Does melatonin control advanced glycation end products (AGEs) and their receptor (RAGE) ?
| Project/Area Number |
26350917
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Doshisha University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2014-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | メラトニン / SaMT / 糖化ストレス / 蛋白糖化最終生成物(AGEs) / 睡眠 / 糖脂質代謝 / 糖尿病 / 蛋白糖化反応最終生成物（AGEs） / AGEs分解作用 / AGEs架橋切断 / 生活習慣 / 予防医学 / 蛋白糖化最終産物 |
|---|
| Outline of Final Research Achievements |
Glycative stress control includes 1. Prevention of advanced glycation end product (AGE) formation, 2. AGE breaking and 3. AGEs/RAGE (Receptor for AGE) signal control. In our experiment, melatonin did not showed prevention of AGE formation nor inhibition of AGEs/RAGE signal, but showed the enhancing action of AGE breaking. Furthermore, to evaluate melatonin secretion, we measured urine 6-OH-melatonin sulfate (SaMT), a melatonin metabolite, and found that human urine SaMT correlated to growth hormone/IGF-I secretion but were not detected in mouse urine. Melatonin seems to play a role in the mechanism that the high quality sleep reduces the glycative stress. Urine SaMT may contribute to evaluate the sleep quality.
|
Report
(4 results)
Research Products
(47 results)
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] Lower levels of insulin-like growth factor-1 standard deviation score are associated with histological severity of non-alcoholic fatty liver disease2014
Author(s)
Sumida Y, Yonei Y, Tanaka S, Mori K, Kanemasa K, Imai S, Taketani H, Hara T, Seko Y, Ishiba H, Okajima A, Yamaguchi K, Moriguchi M, Mitsuyoshi H, Yasui K, Minami M, Itoh
-
Journal Title
Hepatol Res
Volume: -
Issue: 7
Pages: 1-11
DOI
Related Report
Peer Reviewed / Open Access
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
