| Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2015: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Outline of Final Research Achievements |
The aim of this study was to examine the role of CA2 neurons in memory and social behavior. The function of the hippocampal CA2 region remains largely unknown. To control neural activity by using CA2 neuron-selective gene-targeting system, we made several knock-in lines, in which Cre recombinase or tetracycline transactivator was inserted into the translational initiation site of the targeted genes (Rgs14, Amigo2, Abat and so on) in frame. Additionally, we made a new line expressing tdTomato reporter under control of Cre recombinase. The mutant lines developed in this study could be useful tools for analysis of higher brain functions.
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