Development of a high efficient screening technique of small molecules binding to a target site of protein

• Project/Area Number: 26350976
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Chemical biology
• Research Institution: Institute of Physical and Chemical Research
• Principal Investigator: Kondoh Yasumitsu 国立研究開発法人理化学研究所, 環境資源科学研究センター, 専任研究員 (80333342)
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: ケミカルアレイ / プロリンリンカー / p38MAPキナーゼ

Outline of Final Research Achievements

Small molecules are important tools to investigate biological system in chemical biology research. A strategy is important for efficient screening of small molecules specifically binding to target protein from chemical library. In this research, I have developed technology to improve detectivity of chemical array and method for efficient screening of small molecules specifically binding to a focused site of target protein using the advanced chemical array.

Research Products

• [Journal Article] Chemical-induced inhibition of blue light-mediated seedling development caused by disruption of upstream signal transduction involving cryptochromes in Arabidopsis thaliana. (2017)
  • Author(s): Ong WD, Okubo-Kurihara E, Kurihara Y, Shimada S, Makita Y, Kawashima M, Honda K, Kondoh Y, Watanabe N, Osada H, Cutler SR, Sudesh K, Matsui M
  • Journal Title: Plant Cell Physiol Volume: 58 Pages: 95-105
  • DOI: 10.1093/pcp/pcw181
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synthesis of Grb2 SH2 domain proteins for mirror-image screening systems. (2017)
  • Author(s): Noguchi T, Ishiba H, Honda K, Kondoh Y, Osada H, Ohno H, Fujii N, Oishi S.
  • Journal Title: Bioconjugate Chemistry Volume: 28 Issue: 2 Pages: 609-619
  • DOI: 10.1021/acs.bioconjchem.6b00692
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Allantopyrone A activates the Keap1-Nrf2 pathway and protects from oxidative stress-induced cell death in PC12 cells (2017)
  • Author(s): Shota Uesugi, Makoto Muroi, Yasumitsu Kondoh, Yoshihito Shiono, Hiroyuki Osada, Ken-ichi Kimura
  • Journal Title: The Journal of Antibiotics Volume: 70 Issue: 4 Pages: 429-434
  • DOI: 10.1038/ja.2016.99
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Inhibition of CRM1-mediated nuclear export of influenza A nucleoprotein and nuclear export protein as a novel target for antiviral drug development. (2017)
  • Author(s): Chutiwitoonchai N, Mano T, Kakisaka M, Sato H, Kondoh Y, Osada H, Kotani O, Yokoyama M, Sato H, Aida Y
  • Journal Title: Virology Volume: 507 Pages: 32-39
  • DOI: 10.1016/j.virol.2017.04.001
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Investigation of the inhibitory mechanism of apomorphine against MDM2-p53 interaction. (2017)
  • Author(s): Ishiba H, Noguchi T, Shu K, Ohno H, Honda K, Kondoh Y, Osada H, Fujii N, Oishi S
  • Journal Title: Bioorg Med Chem Lett Volume: 印刷中 Issue: 11 Pages: 2571-2574
  • DOI: 10.1016/j.bmcl.2017.03.082
  • Peer Reviewed / Open Access
• [Journal Article] Chemical fragment arrays for rapid druggability assessment. (2016)
  • Author(s): Aretz J, Kondoh Y, Honda K, Anumala UR, Nazare M, Watanabe N, Osada H, Rademacher C
  • Journal Title: Chem Comm Volume: 52 Issue: 58 Pages: 9067-9070
  • DOI: 10.1039/c5cc10457b
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Screening of a virtual mirror-image library of natural products (2016)
  • Author(s): T. Noguchi, S. Oishi, K. Honda, Y. Kondoh, T. Saito, H. Ohno, H. Osada, N. Fujii
  • Journal Title: Chem. Comm. Volume: 52 Issue: 49 Pages: 7653-7656
  • DOI: 10.1039/c6cc03114e
  • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
• [Journal Article] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. (2016)
  • Author(s): Kawamura T, Kawatani M, Muroi M, Kondoh Y, Futamura Y, Aono H, Tanaka M, Honda K, Osada H
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 26521-26521
  • DOI: 10.1038/srep26521
  • Peer Reviewed / Open Access
• [Journal Article] Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ. (2016)
  • Author(s): Kondoh Y, Honda K, Hiranuma S, Hayashi T, Shimizu T, Watanabe N, Osada H
  • Journal Title: Sci Rep Volume: 6 Issue: 1 Pages: 29881-29881
  • DOI: 10.1038/srep29881
  • Peer Reviewed / Open Access
• [Journal Article] Opposing roles for SNAP23 in secretion in exocrine and endocrine pancreatic cells (2016)
  • Author(s): Masataka Kunii, et al,
  • Journal Title: J. Cell Biol. Volume: 215 Issue: 1 Pages: 121-138
  • DOI: 10.1083/jcb.201604030
  • Peer Reviewed / Open Access
• [Journal Article] Potential role of the formation of tunneling nanotubes in HIV-1 spread in macrophages. (2016)
  • Author(s): Hashimoto M, Bhuyan F, Hiyoshi M, Noyori O, Nasser H, Miyazaki M, Saito T, Kondoh Y, Osada H, Kimura S, Hase K, Ohno H, Suzu S
  • Journal Title: J Immunol Volume: 196 Issue: 4 Pages: 1832-1841
  • DOI: 10.4049/jimmunol.1500845
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Identification of matrix metalloproteinase inhibitors by chemical arrays. (2015)
  • Author(s): Kawatani M, Fukushima Y, Kondoh Y, Honda K, Sekine T, Yamaguchi Y, Taniguchi N, Osada H
  • Journal Title: Biosci Biotechnol Biochem Volume: 79 Issue: 10 Pages: 1597-1602
  • DOI: 10.1080/09168451.2015.1045829
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] A Novel Antiviral Target Structure Involved in the RNA Binding, Dimerization, and Nuclear Export Functions of the Influenza A Virus Nucleoprotein. (2015)
  • Author(s): Kakisaka M, Sasaki Y, Yamada K, Kondoh Y, Hikono H, Osada H, Tomii K, Saito T, Aida Y
  • Journal Title: PLoS Pathog Volume: 11 Issue: 7 Pages: e1005062-e1005062
  • DOI: 10.1371/journal.ppat.1005062
  • Peer Reviewed / Open Access
• [Journal Article] Novel abscisic acid antagonists identified with chemical array screening. (2015)
  • Author(s): Ito T, Kondoh Y, Yoshida K, Umezawa T, Shimizu T, Shinozaki K, Osada H
  • Journal Title: Chembiochem Volume: 16 Issue: 17 Pages: 2471-2478
  • DOI: 10.1002/cbic.201500429
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Toxic tau oligomer formation blocked by capping of cysteine residues with 1,2-dihydroxybenzene groups. (2015)
  • Author(s): Soeda Y, Yoshikawa M, Almeida OF, Sumioka A, Maeda S, Osada H, Kondoh Y, Saito A, Miyasaka T, Kimura T, Suzuki M, Koyama H, Yoshiike Y, Sugimoto H, Ihara Y, Takashima A
  • Journal Title: Nat Commun Volume: 6 Issue: 1 Pages: 10216-10216
  • DOI: 10.1038/ncomms10216
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synthesis of Vpr-binding derivative for use as a novel HIV-1 inhibitor. (2015)
  • Author(s): Hagiwara K, Ishii H, Murakami T, Takeshima SN, Chutiwitoonchai N, Kodama EN, Kawaji K, Kondoh Y, Honda K, Osada H, Tsunetsugu-Yokota Y, Suzuki M, Aida Y
  • Journal Title: PLoS One Volume: 10 Issue: 12 Pages: e0145573-e0145573
  • DOI: 10.1371/journal.pone.0145573
  • Peer Reviewed / Open Access
• [Journal Article] Construction and application of a photo-cross-linked chemical array. (2015)
  • Author(s): Kondoh Y, Honda K, Osada H
  • Journal Title: Methods Mol Biol 2015;1263:29-41 Volume: 1263 Pages: 29-41
  • DOI: 10.1007/978-1-4939-2269-7_3
  • ISBN: 9781493922680, 9781493922697
  • Peer Reviewed / Open Access
• [Journal Article] A small compound targeting TACC3 revealed its different spatiotemporal contributions for spindle assembly in cancer cells. (2014)
  • Author(s): Yao R, Kondoh Y, Natsume Y, Yamanaka H, Inoue M, Toki H, Takagi R, Shimizu T, Yamori T, Osada H, Noda T
  • Journal Title: Oncogene Volume: in press Issue: 33 Pages: 1-11
  • DOI: 10.1038/onc.2013.382
  • Peer Reviewed / Open Access
• [Journal Article] A small molecule that induces reactive oxygen species via cellular glutathione depletion. (2014)
  • Author(s): Kawamura T, Kondoh Y, Muroi M, Kawatani M, Osada H.
  • Journal Title: Biochem J Volume: 463 Issue: 1 Pages: 53-63
  • DOI: 10.1042/bj20140669
  • Peer Reviewed / Open Access
• [Presentation] 鏡像体タンパク質を利用したc-Src SH2ドメイン阻害剤の探索法の開発 (2017)
  • Author(s): 周敬棠、野口太朗、本田香織、近藤恭光、長田裕之、大野浩章、藤井信孝、大石真也
  • Organizer: 日本薬学会第137年会
  • Place of Presentation: 東北大学、仙台国際センター（宮城県仙台市）
  • Year and Date: 2017-03-25
• [Presentation] 化合物アレイの新たな活用法：天然物の鏡像体化合物群の活用を目指したスクリーニング法の開発 (2017)
  • Author(s): 近藤恭光、野口太朗、大石真也、本田香織、大野浩章、藤井信孝、長田裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-18
• [Presentation] RK460を基盤としたABA受容体選択的アンタゴニストの開発 (2017)
  • Author(s): 由田和津子、三瓶悠、平井剛、伊藤卓也、近藤恭光、清水猛、長澤和夫、袖岡幹子、長田裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-18
• [Presentation] ChemProteoBase を用いたMTH1阻害剤の作用解析 (2017)
  • Author(s): 室井 誠、川谷 誠、河村 達郎、近藤 恭光、二村 友史、田中美帆、青野晴美、本田香織 長田裕之
  • Organizer: 日本農芸化学会2017年度大会
  • Place of Presentation: 京都女子大学（京都府京都市）
  • Year and Date: 2017-03-18
• [Presentation] Improvement of chemical array and comparative chemical array screening of p38γ/δ MAPK inhibitor. (2017)
  • Author(s): Yasumitsu Kondoh, Kaori Honda, Sayoko Hiranuma, Takeshi Shimizu, Tomomi Sekine, Nobumoto Watanabe, Hiroyuki Osada
  • Organizer: The 3rd CSRS-ITbM Joint Workshop
  • Place of Presentation: Noyori Conference Hall, Nagoya University (Nagoya, Aichi)
  • Year and Date: 2017-01-12
• [Presentation] Identification of the molecular targets and electrophilic properties of covalent-binding anti-cancer compounds. (2016)
  • Author(s): Shota Uesugi, Makoto Muroi, Yasumitsu Kondoh, Tetsuro Yamashita, Yoshihito Shiono, Masaru Hashimoto, Hiroyuki Osada, Ken-ichi Kimura
  • Organizer: 1st UGAS, Iwate University International Symposium 2016
  • Place of Presentation: Education and Research Building, Iwate University (Morioka, Iwate)
  • Year and Date: 2016-12-17
  • Int'l Joint Research
• [Presentation] Effect of fluoropyrimidines on aflatoxin production. (2016)
  • Author(s): Toshiyoshi Yamamoto, Takahiro Kagemoto, Kurin Iimura, Yasumitsu Kondoh, Kaori Honda, Hiroyuki Osada, Shohei Sakudai
  • Organizer: International Symposium of Mycotoxicology 2016
  • Place of Presentation: Yayoi Auditorium, The University of Tokyo (Tokyo)
  • Year and Date: 2016-12-01
  • Int'l Joint Research
• [Presentation] Proteomic profiling of small-molecule inhibitors reveals dispensability of MTH1 for cancer cell survival. (2016)
  • Author(s): Tatsuro Kawamura, Makoto Kawatani, Makoto Muroi, Yasumitsu Kondoh, Yushi Futamura, Harumi Aono, Miho Tanaka, Kaori Honda, and Hiroyuki Osada
  • Organizer: 28th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
  • Place of Presentation: ICM Messe Munchen (Munich, Germany)
  • Year and Date: 2016-11-29
  • Int'l Joint Research
• [Presentation] 糸状菌由来の共有結合性抗がん物質による細胞応答と標的分子の比較 (2016)
  • Author(s): 上杉祥太、室井 誠、近藤恭光、山下哲郎、塩野義人、橋本 勝、長田裕之、木村賢一
  • Organizer: 第89回日本生化学会大会
  • Place of Presentation: 東北大学川内北キャンパス（宮城県仙台市）
  • Year and Date: 2016-09-27
• [Presentation] ヒト免疫不全ウイルス1型(HIV-1)Gagと宿主因子TSG101との相互作用を標的とする新規HIV薬の開発 (2016)
  • Author(s): Lowela Siarot、佐藤洋隆、Nopporn Chutiwitoonchai、小谷治、横山勝、佐藤裕徳、本田香織、近藤恭光、長田裕之、間陽子
  • Organizer: 第１59回日本獣医学会学術集会
  • Place of Presentation: 日本大学生物資源科学部湘南キャンパス(神奈川県藤沢市)
  • Year and Date: 2016-09-08
• [Presentation] Comparative chemical array screening of p38γ/δ MAPK inhibitors by focusing on a single gatekeeper residue difference between p38α/β and p38γ/δ. (2016)
  • Author(s): Yasumitsu Kondoh, Kaori Honda, Sayoko Hiranuma, Takeshi Shimizu, Hiroyuki Osada
  • Organizer: １7th Tetrahedron Symposium
  • Place of Presentation: MeliaSitges Hotel Congress Centre (Sitges, Spain)
  • Year and Date: 2016-06-30
  • Int'l Joint Research
• [Presentation] The Unusual Suspects: Fragment Screening of Carbohydrate-binding Proteins. (2016)
  • Author(s): Jonas Aretz, Upendra Rao Anumala, Paul Robin Wratil, Hannes Baukmann, Eike-Christian Wamhoff, Jonas Hanske, Hoang Giang Nguyen, Yasumitsu Kondoh, Kaori Honda, Nobumoto Watanabe, Hiroyuki Osada, Werner Reutter, Marc Nazae, Christoph Rademacher.
  • Organizer: 10th Drug Design & Medicinal Chemistry
  • Place of Presentation: Maritim Hotel Berlin (Berlin, Germany)
  • Year and Date: 2016-05-11
  • Int'l Joint Research
• [Presentation] Identification of MTH1 inhibitors by chemical arrays. (2016)
  • Author(s): Tatsuro Kawamura, Makoto Kawatani, Yasumitsu Kondoh, Makoto Muroi, Yushi Futamura, Harumi Aono, Miho Tanaka, Kaori Honda, Hiroyuki Osada
  • Organizer: RIKEN-Max Planck Joint Research Center Fifth Annual Symposium
  • Place of Presentation: Harnack-Haus, Tagungshotel der Max-Planck-Gesellschaft (Berlin, Germany)
  • Year and Date: 2016-04-18
  • Int'l Joint Research
• [Presentation] Comparative chemical array screening for p38γ/δ MAPK inhibitors using a single gatekeeper residue difference between p38α/β and p38γ/δ. (2016)
  • Author(s): Yasumitsu Kondoh, Kaori Honda, Sayoko Hiranuma, Takeshi Shimizu, Hiroyuki Osada
  • Organizer: RIKEN-Max Planck Joint Research Center Fifth Annual Symposium
  • Place of Presentation: Harnack-Haus, Tagungshotel der Max-Planck-Gesellschaft (Berlin, Germany)
  • Year and Date: 2016-04-18
  • Int'l Joint Research
• [Presentation] Fragment arrays for early druggability assessments. (2016)
  • Author(s): Jonas Aretz, Yasumitsu Kondoh, Kaori Honda, Upendra Rao Anumala, Marc Nazare, Nobumoto Watanabe, Hiroyuki Osada, Christoph Rademacher
  • Organizer: RIKEN-Max Planck Joint Research Center Fifth Annual Symposium
  • Place of Presentation: Harnack-Haus, Tagungshotel der Max-Planck-Gesellschaft (Berlin, Germany)
  • Year and Date: 2016-04-18
  • Int'l Joint Research
• [Presentation] Chemical array screening of matrix metalloproteinase inhibitors. (2016)
  • Author(s): Yasumitsu Kondoh, Makoto Kawatani, Kaori Honda, Tomomi Sekine, Hiroyuki Osada
  • Organizer: 日本農芸化学会2016年度大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-27
• [Presentation] 化合物アレイを用いたアフラトキシン生産阻害物質の探索(その1)－LaeA 結合物質の探索－ (2016)
  • Author(s): 山本利義、影本貴大、飯村九林、髙城景子、近藤恭光、本田香織、長田裕之、作田庄平
  • Organizer: 日本農芸化学会2016年度大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-27
• [Presentation] 化合物アレイを用いたアフラトキシン生産阻害物質の探索（その2）－PacC 結合物質の探索－ (2016)
  • Author(s): 影本貴大、山本利義、飯村九林、髙城景子、近藤恭光、本田香織、長田裕之、作田庄平
  • Organizer: 日本農芸化学会2016年度大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-27
• [Presentation] BCR-ABLの蛋白質分解誘導剤開発を指向したBCR-ABL結合化合物の探索 (2016)
  • Author(s): 柴田識人、大岡伸通、服部隆行、橋井則貴、斎藤臣雄、近藤恭光、石井明子、長田裕之、内藤幹彦
  • Organizer: 日本薬学会第136年会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-03-26
• [Presentation] サリチル酸情報伝達系を標的とする低分子阻害剤の同定とその作用機作の解析 (2016)
  • Author(s): 石濱伸明、能年義輝、崔 勝媛、Ivana Saska1、野村有子、中神弘史、近藤恭光、長田裕之、白須 賢
  • Organizer: 平成28年度日本植物病理学会大会
  • Place of Presentation: 岡山コンベンションセンター（岡山県岡山市）
  • Year and Date: 2016-03-21
• [Presentation] Identification of SA-signaling inhibitors and their target protein in Arabidopsis. (2016)
  • Author(s): Seung-won Choi, Nobuaki Ishihama, Yoshiteru Noutoshi, Ivana Saska, Yuko Nomura, Hirofumi Nakagami, Yasumitsu Kondoh, Hiroyuki Osada, Ken Shirasu
  • Organizer: 第57回日本植物生理学会年会
  • Place of Presentation: 岩手大学上田キャンパス（岩手県盛岡市）
  • Year and Date: 2016-03-18
• [Presentation] Identification and characterization of small-molecule inhibitors to plant immune responses. (2016)
  • Author(s): Ishihama N, Noutoshi Y, Choi S, Saska I, Nomura Y, Nakagami H, Kondoh Y, Osada H, Shirasu K
  • Organizer: 第57回日本植物生理学会年会
  • Place of Presentation: 岩手大学上田キャンパス（岩手県盛岡市）
  • Year and Date: 2016-03-18
• [Presentation] 化合物アレイを用いたアフラトキシン生産阻害物質の探索－AflR結合物質の探索－ (2016)
  • Author(s): 影本貴大、山本利義、飯村九林、髙城景子、近藤恭光、本田香織、長田裕之、作田庄平
  • Organizer: 日本マイコトキシン学会第78回学術講演会
  • Place of Presentation: 川崎生命科学環境研究センター（神奈川県川崎市）
  • Year and Date: 2016-01-08
• [Presentation] Novel screening approach for drug discovery from virtual mirror-image library of natural products. (2015)
  • Author(s): Taro Noguchi, Shinya Oishi, Kaori Honda, Yasumitsu Kondoh, Tamio Saito, Hiroaki Ohno, Hiroyuki Osada, Nobutaka Fujii
  • Organizer: Pacifichem2015
  • Place of Presentation: Hawaii Convention Center (Hawaii, USA)
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Study on biological activities and molecular targets of allantopyrone A and pyrrocidine A isolated from endophytic fungi. (2015)
  • Author(s): Shota Uesugi, Makoto Muroi, Yasumitsu Kondoh, Yoshihito Shiono, Hiroyuki Osada, Ken-ichi Kimura
  • Organizer: Pacifichem2015
  • Place of Presentation: Hawaii Convention Center (Hawaii, USA)
  • Year and Date: 2015-12-15
  • Int'l Joint Research
• [Presentation] Allantopyrone AによるKeap1-Nrf2経路の活性化と細胞保護作用 (2015)
  • Author(s): 上杉祥太、近藤恭光、室井 誠、塩野義人、長田裕之、木村賢一
  • Organizer: 第88回日本生化学会大会
  • Place of Presentation: 神戸ポートアイランド（兵庫県神戸市）
  • Year and Date: 2015-12-01
• [Presentation] Identification of SA-signaling inhibitors and their target protein in Arabidopsis. (2015)
  • Author(s): S.-w. Choi, N. Ishihama, Y. Noutoshi, I. Saska, Y. Nomura, H. Nakagami, Y. Kondoh, H. Osada, K. Shirasu
  • Organizer: 36th New Phytologist Symposium
  • Place of Presentation: Eden Hotel Wolff (Munich, Germany)
  • Year and Date: 2015-11-29
  • Int'l Joint Research
• [Presentation] Investigation of inhibitory mechanism of apomorphine against MDM2–p53 Interaction. (2015)
  • Author(s): Hiroyuki Ishiba, Shinya Oishi, Taro Noguchi, Keito Shu, Hiroaki Ohno, Kaori Honda, Yasumitsu Kondoh, Tamio Saito, Hiroyuki Osada, Nobutaka Fujii
  • Organizer: 第52回ペプチド討論会
  • Place of Presentation: 平塚中央公民館（神奈川県平塚市）
  • Year and Date: 2015-11-16
• [Presentation] Screening and target identification of bio-active compounds in NPDepo. (2015)
  • Author(s): Yasumitsu Kondoh
  • Organizer: NEA & ASIAHORCs Joint Symposium on Chemical Biology
  • Place of Presentation: Okinawa Institute of Science and Technology Graduate University (Okinawa, Japan)
  • Year and Date: 2015-11-09
  • Int'l Joint Research / Invited
• [Presentation] Chemical array screen identifies a novel MMP inhibitor NPDK-18 that suppresses tumor cell migration. (2015)
  • Author(s): Makoto Kawatani, Yasumitsu Kondoh, Kaori Honda, Tomomi Sekine, Hiroyuki Osada
  • Organizer: AACR-NCI-EORTC International Conference on Molecular Targets and Cancer Therapeutics
  • Place of Presentation: Hynes Convention Center (Boston, Massachusetts, USA)
  • Year and Date: 2015-11-05
  • Int'l Joint Research
• [Presentation] Chemical array for screening of inhibitors. (2015)
  • Author(s): Yasumitsu Kondoh
  • Organizer: RIKEN-Academia Sinica Joint Conference on Chemical Biology
  • Place of Presentation: Genomics Research Center, Academia Sinica (Taipei, Taiwan)
  • Year and Date: 2015-10-15
  • Int'l Joint Research / Invited
• [Presentation] Identification of NTCP-targeting small molecules that inhibit HBV entry by cell-based and in vitro technologies. (2015)
  • Author(s): Watashi K, Tsukuda S, Shimura S, Kaneko M, Sluder A, Peel M, Kamisuki S, Matsunaga S, Morishita R, Futamura Y, Kondoh Y, Suzuki R, Aizaki H, Sugiyama M, Borroto-Esoda K, Ryo A, Sugawara F, Osada H, Tanaka Y, Mizokami M, Wakita T
  • Organizer: 2015 International Meeting on Molecular Biology of Hepatitis B Viruses
  • Place of Presentation: Dolce Bad Nauheim (Germany)
  • Year and Date: 2015-10-04
  • Int'l Joint Research
• [Presentation] 植物免疫応答を標的とする低分子阻害剤の同定とその作用機作の解析 (2015)
  • Author(s): 石濱伸明、能年義輝、崔 勝媛、Ivana Saska、野村有子、中神弘史、近藤恭光、長田裕之、白須 賢
  • Organizer: 平成27年度日本植物病理学会関東部会
  • Place of Presentation: 宇都宮大学峰キャンパス（栃木県宇都宮市）
  • Year and Date: 2015-09-10
• [Presentation] 植物免疫反応を阻害する低分子化合物の同定とその標的因子の探索 (2015)
  • Author(s): 崔勝媛、石濱伸明、能年義輝、 Saska Ivana、野村有子、中神弘史、近藤恭光、長田裕之、白須 賢
  • Organizer: 日本植物学会第79回大会
  • Place of Presentation: 朱鷺メッセ新潟コンベンションセンター（新潟県新潟市）
  • Year and Date: 2015-09-06
• [Presentation] サリチル酸に依存した情報伝達を標的とする低分子阻害剤の同定 (2015)
  • Author(s): 石濱伸明、能年義輝、崔勝媛、Ivana Saska、野村有子、中神弘史、近藤恭光、長田裕之、白須 賢
  • Organizer: 平成27年度植物感染生理談話会
  • Place of Presentation: 道後温泉メルバルク松山（愛媛県松山市）
  • Year and Date: 2015-08-24
• [Presentation] MDM2-p53阻害活性を有するアポモルヒネの作用メカニズムの解明 (2015)
  • Author(s): 石場勲之、大石真也、野口太朗、周敬棠、大野浩章、藤井信孝、本田香織、近藤恭光、斎藤臣雄、長田裕之
  • Organizer: 創薬懇話会2015 in 徳島
  • Place of Presentation: グランドエクシブ鳴門ザ・ロッジ（徳島県鳴門市）
  • Year and Date: 2015-07-02
• [Presentation] 天然物とその誘導体の鏡像体化合物群の活用を目指した新規スクリーニング法の開発 (2015)
  • Author(s): 野口太朗、大石真也、本田香織、近藤恭光、斎藤臣雄、大野浩章、長田裕之、藤井信孝
  • Organizer: 日本ケミカルバイオロジー学会 第10回年会
  • Place of Presentation: 東北大学川内キャンパス（宮城県仙台市）
  • Year and Date: 2015-06-10
• [Presentation] Chemical array for screening of bio-active compounds. (2015)
  • Author(s): Yasumitsu Kondoh, Kaori Honda, Tomomi Sekine, Nobumoto Watanabe, Hiroyuki Osada
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The Fourth Symposium
  • Place of Presentation: Kobe Port Island Center (Kobe, Japan)
  • Year and Date: 2015-05-11
  • Int'l Joint Research
• [Presentation] A small molecule that induces reactive oxygen species via cellular glutathione depletion. (2015)
  • Author(s): Tatsuro Kawamura, Yasumitsu Kondoh, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The Fourth Symposium
  • Place of Presentation: Kobe Port Island Center (Kobe, Japan)
  • Year and Date: 2015-05-11
  • Int'l Joint Research
• [Presentation] Identification of matrix metalloproteinase inhibitors by chemical arrays. (2015)
  • Author(s): Makoto Kawatani, Yasumitsu Kondoh, Kaori Honda, Tomomi Sekine, Yoshiki Yamaguchi, Naoyuki Taniguchi, Hiroyuki Osada
  • Organizer: RIKEN-Max Planck Joint Research Center for Systems Chemical Biology The Fourth Symposium
  • Place of Presentation: Kobe Port Island Center (Kobe, Japan)
  • Year and Date: 2015-05-11
  • Int'l Joint Research
• [Presentation] サリチル酸に依存した免疫応答を阻害する低分子化合物の同定 (2015)
  • Author(s): 石濱伸明、能年義輝、崔 勝媛、Ivana Saska、野村有子、中神弘史、村山和隆、白水美香子、近藤恭光、長田裕之、白須 賢
  • Organizer: 平成27年度日本植物病理学会大会
  • Place of Presentation: 明治大学駿河台キャンパス（東京）
  • Year and Date: 2015-03-28 – 2015-03-31
• [Presentation] 化合物アレイによるソニックヘッジホッグ(Shh)結合化合物の探索とそれらとShhとの相互作用の解析 (2015)
  • Author(s): 近藤恭光、河村達郎、本田香織、関根朋美、長田裕之
  • Organizer: 日本農芸化学会2015年度大会
  • Place of Presentation: 岡山大学津島キャンパス（岡山県岡山市）
  • Year and Date: 2015-03-26 – 2015-03-29
• [Presentation] 天然物の鏡像体化合物群の活用を目指した新規スクリーニング法の開発 (2015)
  • Author(s): 野口太朗、大石真也、本田香織、近藤恭光、斎藤臣雄、大野浩章、長田裕之、藤井信孝
  • Organizer: 日本薬学会第135年会
  • Place of Presentation: 神戸サンバーホール、デザイン・クリエイティブセンター神戸（兵庫県神戸市）
  • Year and Date: 2015-03-25 – 2015-03-28
• [Presentation] A small chemical compound, P7 inhibits the salicylic acid signaling pathway in Arabidopsis (2015)
  • Author(s): Seung-won Choi, Nobuaki Ishihama, Yoshiteru Noutoshi, Ivana Saska, Yuko Nomura, Hirofumi Nakagami, Yasumitsu Kondoh, Hiroyuki Osada, Ken Shirasu
  • Organizer: 第56回日本植物生理学会年会
  • Place of Presentation: 東京農業大学世田谷キャンパス（東京）
  • Year and Date: 2015-03-16 – 2015-03-18
• [Presentation] Identification of low-molecular inhibitors for salicylic acid signaling pathway by a high-throughput chemical screening (2015)
  • Author(s): Nobuaki Ishihama, Yoshiteru Noutoshi, Seung-won Choi, Ivana Saska, Yuko Nomura, Hirofumi Nakagami, Kazutaka Murayama, Mikako Shirouzu, Yasumitsu Kondoh, Hiroyuki Osada, Ken Shirasu
  • Organizer: 第56回日本植物生理学会年会
  • Place of Presentation: 東京農業大学世田谷キャンパス（東京）
  • Year and Date: 2015-03-16 – 2015-03-18
• [Presentation] RhoGEF Ect2/極性制御因子Par6複合体による発がんシグナルを阻害する薬剤の探索：(1) Ect2及びPar6-PDZドメイン結合化合物の解析 (2014)
  • Author(s): 田中 弦太郎、冨樫 英人、三浦 悠太、東 覚、近藤 恭光、長田 裕之、三木 徹
  • Organizer: 第37回日本分子生物学会年会(2014年11月25-27日、横浜、パシフィコ横浜)
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-11-25 – 2014-11-27
• [Presentation] NPD926, a small molecule inducer of reactive oxygen species, killcancer cells via glutathione depletion (2014)
  • Author(s): Tatsuro Kawamura, Yasumitsu Kondoh, Makoto Muroi, Makoto Kawatani, Hiroyuki Osada
  • Organizer: 26th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics
  • Place of Presentation: Barcelona, Spain
  • Year and Date: 2014-11-18 – 2014-11-21
• [Presentation] アクセサリータンパク質Vprの核移行を標的にしたマクロファージに対する新規HIV-1阻害剤の最適化研究 (2014)
  • Author(s): 萩原恭二､村上知行、石井英樹、竹嶋伸之輔､ 近藤恭光、本田香織、長田裕之、横田恭子、鈴木正昭、間陽子
  • Organizer: 第62回日本ウイルス学会学術集会
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2014-11-10 – 2014-11-12
• [Presentation] インフルエンザウイルスヌクレオプロテイン(NP)を標的とした新規創薬ターゲットの同定 (2014)
  • Author(s): 柿坂 道範、佐々木裕、Nopporn Chutiwitoonchai 、山田 和範 、本田 香織、近藤 恭光、長田 裕之、彦野 弘一、西藤 岳彦、間 陽子
  • Organizer: 第157回日本獣医学会学術集会
  • Place of Presentation: 北海道大学高等教育推進機構（北海道札幌市）
  • Year and Date: 2014-09-09 – 2014-09-12