n-3系多価不飽和脂肪酸 / エイコサペンタエン酸 / 血管内皮機能 / 脂肪酸 / 血管内皮細胞 / n-3系多可不飽和脂肪酸 / 低酸素トレーニング / 血管内皮機能障害 / EPA / DHA

Outline of Final Research Achievements

<1> The administration of palmitoleic acid (POA) for 2 weeks improved the insulin resistance and reduced the plasma glucose levels in diabetic model mice (KKA-y). It was speculated that the administration of POA compensatory increased the relaxation response induced by PPAR-δ.<2> Eicosapentaenoic acid (EPA) dose-dependently decreased the up-regulated protein levels of VCAM-1 and ICAM-1 induced by TNF-α in human aortic endothelial cells.<3> It is speculated that fish oil supplementation reduces the cardiovascular loading induced by increase of Ht during hypoxic training without blunting the improvement of endurance performance.

Research Products

• [Journal Article] Effects of Fish Oil Supplement on Normobaric Hypoxic Training of the University Male Ekiden Runners (2016)
  • Author(s): 櫛部静二、小林 悟、竹之内康広、金 賢珠、新井尚之、 野部浩司、大竹一男、白幡 晶、加園恵三
  • Journal Title: Journal of Lipid Nutrition Volume: 25 Issue: 1 Pages: 61-74
  • DOI: 10.4010/jln.25.61
  • NAID: 130005151388
  • ISSN: 1343-4594, 1883-2237
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 2型糖尿病モデルマウス（KKAy）における血管機能障害に及ぼすエイコサペンタエン酸エチルの治療効果 (2014)
  • Author(s): 竹ノ内康広
  • Organizer: 第130回日本薬理学会関東部会
  • Place of Presentation: 東京
  • Year and Date: 2014-07-05