• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Metabolic analysis of lipid metabolism in the anorexigenic peptide and exercise

Research Project

Project/Area Number 26350912
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionHoshi University

Principal Investigator

Takenoya Fumiko  星薬科大学, 薬学部, 准教授 (30234412)

Co-Investigator(Kenkyū-buntansha) 亀井 淳三  星薬科大学, 薬学部, 教授 (40161236)
塩田 清二  星薬科大学, 薬学部, 教授 (80102375)
平子 哲史  人間総合科学大学, 人間科学部, 助教 (90644261)
Co-Investigator(Renkei-kenkyūsha) Kageyama Haruaki  桐生大学, 医療保健学部, 准教授 (00433839)
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsペプチド / 糖・脂質代謝 / 運動療法 / メタボローム解析 / 抗肥満作用 / マウス / 抗肥満ペプチド / 点鼻投与 / 脂質代謝 / メタボロ-ム解析 / 自由運動 / 摂食量 / 運動量
Outline of Final Research Achievements

Galanin-like peptide has an anti-obesity effec. We try obese cancellation using this peptide and exercise. Treatment of GALP with ob/ob and DIO mice decreased food intake. Infusion of anorexigenic peptid and exercise are it hoped that it becomes new exercise therapy of obesity people.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (45 results)

All 2016 2015 2014

All Journal Article (11 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 11 results,  Open Access: 11 results,  Acknowledgement Compliant: 6 results) Presentation (27 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results) Book (7 results)

  • [Journal Article] Autonomic nervous system-mediated effects of galanin-like peptide on lipid metabolism in liver and adipose tissue.2016

    • Author(s)
      Hirako S, Wada N, Kageyama H, Takenoya F, Izumida Y, Kim H, Iizuka Y, Matsumoto A, Okabe M, Kimura A, Suzuki M, Yamanaka S, Shioda S.
    • Journal Title

      Sci Rep.

      Volume: 19;6 Pages: 21481-21481

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Anti-obesity effect of intranasal administration of galanin-like peptide (GALP) in obese mice.2016

    • Author(s)
      KAGEYAMA H, SHIBA K, HIRAKO S, WADA N, YAMANAKA S, NOGI Y, TAKENOYA F, NONAKA N, HIRAKO S, INOUE S, SHIODA S
    • Journal Title

      Sci Rep.

      Volume: 6 Issue: 1 Pages: 28200-28200

    • DOI

      10.1038/srep28200

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pleiotropic and retinoprotective functions of PACAP.2016

    • Author(s)
      SHIODA S, TAKENOYA F, WADA N, HIRABAYASHI T, SEKI T, NAKAMACHI T
    • Journal Title

      Anat Sci Int.

      Volume: 91 Issue: 4 Pages: 313-324

    • DOI

      10.1007/s12565-016-0351-0

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Autonomic nervous system-mediated effects of GALP on energy metabolism2016

    • Author(s)
      HIRAKO S, WADA N, KAGEYAMA H, TAKENOYA F, INOUE S, SHIODA S
    • Journal Title

      Folia Pharmacologica Japonica

      Volume: 148 Issue: 1 Pages: 23-27

    • DOI

      10.1254/fpj.148.23

    • NAID

      130005164793

    • ISSN
      0015-5691, 1347-8397
    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Bihavioral and omics analyses study on potential involvement of dipeptide balenine through supplementation in diet of senescence-accelerated mouse prone 8.2016

    • Author(s)
      WADA N, YAMANAKA S, SHIOBATO J, RAKWAL R, HIRAKO S, IIZUKA Y, KIM H, MATSUMOTO A, KIMURA A, TAKENOYA F, YASUNAGA G, SHIODA S
    • Journal Title

      Genom Data

      Volume: 10 Pages: 38-50

    • DOI

      10.1016/j.gdata.2016.09.004

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons.2016

    • Author(s)
      Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
    • Journal Title

      Neuroscience.

      Volume: 320 Pages: 183-193

    • DOI

      10.1016/j.neuroscience.2016.02.002

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] The relationship between aquaglyceroporin expression and development of fatty liver in diet-induced obesity and ob/ob mice.2015

    • Author(s)
      Hirako S, Wakayama Y, Kim H, Iizuka Y, Matsumoto A, Wada N, Kimura A, Okabe M, Sakagami J, Suzuki M, Takenoya F, Shioda S
    • Journal Title

      Obes Res Clin Pract

      Volume: Epub ahead of print Issue: 6 Pages: 38-50

    • DOI

      10.1016/j.orcp.2015.12.001

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons.2015

    • Author(s)
      Takenoya F, Wang L, Kageyama H, Hirako S, Wada N, Hashimoto H, Ueta Y, Sakagami J, Nonaka N, Shioda S.
    • Journal Title

      J Mol Neurosci.

      Volume: 56 Pages: 789-798

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons.2015

    • Author(s)
      Takenoya F, Wang L, Kageyama H, Hirako S, Wada N, Hashimoto H, Ueta Y, Sakagami J, Nonaka N, Shioda S.
    • Journal Title

      J Mol Neurosci

      Volume: 57 Issue: 4 Pages: 789-798

    • DOI

      10.1007/s12031-015-0501-1

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Leptin and its receptors2014

    • Author(s)
      Wada N, Hirako S, Takenoya F, Kageyama H, Okabe M, Shioda S.
    • Journal Title

      J Chem Neuroanat

      Volume: 61-62 Pages: 191-199

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Galanin-like peptide prevent obesity by control of food intake and energy metabolism.2014

    • Author(s)
      Hirako S, Takenoya F, Kageyama H, Wada N, Okabe M, Shioda S.
    • Journal Title

      Pharm Anal Acta

      Volume: 5 Issue: 05 Pages: 1-5

    • DOI

      10.4172/2153-2435.1000297

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] カーフ・レイズ後の人工炭酸泉部分浴による下腿部筋硬度の変化2016

    • Author(s)
      山本憲志、和田匡史、竹ノ谷文子、橋本眞明
    • Organizer
      人工炭酸泉研究会
    • Place of Presentation
      東京
    • Year and Date
      2016-12-02
    • Related Report
      2016 Annual Research Report
  • [Presentation] Yamamoto N, Hashimoto M, Wada T, Takenoya F2016

    • Author(s)
      ARTIFICAL CO2-WATER BATHING IMPROVED MUSCLE FLEXIBILITY AND HARDNESS IN MALE COLLEGE STUDENTS
    • Organizer
      The 21st Annual Congress of the ECSS
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-06-06
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Wada T, Yamamoto N, Wada M, Shintaku Y, Iwahara F, Takenoya, F2016

    • Author(s)
      A POSSIBILITY TO PROMOTE THE PHYSICAL RECOVERY BY SLEEP AFTER CO2-WATER BATHING IN ATHLETES
    • Organizer
      The 21st Annual Congress of the ECSS
    • Place of Presentation
      Vienna, Austria
    • Year and Date
      2016-06-06
    • Related Report
      2016 Annual Research Report
  • [Presentation] ガラニン様ペプチド(GALP)による末梢組織でのエネルギー代謝調節作用およびそのメカニズムの解明.2016

    • Author(s)
      平子哲史、和田亘弘、影山晴秋、竹ノ谷文子、塩田清二.
    • Organizer
      第70会日本栄養・食糧学会大会
    • Place of Presentation
      神戸
    • Year and Date
      2016-05-13
    • Related Report
      2016 Annual Research Report
  • [Presentation] Intranasal administration of GALP suppressed the lipid accumulation in the liver. 13th International Congress on Obesity2016

    • Author(s)
      Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S.
    • Organizer
      13th International Congress on Obesity
    • Place of Presentation
      Vancouver, Canada.
    • Year and Date
      2016-05-01
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Intranasal administration of GALP suppressed the lipid accumulation in the liver2016

    • Author(s)
      Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S.
    • Organizer
      13th International Congress on Obesity
    • Place of Presentation
      Canada
    • Year and Date
      2016-05-01
    • Related Report
      2015 Research-status Report
  • [Presentation] Neuroprotective effect of PACAP on spinal cord injury through CRMP2 protein2015

    • Author(s)
      Shioda, S., Takenoya, F., Hori, M., Shibato, J., Nakamachi, T., and Rakwal, R.
    • Organizer
      12th international symposium on VIP/PACAP and related peptides
    • Place of Presentation
      カッパドキア、トルコ
    • Year and Date
      2015-09-21
    • Related Report
      2015 Research-status Report
  • [Presentation] GALPによる自律神経系を介した脂質代謝調節機構2015

    • Author(s)
      平子哲史・竹ノ谷文子・和田亘弘・塩田清二
    • Organizer
      第12回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-15
    • Related Report
      2015 Research-status Report
  • [Presentation] Effect of intranasal GALP on obesity and hepatic lipid metabolism in obese mice.2015

    • Author(s)
      Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S.
    • Organizer
      12th Asian Congress of Nutrition
    • Place of Presentation
      Yohama, Japan
    • Year and Date
      2015-05-14
    • Related Report
      2015 Research-status Report
  • [Presentation] Effect of GALP on lipid metabolism in liver2015

    • Author(s)
      Hirako S, Takaenoya F, Wada N,Kageyama H, Shioda S
    • Organizer
      第20回日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸、国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Neuropeptide W-induced hypophagia is mediated through corticotropin-releasing hormone-containing neurons2015

    • Author(s)
      Takaenoya F, Hirako S, Wada N,Kageyama H, Shioda S
    • Organizer
      第20回日本解剖学会総会・全国学術集会
    • Place of Presentation
      神戸,国際会議場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Autonomic nervous system-mediated effects of GALP on energy metabolism in liver2015

    • Author(s)
      Shioda S, Hirako S, Wada N, Takenoya F
    • Organizer
      第88回日本薬理学会
    • Place of Presentation
      愛知、名古屋国際会議場
    • Year and Date
      2015-03-18 – 2015-03-20
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Opioid receptors in the lateral hypothalamus play a critical role in the regulation of feeding behavior2015

    • Author(s)
      Ikeda H, Yonemochi N, Yang L, Yamamoto S, Ikegami M, Takenoya F, Shioda S, Nagase S, Kamei J
    • Organizer
      The 38th Annual Meeting of the Japan Neuroscience Society
    • Place of Presentation
      koube, Japan
    • Year and Date
      2015-01-28 – 2015-01-31
    • Related Report
      2014 Research-status Report
  • [Presentation] Galanin-like peptide (galp) facilitates thermogenesis via synthesis of prostaglandin e2 by astrocytes.2014

    • Author(s)
      Takenoya F, Kageyama H, Hirako S, Wada N, Watanabe J, Ryushi T, Shioda S
    • Organizer
      44th Annual meeting Society for Neuroscience
    • Place of Presentation
      Washington, DC
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Galanin-like peptide (GALP) have the anti-obesity effect and control of energy metabolism via the sympathetic nervous system2014

    • Author(s)
      Hirako S, Kageyama H, Takaenoya F, Wada N, Kimura A, Okabe M, Shioda S
    • Organizer
      44th Annual meeting Society for Neuroscience
    • Place of Presentation
      Washington, DC
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Hepatic lipid accumulation is ameliorated by a whale oil feeding in obese KK mice2014

    • Author(s)
      Hirako S, Kim HJ, Iizuka Y, Matsumoto A, Wada N, Takenoya F, Okabe M, Suzuki M, Tokoro H, Shioda S
    • Organizer
      3rd International Conference on Nutraceutical and Cosmetic Sciences
    • Place of Presentation
      Tokyo, Japan
    • Year and Date
      2014-11-11 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of GALP on lipid metabolism and body weight regulation2014

    • Author(s)
      Hirako S, Kageyama H, Takaenoya F, Wada N, Kimura A, Okabe M, Shioda S
    • Organizer
      Obesity week 2014
    • Place of Presentation
      Boston, MA
    • Year and Date
      2014-11-02 – 2014-11-07
    • Related Report
      2014 Research-status Report
  • [Presentation] 摂食調節ペプチドGALP点鼻投与による脂質代謝改善メカニズムの解明2014

    • Author(s)
      平子哲史・竹ノ谷文子・影山晴秋・和田亘弘・木村愛・岡部まい・塩田清二
    • Organizer
      第35回日本肥満学会
    • Place of Presentation
      宮崎、シーガイヤコンベンションセンター
    • Year and Date
      2014-10-24 – 2014-10-25
    • Related Report
      2014 Research-status Report
  • [Presentation] Energy metabolism regulation by intracerebroventricular and intranasal administration of GALP2014

    • Author(s)
      Hirako S, Kageyama H, Takaenoya F, Wada N, Kimura A, Okabe M, Shioda S
    • Organizer
      20th International Symposium on Regulatory Peptides
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Galanin-like peptide (GALP) stimutates thermogenesis through glial cell in brain2014

    • Author(s)
      Wada N, Kageyama H, Ohsaka T, Hirako S, Watanabe J, Sakagami J, Takaenoya F, Shioda S
    • Organizer
      20th International Symposium on Regulatory Peptides
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] Effect of Galanin-like peptide (GALP) and spontaneous exercise on energy metabolism in mouse2014

    • Author(s)
      akaenoya F, Kageyama H, Hirako S, Wada N, Shioda S
    • Organizer
      20th International Symposium on Regulatory Peptides
    • Place of Presentation
      Kyoto, Japan
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Research-status Report
  • [Presentation] ガラニン様ペプチド(GALP)による肥満症・脂質異常症の予防効果及びその機序2014

    • Author(s)
      平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
    • Organizer
      第46回日本動脈硬化学会総会・学術集会
    • Place of Presentation
      東京、京王プラザホテル
    • Year and Date
      2014-07-10 – 2014-07-11
    • Related Report
      2014 Research-status Report
  • [Presentation] Interactive effect galanin-like peptide (GALP) and spontaneous exercise on energy metabolism.2014

    • Author(s)
      Takenoya F, Kageyama H, Hirako S, Ota E, Wada N, Yamamoto N, Ryushi T, Shioda S
    • Organizer
      19th Annual Congress of the ECSS
    • Place of Presentation
      Amsterdam, Netherland
    • Year and Date
      2014-06-02 – 2014-06-05
    • Related Report
      2014 Research-status Report
  • [Presentation] ガラニン様ペプチド(GALP)によるメタボリックシンドロームの予防・治療法の研究2014

    • Author(s)
      平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
    • Organizer
      第68会日本栄養・食糧学会大会
    • Place of Presentation
      北海道、酪農学園大学
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 神経ペプチドWの摂食抑制作用はマウス自発運動により消失する2014

    • Author(s)
      和田亘弘・竹ノ谷文子・影山晴秋・平子哲史・太田英司・金高有里・塩田清二
    • Organizer
      第68会日本栄養・食糧学会大会
    • Place of Presentation
      北海道、酪農学園大学
    • Year and Date
      2014-05-30 – 2014-06-01
    • Related Report
      2014 Research-status Report
  • [Presentation] ガラニン様ペプチドの末梢組織におけるエネルギー代謝制御機構の解明2014

    • Author(s)
      平子哲史・影山晴秋・竹ノ谷文子・太田英司・和田亘弘・塩田清二
    • Organizer
      GPCR研究会
    • Place of Presentation
      東京、未来科学館
    • Year and Date
      2014-05-15 – 2014-05-19
    • Related Report
      2014 Research-status Report
  • [Presentation] Galanin-like peptide (GALP) have anti-obesity effect via the activation of hepatic lipid metabolism2014

    • Author(s)
      Hirako S, Kageyama H, Takenoya F, Ota E, Wada N, Shioda S
    • Organizer
      The 2014 obesity summit
    • Place of Presentation
      London, UK
    • Year and Date
      2014-04-03
    • Related Report
      2014 Research-status Report
  • [Book] 生命科学の未来を考える Biophilia 芳香療法2016

    • Author(s)
      竹ノ谷文子、塩田清二、他
    • Total Pages
      60
    • Publisher
      アドスリー社
    • Related Report
      2016 Annual Research Report
  • [Book] 木楽社2016

    • Author(s)
      竹ノ谷文子、塩田清二、他
    • Total Pages
      335
    • Publisher
      地球とつながる暮らしのデザイン
    • Related Report
      2016 Annual Research Report
  • [Book] 特集 未病・健康ー病気にならないための衣・食・住そしてココロ2016

    • Author(s)
      塩田清二、竹ノ谷文子、亀井淳三 他
    • Total Pages
      83
    • Publisher
      Biophilia
    • Related Report
      2015 Research-status Report
  • [Book] アンチエイジング医学の基礎と臨床2015

    • Author(s)
      藤英胤(編集)、塩田清二、竹ノ谷文子 他
    • Total Pages
      447
    • Publisher
      メジカルビュー社
    • Related Report
      2015 Research-status Report
  • [Book] Handbook of Hormones: Comparative Endocrinology for Basic and Clinical Research2015

    • Author(s)
      Yoshio Takei, Hironori Ando, Kazuyoshi Tsutsui (編集), Takenoya F, 他 (分担)
    • Total Pages
      380
    • Publisher
      ELSEVIER Academic Press
    • Related Report
      2015 Research-status Report
  • [Book] Neuropeptide GPCRs in neuroendocrinology2014

    • Author(s)
      Fumiko Takenoya, Haruaki Kageyama, Satoshi Hirako, Eiji Ota, Nobuhiro Wada, Tomoo Ryushi, Seiji Shioda
    • Total Pages
      825
    • Publisher
      Frontiers
    • Related Report
      2014 Research-status Report
  • [Book] スポーツアナトミー人体解剖生理学2014

    • Author(s)
      竹ノ谷文子・塩田清二
    • Total Pages
      202
    • Publisher
      丸善
    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2018-03-22  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi