The relationship between G-protein coupled Estrogen Receptor: GPER and arterial stiffening

• Project/Area Number: 26350906
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Kokugakuin University
• Principal Investigator: Hayashi Koichiro 國學院大學, 人間開発学部, 准教授 (90433474)
• Co-Investigator(Kenkyū-buntansha): 家光 素行 立命館大学, スポーツ健康科学部, 教授 (90375460)
• Co-Investigator(Renkei-kenkyūsha): Miyachi Motohiko 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 健康増進研究部, 部長 (60229870) ; Murakami Haruka 国立研究開発法人医薬基盤・健康・栄養研究所, 国立健康・栄養研究所 健康増進研究部, 研究員 (20344880)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: GPER / 遺伝子多型 / 動脈硬化 / 運動 / 身体活動

Outline of Final Research Achievements

I examined the hypothesis that genotypes of “G-protein Coupled Estrogen Receptor: GPER) might influence arterial stiffening and the ability of regular exercise to decrease arterial stiffness in healthy Japanese men and women (age 18-85, n=784). In rs3808350 polymorphism (in the promoter region, A→G), the carotid arterial stiffness of individuals who have GG type was significantly lower than that of individuals who have AA and AG type. Aerobic capacity did not influence the relationship the polymorphism and arterial stiffness of carotid artery. Also, rs3808350 polymorphism was significantly related with BMI and blood glucose level. These results suggest that polymorphism of GPER (rs3808350) candidate for determining arterial stiffness and the risk factor for coronary artery diseases such as BMI and blood glucose, but these relationships are independent of cardiorespiratory fitness.

Research Products

• [Journal Article] 女性の体力と動脈硬化 (2015)
  • Author(s): 林貢一郎
  • Journal Title: WHITE Volume: 3（1） Pages: 100-105
• [Presentation] Endothelial function in high school female rhythmic gymnasts: effects of eating disorder and mood states (2016)
  • Author(s): Hayashi, k., Nakamura, F., Watanabe, R., Takamatsu, A., Omori, T.
  • Organizer: The 63nd annual meeting of the American College of Sport Medi
  • Place of Presentation: Boston, USA
  • Year and Date: 2016-05-31
  • Int'l Joint Research
• [Presentation] 月経周期と循環器系機能への影響 (2016)
  • Author(s): 林 貢一郎
  • Organizer: 日本臨床スポーツ医学会公開シンポジウム（第Ⅰ部 月経周期とホルモンの影響）
  • Place of Presentation: 東京都中央区
  • Year and Date: 2016-01-30
  • Invited
• [Presentation] エストロゲン受容体β遺伝子多型は日本人女性の有酸素性作業能力に影響する (2015)
  • Author(s): 林貢一郎，家光素行，村上晴香，真田樹義，丸藤祐子，川上諒子，宮地元彦
  • Organizer: 第70回 日本体力医学会大会
  • Place of Presentation: 和歌山市
  • Year and Date: 2015-09-18
• [Presentation] Endothelial function in high school female rhythmic gymnasts: impact of psychosomatic stress and menstrual status (2015)
  • Author(s): Hayashi, k., Nakamura, F., Watanabe, R., Takamatsu, A., Omori, T.
  • Organizer: The 20th annual congress of the European College of Sport Science
  • Place of Presentation: Malmo, Sweden
  • Year and Date: 2015-06-24
  • Int'l Joint Research
• [Presentation] Estrogen receptor-beta gene polymorphism affects cardiorespiratory fitness in Japanese women (2015)
  • Author(s): Hayashi, K., Iemitsu, M., Murakami, H., Sanada, K., Gando Y., Kawakami R., Miyachi, M.
  • Organizer: The 62nd annual meeting of the American College of Sport Medicine
  • Place of Presentation: Sandiego, USA
  • Year and Date: 2015-05-26
  • Int'l Joint Research
• [Presentation] Effects of physical and psychological stress on salivary nitric oxide in young men (2015)
  • Author(s): Sone, R., Hayashi, K., Shimizu, K., Hanaoka, Y., Watanabe, K.
  • Organizer: The 62nd annual meeting of the American College of Sport Medicine
  • Place of Presentation: Sandiego, USA
  • Year and Date: 2015-05-26
  • Int'l Joint Research