| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
cDNA display is an in vitro selection method to evolve peptides and proteins, which allow the introductions of non-natural amino acids and chemical modification after translation. This advantage enables a peptide to form a multiple of formation. In this study, we developed two kinds of elemental technologies to diversify peptide formations, 1) introduction of non-natural amino acids, 2) chemical cross-linking of disulfide bonds in a peptide with cross-linking agents. These achievements were published by seven journal papers and three patents.
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