Metabolic analysis of lipid metabolism in the anorexigenic peptide and exercise

• Project/Area Number: 26350912
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Applied health science
• Research Institution: Hoshi University
• Principal Investigator: Takenoya Fumiko 星薬科大学, 薬学部, 准教授 (30234412)
• Co-Investigator(Kenkyū-buntansha): 亀井 淳三 星薬科大学, 薬学部, 教授 (40161236) ; 塩田 清二 星薬科大学, 薬学部, 教授 (80102375) ; 平子 哲史 人間総合科学大学, 人間科学部, 助教 (90644261)
• Co-Investigator(Renkei-kenkyūsha): Kageyama Haruaki 桐生大学, 医療保健学部, 准教授 (00433839)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: ペプチド / 糖・脂質代謝 / 運動療法 / メタボローム解析 / 抗肥満作用 / マウス / 抗肥満ペプチド / 点鼻投与 / 脂質代謝 / メタボロ－ム解析 / 自由運動 / 摂食量 / 運動量

Outline of Final Research Achievements

Galanin-like peptide has an anti-obesity effec. We try obese cancellation using this peptide and exercise. Treatment of GALP with ob/ob and DIO mice decreased food intake. Infusion of anorexigenic peptid and exercise are it hoped that it becomes new exercise therapy of obesity people.

Research Products

• [Journal Article] Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue. (2016)
  • Author(s): Hirako S, Wada N, Kageyama H, Takenoya F, Izumida Y, Kim H, Iizuka Y, Matsumoto A, Okabe M, Kimura A, Suzuki M, Yamanaka S, Shioda S.
  • Journal Title: Sci Rep. Volume: 19;6 Pages: 21481-21481
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice. (2016)
  • Author(s): KAGEYAMA H, SHIBA K, HIRAKO S, WADA N, YAMANAKA S, NOGI Y, TAKENOYA F, NONAKA N, HIRAKO S, INOUE S, SHIODA S
  • Journal Title: Sci Rep. Volume: 6 Issue: 1 Pages: 28200-28200
  • DOI: 10.1038/srep28200
  • Peer Reviewed / Open Access
• [Journal Article] Pleiotropic and retinoprotective functions of PACAP. (2016)
  • Author(s): SHIODA S, TAKENOYA F, WADA N, HIRABAYASHI T, SEKI T, NAKAMACHI T
  • Journal Title: Anat Sci Int. Volume: 91 Issue: 4 Pages: 313-324
  • DOI: 10.1007/s12565-016-0351-0
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Autonomic nervous system-mediated effects of GALP on energy metabolism (2016)
  • Author(s): HIRAKO S, WADA N, KAGEYAMA H, TAKENOYA F, INOUE S, SHIODA S
  • Journal Title: Folia Pharmacologica Japonica Volume: 148 Issue: 1 Pages: 23-27
  • DOI: 10.1254/fpj.148.23
  • NAID: 130005164793
  • ISSN: 0015-5691, 1347-8397
  • Peer Reviewed / Open Access
• [Journal Article] Bihavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8. (2016)
  • Author(s): WADA N, YAMANAKA S, SHIOBATO J, RAKWAL R, HIRAKO S, IIZUKA Y, KIM H, MATSUMOTO A, KIMURA A, TAKENOYA F, YASUNAGA G, SHIODA S
  • Journal Title: Genom Data Volume: 10 Pages: 38-50
  • DOI: 10.1016/j.gdata.2016.09.004
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons. (2016)
  • Author(s): Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
  • Journal Title: Neuroscience. Volume: 320 Pages: 183-193
  • DOI: 10.1016/j.neuroscience.2016.02.002
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] The relationship between aquaglyceroporin expression and development of fatty liver in diet-induced obesity and ob/ob mice. (2015)
  • Author(s): Hirako S, Wakayama Y, Kim H, Iizuka Y, Matsumoto A, Wada N, Kimura A, Okabe M, Sakagami J, Suzuki M, Takenoya F, Shioda S
  • Journal Title: Obes Res Clin Pract Volume: Epub ahead of print Issue: 6 Pages: 38-50
  • DOI: 10.1016/j.orcp.2015.12.001
  • Peer Reviewed / Open Access
• [Journal Article] Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons. (2015)
  • Author(s): Takenoya F, Wang L, Kageyama H, Hirako S, Wada N, Hashimoto H, Ueta Y, Sakagami J, Nonaka N, Shioda S.
  • Journal Title: J Mol Neurosci. Volume: 56 Pages: 789-798
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons. (2015)
  • Author(s): Takenoya F, Wang L, Kageyama H, Hirako S, Wada N, Hashimoto H, Ueta Y, Sakagami J, Nonaka N, Shioda S.
  • Journal Title: J Mol Neurosci Volume: 57 Issue: 4 Pages: 789-798
  • DOI: 10.1007/s12031-015-0501-1
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Leptin and its receptors (2014)
  • Author(s): Wada N, Hirako S, Takenoya F, Kageyama H, Okabe M, Shioda S.
  • Journal Title: J Chem Neuroanat Volume: 61-62 Pages: 191-199
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Galanin-like peptide prevent obesity by control of food intake and energy metabolism. (2014)
  • Author(s): Hirako S, Takenoya F, Kageyama H, Wada N, Okabe M, Shioda S.
  • Journal Title: Pharm Anal Acta Volume: 5 Issue: 05 Pages: 1-5
  • DOI: 10.4172/2153-2435.1000297
  • Peer Reviewed / Open Access
• [Presentation] カーフ・レイズ後の人工炭酸泉部分浴による下腿部筋硬度の変化 (2016)
  • Author(s): 山本憲志、和田匡史、竹ノ谷文子、橋本眞明
  • Organizer: 人工炭酸泉研究会
  • Place of Presentation: 東京
  • Year and Date: 2016-12-02
• [Presentation] Yamamoto N, Hashimoto M, Wada T, Takenoya F (2016)
  • Author(s): ARTIFICAL CO2-WATER BATHING IMPROVED MUSCLE FLEXIBILITY AND HARDNESS IN MALE COLLEGE STUDENTS
  • Organizer: The 21st Annual Congress of the ECSS
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-06-06
  • Int'l Joint Research
• [Presentation] Wada T, Yamamoto N, Wada M, Shintaku Y, Iwahara F, Takenoya, F (2016)
  • Author(s): A POSSIBILITY TO PROMOTE THE PHYSICAL RECOVERY BY SLEEP AFTER CO2-WATER BATHING IN ATHLETES
  • Organizer: The 21st Annual Congress of the ECSS
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2016-06-06
• [Presentation] ガラニン様ペプチド(GALP)による末梢組織でのエネルギー代謝調節作用およびそのメカニズムの解明. (2016)
  • Author(s): 平子哲史、和田亘弘、影山晴秋、竹ノ谷文子、塩田清二.
  • Organizer: 第70会日本栄養・食糧学会大会
  • Place of Presentation: 神戸
  • Year and Date: 2016-05-13
• [Presentation] Intranasal administration of GALP suppressed the lipid accumulation in the liver. 13th International Congress on Obesity (2016)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S.
  • Organizer: 13th International Congress on Obesity
  • Place of Presentation: Vancouver, Canada.
  • Year and Date: 2016-05-01
  • Int'l Joint Research
• [Presentation] Intranasal administration of GALP suppressed the lipid accumulation in the liver (2016)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S.
  • Organizer: 13th International Congress on Obesity
  • Place of Presentation: Canada
  • Year and Date: 2016-05-01
• [Presentation] Neuroprotective effect of PACAP on spinal cord injury through CRMP2 protein (2015)
  • Author(s): Shioda, S., Takenoya, F., Hori, M., Shibato, J., Nakamachi, T., and Rakwal, R.
  • Organizer: 12th international symposium on VIP/PACAP and related peptides
  • Place of Presentation: カッパドキア、トルコ
  • Year and Date: 2015-09-21
• [Presentation] GALPによる自律神経系を介した脂質代謝調節機構 (2015)
  • Author(s): 平子哲史・竹ノ谷文子・和田亘弘・塩田清二
  • Organizer: 第12回GPCR研究会
  • Place of Presentation: 東京
  • Year and Date: 2015-05-15
• [Presentation] Effect of intranasal GALP on obesity and hepatic lipid metabolism in obese mice. (2015)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S.
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: Yohama, Japan
  • Year and Date: 2015-05-14
• [Presentation] Effect of GALP on lipid metabolism in liver (2015)
  • Author(s): Hirako S, Takaenoya F, Wada N,Kageyama H, Shioda S
  • Organizer: 第20回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸、国際会議場
  • Year and Date: 2015-03-21 – 2015-03-23
  • Invited
• [Presentation] Neuropeptide W-induced hypophagia is mediated through corticotropin-releasing hormone-containing neurons (2015)
  • Author(s): Takaenoya F, Hirako S, Wada N,Kageyama H, Shioda S
  • Organizer: 第20回日本解剖学会総会・全国学術集会
  • Place of Presentation: 神戸，国際会議場
  • Year and Date: 2015-03-21 – 2015-03-23
  • Invited
• [Presentation] Autonomic nervous system-mediated effects of GALP on energy metabolism in liver (2015)
  • Author(s): Shioda S, Hirako S, Wada N, Takenoya F
  • Organizer: 第88回日本薬理学会
  • Place of Presentation: 愛知、名古屋国際会議場
  • Year and Date: 2015-03-18 – 2015-03-20
  • Invited
• [Presentation] Opioid receptors in the lateral hypothalamus play a critical role in the regulation of feeding behavior (2015)
  • Author(s): Ikeda H, Yonemochi N, Yang L, Yamamoto S, Ikegami M, Takenoya F, Shioda S, Nagase S, Kamei J
  • Organizer: The 38th Annual Meeting of the Japan Neuroscience Society
  • Place of Presentation: koube, Japan
  • Year and Date: 2015-01-28 – 2015-01-31
• [Presentation] Galanin-like peptide (galp) facilitates thermogenesis via synthesis of prostaglandin e2 by astrocytes. (2014)
  • Author(s): Takenoya F, Kageyama H, Hirako S, Wada N, Watanabe J, Ryushi T, Shioda S
  • Organizer: 44th Annual meeting Society for Neuroscience
  • Place of Presentation: Washington, DC
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Galanin-like peptide (GALP) have the anti-obesity effect and control of energy metabolism via the sympathetic nervous system (2014)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Kimura A, Okabe M, Shioda S
  • Organizer: 44th Annual meeting Society for Neuroscience
  • Place of Presentation: Washington, DC
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Hepatic lipid accumulation is ameliorated by a whale oil feeding in obese KK mice (2014)
  • Author(s): Hirako S, Kim HJ, Iizuka Y, Matsumoto A, Wada N, Takenoya F, Okabe M, Suzuki M, Tokoro H, Shioda S
  • Organizer: 3rd International Conference on Nutraceutical and Cosmetic Sciences
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 2014-11-11 – 2014-11-12
• [Presentation] Effect of GALP on lipid metabolism and body weight regulation (2014)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Kimura A, Okabe M, Shioda S
  • Organizer: Obesity week 2014
  • Place of Presentation: Boston, MA
  • Year and Date: 2014-11-02 – 2014-11-07
• [Presentation] 摂食調節ペプチドGALP点鼻投与による脂質代謝改善メカニズムの解明 (2014)
  • Author(s): 平子哲史・竹ノ谷文子・影山晴秋・和田亘弘・木村愛・岡部まい・塩田清二
  • Organizer: 第35回日本肥満学会
  • Place of Presentation: 宮崎、シーガイヤコンベンションセンター
  • Year and Date: 2014-10-24 – 2014-10-25
• [Presentation] Energy metabolism regulation by intracerebroventricular and intranasal administration of GALP (2014)
  • Author(s): Hirako S, Kageyama H, Takaenoya F, Wada N, Kimura A, Okabe M, Shioda S
  • Organizer: 20th International Symposium on Regulatory Peptides
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2014-09-07 – 2014-09-10
• [Presentation] Galanin-like peptide (GALP) stimutates thermogenesis through glial cell in brain (2014)
  • Author(s): Wada N, Kageyama H, Ohsaka T, Hirako S, Watanabe J, Sakagami J, Takaenoya F, Shioda S
  • Organizer: 20th International Symposium on Regulatory Peptides
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2014-09-07 – 2014-09-10
• [Presentation] Effect of Galanin-like peptide (GALP) and spontaneous exercise on energy metabolism in mouse (2014)
  • Author(s): akaenoya F, Kageyama H, Hirako S, Wada N, Shioda S
  • Organizer: 20th International Symposium on Regulatory Peptides
  • Place of Presentation: Kyoto, Japan
  • Year and Date: 2014-09-07 – 2014-09-10
• [Presentation] ガラニン様ペプチド(GALP)による肥満症・脂質異常症の予防効果及びその機序 (2014)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第46回日本動脈硬化学会総会・学術集会
  • Place of Presentation: 東京、京王プラザホテル
  • Year and Date: 2014-07-10 – 2014-07-11
• [Presentation] Interactive effect galanin-like peptide (GALP) and spontaneous exercise on energy metabolism. (2014)
  • Author(s): Takenoya F, Kageyama H, Hirako S, Ota E, Wada N, Yamamoto N, Ryushi T, Shioda S
  • Organizer: 19th Annual Congress of the ECSS
  • Place of Presentation: Amsterdam, Netherland
  • Year and Date: 2014-06-02 – 2014-06-05
• [Presentation] ガラニン様ペプチド(GALP)によるメタボリックシンドロームの予防・治療法の研究 (2014)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: 第68会日本栄養・食糧学会大会
  • Place of Presentation: 北海道、酪農学園大学
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] 神経ペプチドWの摂食抑制作用はマウス自発運動により消失する (2014)
  • Author(s): 和田亘弘・竹ノ谷文子・影山晴秋・平子哲史・太田英司・金高有里・塩田清二
  • Organizer: 第68会日本栄養・食糧学会大会
  • Place of Presentation: 北海道、酪農学園大学
  • Year and Date: 2014-05-30 – 2014-06-01
• [Presentation] ガラニン様ペプチドの末梢組織におけるエネルギー代謝制御機構の解明 (2014)
  • Author(s): 平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
  • Organizer: GPCR研究会
  • Place of Presentation: 東京、未来科学館
  • Year and Date: 2014-05-15 – 2014-05-19
• [Presentation] Galanin-like peptide (GALP) have anti-obesity effect via the activation of hepatic lipid metabolism (2014)
  • Author(s): Hirako S, Kageyama H, Takenoya F, Ota E, Wada N, Shioda S
  • Organizer: The 2014 obesity summit
  • Place of Presentation: London, UK
  • Year and Date: 2014-04-03
• [Book] 生命科学の未来を考える Biophilia 芳香療法 (2016)
  • Author(s): 竹ノ谷文子、塩田清二、他
  • Total Pages: 60
  • Publisher: アドスリー社
• [Book] 木楽社 (2016)
  • Author(s): 竹ノ谷文子、塩田清二、他
  • Total Pages: 335
  • Publisher: 地球とつながる暮らしのデザイン
• [Book] 特集 未病・健康ー病気にならないための衣・食・住そしてココロ (2016)
  • Author(s): 塩田清二、竹ノ谷文子、亀井淳三 他
  • Total Pages: 83
  • Publisher: Biophilia
• [Book] アンチエイジング医学の基礎と臨床 (2015)
  • Author(s): 藤英胤（編集）、塩田清二、竹ノ谷文子 他
  • Total Pages: 447
  • Publisher: メジカルビュー社
• [Book] Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research (2015)
  • Author(s): Yoshio Takei, Hironori Ando, Kazuyoshi Tsutsui (編集), Takenoya F, 他 (分担)
  • Total Pages: 380
  • Publisher: ELSEVIER Academic Press
• [Book] Neuropeptide GPCRs in neuroendocrinology (2014)
  • Author(s): Fumiko Takenoya, Haruaki Kageyama, Satoshi Hirako, Eiji Ota, Nobuhiro Wada, Tomoo Ryushi, Seiji Shioda
  • Total Pages: 825
  • Publisher: Frontiers
• [Book] スポーツアナトミー人体解剖生理学 (2014)
  • Author(s): 竹ノ谷文子・塩田清二
  • Total Pages: 202
  • Publisher: 丸善