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Identification of novel biomarkers for insulin resistance

Research Project

Project/Area Number 26350922
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Applied health science
Research InstitutionTokyo Metropolitan Geriatric Hospital and Institute of Gerontology

Principal Investigator

Fujita Yasunori  地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 主任研究員 (30515888)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsインスリン抵抗性 / バイオマーカー
Outline of Final Research Achievements

To identify novel biomarkers for insulin resistance, we performed a comprehensive gene expression analysis of C2C12 myotubes exposed to the saturated fatty acid, palmitate. We identified 38 genes encoding extracellular proteins whose expression was induced in response to palmitate. Among those genes, we focused on Ccl7 and Gdf15 as candidate genes of the biomarker. We measured serum concentrations of CCL7 and GDF15 in Zucker rats, a widely used animal model of obesity and type 2 diabetes. The serum levels of CCL7 and GDF15 were increased in Zucker-fatty rats compared with Zucker-lean rats. Moreover, serum CCL7 levels were positively correlated with body weight. On the other hand, serum GDF15 levels were strongly correlated with parameters of lipid and carbohydrate metabolism and renal function. Further studies are needed to determine the potential usefulness of serum CCL7 and GDF15 as novel biomarkers for insulin resistance.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (6 results)

All 2016 2015 2014

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 2 results) Presentation (4 results) (of which Int'l Joint Research: 1 results)

  • [Journal Article] Secreted growth differentiation factor 15 as a potential biomarker for mitochondrial dysfunctions in aging and age-related disorders2016

    • Author(s)
      Yasunori Fujita, Yu Taniguchi, Shoji Shinkai, Masashi Tanaka, Masafumi Ito
    • Journal Title

      Geriatr Gerontol Int

      Volume: 16 (Suppl. 1) Issue: S1 Pages: 17-29

    • DOI

      10.1111/ggi.12724

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] (2014) GDF15 is a novel biomarker to evaluate efficacy of pyruvate therapy for mitochondrial diseases2015

    • Author(s)
      Yasunori Fujita, Masafumi Ito, Toshio Kojima, Shuichi Yatsuga, Yasutoshi Koga, Masashi Tanaka
    • Journal Title

      Mitochondrion

      Volume: 20 Pages: 34-42

    • DOI

      10.1016/j.mito.2014.10.006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Presentation] Serum Concentrations of GDF15 Predict Mortality in a General Population of Older Japanese.2016

    • Author(s)
      Shoji Shinkai, Yu Taniguchi, Satoshi Seino, Akihiko Kitamura, Yasunori Fujita, Masashi Tanaka, Masafumi Ito.
    • Organizer
      2016 GSA Annual Scientific Meeting
    • Place of Presentation
      New Orleans (USA)
    • Year and Date
      2016-11-16
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 地域在住高齢者の血中GDF15と負の健康アウトカムとの関連解析2016

    • Author(s)
      藤田泰典、谷口優、新開省二、田中雅嗣、伊藤雅史
    • Organizer
      第39回日本基礎老化学会大会
    • Place of Presentation
      伊勢原市民文化会館(神奈川県・伊勢原市)
    • Year and Date
      2016-05-27
    • Related Report
      2016 Annual Research Report
  • [Presentation] 網羅的遺伝子発現解析よるミトコンドリア病の新規バイオマーカーの同定2014

    • Author(s)
      藤田泰典、伊藤雅史、小島俊男、八ツ賀秀一、古賀靖敏、田中雅嗣
    • Organizer
      第14回日本ミトコンドリア学会年会
    • Place of Presentation
      福岡
    • Year and Date
      2014-12-04
    • Related Report
      2014 Research-status Report
  • [Presentation] ミトコンドリア機能異常を反映するバイオマーカーの探索2014

    • Author(s)
      藤田泰典、伊藤雅史、小島俊男、八ツ賀秀一、古賀靖敏、田中雅嗣
    • Organizer
      第37回日本基礎老化学会大会
    • Place of Presentation
      愛知
    • Year and Date
      2014-06-26
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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