| Project/Area Number |
26350915
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Applied health science
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| Research Institution | Tokyo University of Technology |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
加柴 美里 東京工科大学, 教養学環, 准教授 (80338186)
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| Co-Investigator(Renkei-kenkyūsha) |
KINOSHITA Kosaku 日本大学, 医学部附属板橋病院, 教授 (90260968)
SAKURAI Atsusi 日本大学病院, 准教授 (40339320)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 酸化ストレス / コエンザイムQ10 / 遊離脂肪酸 / 尿酸 / プロサポシン / 心肺停止救急患者 / ALS / 敗血症 / 活性酸素 / 遊離脂肪酸量 / 酸化型コエンザイムQ10の割合 / 血漿遊離脂肪酸量 / パルミトレイン酸 / オレイン酸 / 筋萎縮性側索硬化症（ALS / 筋萎縮性側索硬化症（ALS） |
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| Outline of Final Research Achievements |
In order to find out risk factors determining the survival of patients, we measured plasma levels of oxidized form of coenzyme Q10 (%CoQ10) and free fatty acids and their compositions in patients with ALS and PCAS. These levels were significantly different from those in healthy controls, indicating a significant increase of oxidative stress in these patients. Time course changes indicated that %CoQ10 decreased in patients who discharged in a week but remained unchanged in patients who died. Plasma level of prosaposin, a coenzyme Q10 binding and transfer protein, increased significantly, suggesting that coenzyme Q10 is necessary in a critical condition. It is interesting plasma levels of prosaposin in normal people increase with age.
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