Personalized prevention for lifestyle-related diseases in control of reactive oxygen species

• Project/Area Number: 26350908
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Showa University
• Principal Investigator: KOKAZE Akatsuki 昭和大学, 医学部, 教授 (70271583)
• Co-Investigator(Kenkyū-buntansha): 木庭 新治 昭和大学, 医学部, 教授 (20276546)
• Project Period (FY): 2014-04-01 – 2019-03-31
• Project Status: Completed (Fiscal Year 2018)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2017: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: ミトコンドリアDNA / 遺伝子多型 / コーヒー / 肝障害 / 赤血球パラメーター / 血清クロール / 眼圧 / 長寿 / 多型 / コーヒー引用 / ミトコンドリアDNA多型 / 電解質濃度 / コーヒー飲用 / 交互作用 / ミトコンドリア遺伝子多型 / 生活習慣 / 活性酸素 / 行動変容 / 遺伝的リスク値

Outline of Final Research Achievements

Longevity-associated mitochondrial DNA 5178 C/A polymorphism modifies the effects of cigarette smoking on the risk of liver injury and those of coffee consumption on erythrocytic parameters, risk of liver injury, serum chloride level and intraocular pressure. These findings will contribute the establishment of personalized behavior modification program for the prevention of lifestyle-related diseases.

Academic Significance and Societal Importance of the Research Achievements

Mt5178C/A多型と喫煙習慣との肝障害リスクに対する交互作用、Mt5178C/A多型とコーヒー飲用との赤血球パラメーター、肝障害リスク、血清クロール値、眼圧に対する交互作用は、生活習慣病のためのテーラーメイド予防法の開発に役立つと思われる。

Research Products

• [Journal Article] NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the association of coffee consumption with serum chloride levels in male Japanese health checkup examinees: an exploratory cross-sectional analysis. (2018)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ochiai H, Shirasawa T, Yoshimoto T, Minoura A, Oikawa K, Satoh M, Hoshino H, Takashima Y
  • Journal Title: Nutrients Volume: 10 Issue: 10 Pages: 1344-1344
  • DOI: 10.3390/nu10101344
  • Peer Reviewed / Open Access
• [Journal Article] Mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on elevated levels of serum liver enzymes in male Japanese health check-up examinees: an exploratory cross-sectional study (2016)
  • Author(s): Kokaze A, Yoshida M, Ishikawa M, Matsunaga N, Karita K, Ochiai H, Shirasawa T, Nanri H, Mitsui K, Hoshimo H, Takashima Y
  • Journal Title: J Physiol Anthropol Volume: 35 Issue: 1 Pages: 15-23
  • DOI: 10.1186/s40101-016-0098-2
  • Peer Reviewed / Open Access
• [Journal Article] NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies effects of cigarette smoking on risk of elevated levels of serum liver enzyme in male Japanese health check-up examinees: a cross-sectional study. (2014)
  • Author(s): Kokaze A, Yoshida M, Ishikawa M, Matsunaga N, Karita K, Ohtsu T, Ochiai H, Shirasawa T, Nanri H, Baba Y, Ohtsu I, Hoshino H, Takashima Y.
  • Journal Title: Tobacco Induced Diseases Volume: 12 Issue: 1 Pages: 11-11
  • DOI: 10.1186/1617-9625-12-11
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Longevity-associated mitochondrial DNA 5178 C/A polymorphism modulates the effects of coffee consumption on erythrocytic parameters in Japanese men: an exploratory cross-sectional analysis. (2014)
  • Author(s): Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, Ochiai H, Shirasawa T, Nanri H, Saga N, Ohtsu I, Hoshino H, Takashima Y.
  • Journal Title: Journal of Physiological Anthropology Volume: 33 Issue: 1 Pages: 37-37
  • DOI: 10.1186/1880-6805-33-37
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Presentation] 長寿関連ミトコンドリアDNA多型におけるコーヒー飲用と眼圧との関係解析 (2019)
  • Author(s): 小風 暁、吉田正雄、石川 守、苅田香苗、落合裕隆、白澤貴子、吉本隆彦、箕浦 明、佐藤正夫、高島 豊
  • Organizer: 第29回日本疫学会学術総会
• [Presentation] 長寿関連ミトコンドリアDNA多型におけるコーヒー飲用と血清電解質濃度との関係解析 (2018)
  • Author(s): 小風 暁、石川 守、吉田正雄、苅田香苗、落合裕隆、白澤貴子、吉本隆彦、箕浦 明、佐藤正夫、高島 豊
  • Organizer: 第88回日本衛生学会総会
• [Presentation] 長寿関連ミトコンドリアDNA多型におけるコーヒー飲用と肝機能検査成績との関係解析 (2015)
  • Author(s): 小風 暁、吉田正雄、石川 守、苅田香苗、大津忠弘、落合裕隆、白澤貴子、南里妃名子、佐藤正夫、星野祐美、高島 豊
  • Organizer: 第85回日本衛生学会学術総会
  • Place of Presentation: 和歌山市
  • Year and Date: 2015-03-26 – 2015-03-28
• [Presentation] 長寿関連ミトコンドリアDNA多型とコーヒー飲用との赤血球パラメーターへの交互作用 (2014)
  • Author(s): 小風 暁、大津忠弘、落合裕隆、白澤貴子、南里妃名子
  • Organizer: 第61回昭和大学学士会総会
  • Place of Presentation: 品川区
  • Year and Date: 2014-12-06