| Project/Area Number |
26350955
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Childhood science (childhood environment science)
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| Research Institution | National Institutes for Quantum and Radiological Science and Technology |
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Principal Investigator |
Morioka Takamitsu 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 主幹研究員(定常) (70253961)
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| Co-Investigator(Renkei-kenkyūsha) |
KAKINUMA Shizuko 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 部長 (20392219)
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| Research Collaborator |
SUNAOSHI Masaaki 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 研究員 (70756030)
SHANG Yi 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 研究員 (50533189)
TSURUOKA Chizuru 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 研究員 (60415411)
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | カロリー制限 / 放射線 / 消化管腫瘍 / がん予防 / 発がん |
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| Outline of Final Research Achievements |
It has been known that calorie restriction (CR) extends lifespan and prevents cancer. We previously reported that CR extended lifespan after radiation exposure in mouse model. However, there are few reports on the preventive effects of CR against radiation-associated tumors. Hence, we examined the cancer preventive effects of CR on radiation-induced intestinal tumors using familial adenomatous polyposis mouse model.
In this study, we found that juvenile-, young adult- or adult-onset CR inhibited the increase in body weights. CR also inhibited both the total number of tumor and tumor size. Especially, CR suppressed the tumor growth. Juvenile-onset CR was highly effective in reducing the risk for radiation-induced tumorigenesis. Young adult- and adult-onset CR also had the beneficial effect on prevention of radiation-induced tumors.
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