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The investigations of the effects of fatty acids consumption or direct administration on the functions of cardiovascular system.

Research Project

Project/Area Number 26350904
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionJosai University

Principal Investigator

Keizo Kasono  城西大学, 薬学部, 教授 (90177387)

Co-Investigator(Kenkyū-buntansha) 野部 浩司  昭和大学, 薬学部, 教授 (30276612)
竹之内 康広  城西大学, 薬学部, 助手 (30582233)
大竹 一男  城西大学, 薬学部, 助教 (50337482)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords糖尿病 / 糖尿病合併症 / n-3系多価不飽和脂肪酸 / エイコサペンタエン酸 / 血管内皮機能 / 脂肪酸 / 血管内皮細胞 / n-3系多可不飽和脂肪酸 / 低酸素トレーニング / 血管内皮機能障害 / EPA / DHA
Outline of Final Research Achievements

<1> The administration of palmitoleic acid (POA) for 2 weeks improved the insulin resistance and reduced the plasma glucose levels in diabetic model mice (KKA-y). It was speculated that the administration of POA compensatory increased the relaxation response induced by PPAR-δ.<2> Eicosapentaenoic acid (EPA) dose-dependently decreased the up-regulated protein levels of VCAM-1 and ICAM-1 induced by TNF-α in human aortic endothelial cells.<3> It is speculated that fish oil supplementation reduces the cardiovascular loading induced by increase of Ht during hypoxic training without blunting the improvement of endurance performance.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (2 results)

All 2016 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Effects of Fish Oil Supplement on Normobaric Hypoxic Training of the University Male Ekiden Runners2016

    • Author(s)
      櫛部静二、小林 悟、竹之内康広、金 賢珠、新井尚之、 野部浩司、大竹一男、白幡 晶、加園恵三
    • Journal Title

      Journal of Lipid Nutrition

      Volume: 25 Issue: 1 Pages: 61-74

    • DOI

      10.4010/jln.25.61

    • NAID

      130005151388

    • ISSN
      1343-4594, 1883-2237
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] 2型糖尿病モデルマウス(KKAy)における血管機能障害に及ぼすエイコサペンタエン酸エチルの治療効果2014

    • Author(s)
      竹ノ内康広
    • Organizer
      第130回日本薬理学会関東部会
    • Place of Presentation
      東京
    • Year and Date
      2014-07-05
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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