| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥2,600,000 (Direct Cost: ¥2,000,000、Indirect Cost: ¥600,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Outline of Final Research Achievements |
Glycative stress control includes 1. Prevention of advanced glycation end product (AGE) formation, 2. AGE breaking and 3. AGEs/RAGE (Receptor for AGE) signal control. In our experiment, melatonin did not showed prevention of AGE formation nor inhibition of AGEs/RAGE signal, but showed the enhancing action of AGE breaking. Furthermore, to evaluate melatonin secretion, we measured urine 6-OH-melatonin sulfate (SaMT), a melatonin metabolite, and found that human urine SaMT correlated to growth hormone/IGF-I secretion but were not detected in mouse urine. Melatonin seems to play a role in the mechanism that the high quality sleep reduces the glycative stress. Urine SaMT may contribute to evaluate the sleep quality.
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