The cancer preventive effect of adult-onset calorie restriction on radiation induced tumor after childhood exposure.
Project/Area Number |
26350955
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Childhood science (childhood environment science)
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Research Institution | National Institutes for Quantum and Radiological Science and Technology |
Principal Investigator |
Morioka Takamitsu 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線影響研究部, 主幹研究員(定常) (70253961)
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Co-Investigator(Renkei-kenkyūsha) |
KAKINUMA Shizuko 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 部長 (20392219)
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Research Collaborator |
SUNAOSHI Masaaki 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 研究員 (70756030)
SHANG Yi 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 研究員 (50533189)
TSURUOKA Chizuru 量子科学技術研究開発機構, 放射線医学総合研究所・放射線影響研究部, 研究員 (60415411)
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Project Period (FY) |
2014-04-01 – 2018-03-31
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Project Status |
Completed (Fiscal Year 2017)
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Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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Keywords | カロリー制限 / 放射線 / 消化管腫瘍 / がん予防 / 発がん |
Outline of Final Research Achievements |
It has been known that calorie restriction (CR) extends lifespan and prevents cancer. We previously reported that CR extended lifespan after radiation exposure in mouse model. However, there are few reports on the preventive effects of CR against radiation-associated tumors. Hence, we examined the cancer preventive effects of CR on radiation-induced intestinal tumors using familial adenomatous polyposis mouse model. In this study, we found that juvenile-, young adult- or adult-onset CR inhibited the increase in body weights. CR also inhibited both the total number of tumor and tumor size. Especially, CR suppressed the tumor growth. Juvenile-onset CR was highly effective in reducing the risk for radiation-induced tumorigenesis. Young adult- and adult-onset CR also had the beneficial effect on prevention of radiation-induced tumors.
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Report
(5 results)
Research Products
(82 results)
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[Journal Article] Age Modifies the Effect of 2-MeV Fast Neutrons on Rat Mammary Carcinogenesis2017
Author(s)
Imaoka T, Nishimura M, Daino K, Hosoki A, Takabatake M, Kokubo T, Doi K, Showler K, Nishimura Y, Moriyama H, Morioka T, Shimada Y, Kakinuma S.
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Journal Title
Radiat Res
Volume: 188(4)
Issue: 4
Pages: 419-425
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] Analysis of genes involved in the PI3K/Akt pathway in radiation- and MNU-induced rat mammary carcinomas2016
Author(s)
Kaye Showler , Mayumi Nishimura , Kazuhiro Daino , Tatsuhiko Imaoka , Yukiko Nishimura , Takamitsu Morioka , Benjamin J. Blyth , Toshiaki Kokubo , Masaru Takabatake , Maki Fukuda , Hitomi Moriyama , Shizuko Kakinuma , Masahiro Fukushi , Yoshiya Shimada
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Journal Title
Journal of radiation research
Volume: 58
Issue: 2
Pages: 183-194
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] A Rat Model to Study the Effects of Diet-Induced Obesity on Radiation-Induced Mammary Carcinogenesis2016
Author(s)
12.Imaoka T, Nishimura M, Daino K, Morioka T, Nishimura Y, Uemura H, Akimoto K, Furukawa Y, Fukushi M, Wakabayashi K, Mutoh M, Shimada Y.
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Journal Title
Radiat Res
Volume: 185
Issue: 5
Pages: 505-15
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] Journal of Cancer Prevention2016
Author(s)
谷 修祐 , Blyth Benjamin , 尚 奕 , 森岡 孝満 , 柿沼 志津子 , 島田 義也
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Journal Title
Using a multi-stage carcinogenesis model to investigate calorie restriction as a potential tool for post-irradiation mitigation of cancer risk
Volume: 21
Issue: 2
Pages: 115-120
DOI
Related Report
Peer Reviewed / Int'l Joint Research
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[Journal Article] The effect of age at exposure on the inactivating mechanisms and relative contributions of key tumor suppressor genes in radiation-induced mouse T-cell lymphomas.2015
Author(s)
Sunaoshi M, Amasaki Y, Hirano-Sakairi S, Blyth BJ, Morioka T, Kaminishi M, Shang Y, Nishimura M, Shimada Y, Tachibana A, Kakinuma S.
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Journal Title
Mutat Res
Volume: 779
Pages: 58-67
DOI
Related Report
Peer Reviewed
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[Journal Article] Ionizing radiation, inflammation, and their interactions in colon carcinogenesis in Mlh1-deficient mice2015
Author(s)
Morioka T, Miyoshi-Imamura T, Blyth BJ, Kaminishi M, Kokubo T, Nishimura M, Kito S, Tokairin Y, Tani S, Murakami-Murofushi K, Yoshimi N, Shimada Y, Kakinuma S
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Journal Title
Cancer Sci
Volume: 106(3)
Issue: 3
Pages: 217-226
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Illuminating Radiation Carcinogenesis with the Light of Quantum Technology2017
Author(s)
Tatsuhiko Imaoka, Takamitsu Morioka, Yukiko Nishimura, Mutsumi Kaminishi, Masaru Takabatake, Daisuke Iizuka, Ken-ichi Kudo, Kazuhiro Daino, Mayumi Nishimura, Akinari Yokoya, Koichi Yamakawa, Makoto Aoyama, Hiroyuki Takuwa, Makoto Higuchi, Shizuko Kakinuma
Organizer
1st QST International Symposium
Related Report
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[Presentation] Age-dependent thymus regeneration after irradiation may change the initiating cells for radiation-induced lymphomagenesis2017
Author(s)
Masaaki Sunaoshi, Blyth J. Benjamin, Yi Shang, Chizuru Tsuruoka, Shinobu Sakairi, Takamitsu Morioka, Mayumi Shinagawa, Mari Ogawa, Atsuko Ishikawa, Kazuhiro Daino, Keiji Suzuki, Yoshiya Shimada, Akira Tachibana, Shizuko Kakinuma
Organizer
63rd Annual Radiation Research Society Meeting
Related Report
Int'l Joint Research
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[Presentation] International Dose Effect Alliance Workshop 2016 -Low Dose Research at QST-NIRS-2016
Author(s)
Yutaka Yamada, Shizuko Kakinuma, Tatsuhiko Imaoka, Kazuhiro Daino, Takamitsu Morioka, Mayumi Nishimura, Tetsuo Nakajima, Michiya Sasaki, Hiroshi Takeshita, Takeo Shimomura, Jun Ohtake, Atsuro Ishida, Yoshiya Shimada
Organizer
International Dose Effect Alliance Workshop 2016
Place of Presentation
Electric Power Research Institute, USA
Year and Date
2016-11-09
Related Report
Int'l Joint Research / Invited
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[Presentation] γ線・中性子線誘発ラット乳がんにおけるゲノム変異とサブタイプの解析2016
Author(s)
森山 ひとみ, 臺野 和広, 今岡 達彦, 西村 まゆみ, 西村 由希子, 森岡 孝満, 柿沼 志津子, 井上 一雅, 福士 政広, 島田 義也
Organizer
日本放射線影響学会第59回大会
Place of Presentation
JMSアステールプラザ, 広島
Year and Date
2016-10-26
Related Report
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[Presentation] がん起源細胞と放射線シグネチャ Sstand at the crossroad and look2016
Author(s)
今岡 達彦, 臺野 和広, 鶴岡 千鶴, 高畠 賢, 西村 まゆみ, 西村 由希子, 細木 彩夏, 小川 真里, 山田 裕, 森岡 孝満, 島田 義也, 柿沼 志津子
Organizer
日本放射線影響学会第59回大会
Place of Presentation
JMSアステールプラザ, 広島
Year and Date
2016-10-26
Related Report
Invited
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[Presentation] Genomic alterations and subtypes of rat mammary carcinomas induced by gamma rays or neutrons.2016
Author(s)
Hitomi Moriyama, Kazuhiro Daino, Tatsuhiko Imaoka, Masaru Takabatake, Yukiko Nishimura, Mayumi Nishimura, Takamitsu Morioka, Shizuko Kakinuma, Kazumasa Inoue, Masahiro Fukushi, Yoshiya Shimada.
Organizer
Radiation Research Society 62nd Annual International Meeting
Place of Presentation
Hilton Waikoloa Village, USA
Year and Date
2016-10-16
Related Report
Int'l Joint Research
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[Presentation] 多様な誘発方法でのラット乳がんを用いた免疫染色によるサブタイピング法の検討2016
Author(s)
西村 由希子, 今岡 達彦, 高畠 賢, 臺野 和広, 森岡 孝満, 西村 まゆみ, 横田 拓実, 太田原 雅美, 柿沼 志津子, 島田 義也
Organizer
第25回乳癌基礎研究会
Place of Presentation
市立奈良病院, 奈良
Year and Date
2016-07-23
Related Report
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[Presentation] Genomic alterations in lung cancers in rats exposed to X-rays as neonates, juveniles or adults2015
Author(s)
Yamada Y, Iwata K, Yamazaki S, Morioka T, Daino K, Nishimura M, Kakinuma S, Shimada Y
Organizer
Circulating Biomarkers World Congress 2015
Place of Presentation
Wyndham Hotel, Boston, USA
Year and Date
2015-03-23 – 2015-03-24
Related Report
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[Presentation] Chemoprevention of radiation induced intestinal tumorigenesis by tras-resveratrol in Apc min mice2014
Author(s)
Morioka T, Sunaoshi M, Blyth BJ, Tsuruoka C, Nishimura M, Shang Y, Tani S, Kaminishi M, Imaoka T, Yamada Y, Shimada Y, Kakinuma S
Organizer
放射線防護研究センター(WHO協力)シンポジウム「こどもの放射線被ばくを考える」
Place of Presentation
国立がん研究センター国際研究交流会館
Year and Date
2014-12-07 – 2014-12-09
Related Report
Invited
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[Presentation] Utilising archived tissue from mouse lifespan studies to characterise carbon ion radiotherapy-induced second tumors2014
Author(s)
Blyth BJ, Kakinuma S, Yamada Y, Morioka T, Sakairi S, Amasaki Y, Shang Y, Tsuruoka C, Imaoka T, Nishimura M, Shimada Y
Organizer
60th annual meeting of the radiation research society
Place of Presentation
Red Rock Casino Resort Spa, Las Vegas, NV, USA
Year and Date
2014-09-21 – 2014-09-24
Related Report
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