A role of astrocyte in neuro-glio-vascular unit concerning cerebral microcirculation

• Project/Area Number: 26350981
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Basic / Social brain science
• Research Institution: Keio University
• Principal Investigator: Unekawa Miyuki 慶應義塾大学, 医学部(信濃町), 特任講師 (10548481)
• Co-Investigator(Kenkyū-buntansha): 冨田 裕 慶應義塾大学, 医学部(信濃町), 講師(非常勤) (60276251)
• Co-Investigator(Renkei-kenkyūsha): TANAKA Kenji 慶應義塾大学, 医学部, 准教授 (30329700) ; MASAMOTO Kazuto 電気通信大学, 情報理工学部, 教授 (60455384)
• Research Collaborator: SUZUKI Norihiro ; KANNO Iwao ; WATANABE Tatsushi ; HATAKEYAMA Nao
• Project Period (FY): 2014-04-01 – 2018-03-31
• Project Status: Completed (Fiscal Year 2017)
• Budget Amount: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000); Fiscal Year 2017: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2016: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: 光遺伝学 / 脳微小循環 / アストロサイト / ニューロン / neurovascular unit / 大脳皮質性拡延性抑制 / 脳梗塞 / Na-K-pump / アストログリア / 赤血球速度 / グリア細胞 / neurovasucular unit

Outline of Final Research Achievements

Photostimulation to transgenic mice expressing light-sensitive cation channel, channelrhodopsin-2, in astrocyte or neuron elicited intensity-dependent increase in cortical blood flow. Pharmacological study exhibited specific mechanism of astrocyte- or neuron-originated microcirculatory control.
Cortical spreading depression (CSD) involving mass depolarization of neuron and astrocyte elicited transient constriction and dilation of pial and intraparenchymal penetrating artery, followed by mild constriction, and deceleration of red blood cell (RBC) flowing in capillary in parallel with arterial constriction. Repeated CSD elicited marked dilation of penetrating artery and acceleration of RBC. Spontaneous occurrence of CSD during transient middle cerebral artery occlusion by modified Tamura's method may be involved in formation and/or development of infarction. Susceptibility to CSD was enhanced and recovery from CSD was elongated in familial hemiplegic migraine 2 model mice.

Research Products

• [Journal Article] Enhanced susceptibility to cortical spreading depression in two types of Na+, K+-ATPase α2 subunit-deficient mice as a model of familial hemiplegic migraine 2. (2018)
  • Author(s): Unekawa, M. Ikeda, K., Tomita, Y., Kawakami, K. and Suzuki, N.
  • Journal Title: Cephalalgia Volume: 38 Issue: 9 Pages: 1515-1524
  • DOI: 10.1177/0333102417738249
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Tomita-Seylaz法による慢性頭窓作製後のマウス大脳皮質ミクログリアの長期反復in vivoリアルタイム解析 (2017)
  • Author(s): 結城浩弥, 正本和人, 畝川美悠紀, 冨田裕, 菅野巖, 鈴木則宏
  • Journal Title: 脳循環代謝 Volume: 28 Pages: 249-256
  • NAID: 130006008228
  • Peer Reviewed
• [Journal Article] Dynamic diameter response of intraparenchymal penetrating arteries during cortical spreading depression and elimination of vasoreactivity to hypercapnia in anesthetized mice. (2017)
  • Author(s): Unekawa M, Tomita Y, Masamoto K, Toriumi H, Osada T, Kanno I, Suzuki N
  • Journal Title: J Cereb Blood Flow Metab Volume: 37 Issue: 2 Pages: 657-670
  • DOI: 10.1177/0271678x16636396
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] High-mobility group box 1 is an important mediator of microglial activation induced by cortical spreading depression. (2017)
  • Author(s): Takizawa T., Shibata M., Kayama Y., Shimizu T., Toriumi H., Ebine T., Unekawa M., Koh A., Yoshimura A., Suzuki N.
  • Journal Title: J. Cereb. Blood Flow Metab. Volume: 37 Issue: 3 Pages: 890-901
  • DOI: 10.1177/0271678x16647398
  • Peer Reviewed
• [Journal Article] Dynamic flow velocity mapping from fluorescent dye transit times in the brain surface microcirculation of anesthetized rats and mice. (2016)
  • Author(s): Hoshikawa R, Kawaguchi H, Takuwa H, Ikoma Y, Tomita Y, Unekawa M, Suzuki N, Kanno I, Masamoto K.
  • Journal Title: Microcirculation Volume: 26 Issue: 6 Pages: 416-425
  • DOI: 10.1111/micc.12285
  • Peer Reviewed
• [Journal Article] Alterations in the threshold of the potassium concentration to evokecortical spreading depression during the natural estrous cycle in mice (2016)
  • Author(s): Taeko Ebine, Haruki Toriumi, Toshihiko Shimizu, Miyuki Unekawa, Tsubasa Takizawa, Yohei Kayama, Mamoru Shibata, Norihiro Suzuki
  • Journal Title: Neuroscience Research Volume: 112 Pages: 57-62
  • DOI: 10.1016/j.neures.2016.06.001
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Unveiling astrocytic control of cerebral blood flow with optogenetics (2015)
  • Author(s): Masamoto K, Unekawa M, Watanabe T, Toriumi H, Takuwa H, Kawaguchi H, Kanno I, Matsui K, Tanaka K F, Tomita Y, Suzuki N
  • Journal Title: Scientific reports Volume: 5 Issue: 1 Pages: 11455-11455
  • DOI: 10.1038/srep11455
  • Peer Reviewed / Open Access
• [Journal Article] アストロサイトによる脳血流調節 (2015)
  • Author(s): 正本和人, 畝川美悠紀, 冨田裕, 菅野巌, 鈴木則宏
  • Journal Title: 分子精神医学 Volume: 16 Pages: 17-24
• [Journal Article] Hyperperfusion counteracted by transient rapid vasoconstriction followed by long-lasting oligemia induced by cortical spreading depression in anesthetized mice. (2015)
  • Author(s): Unekawa M, Tomita Y, Toriumi H, Osada T, Masamoto K, Kawaguchi H, Itoh Y, Kanno I, Suzuki N.
  • Journal Title: J Cereb Blood Flow Metab Volume: 35 Issue: 4 Pages: 689-698
  • DOI: 10.1038/jcbfm.2014.250
  • Peer Reviewed / Open Access
• [Journal Article] In vivo imaging of the mouse neurovascular unit under chronic cerebral hypoperfusion. (2014)
  • Author(s): Yata K, Nishimura Y, Unekawa M, Tomita Y, Suzuki N, Tanaka T, Mizoguchi A, Tomimoto H.
  • Journal Title: Stroke. Volume: 45 Issue: 12 Pages: 3698-3703
  • DOI: 10.1161/strokeaha.114.005891
  • Peer Reviewed / Open Access
• [Journal Article] Impairment of CO2 reactivity in RBC velocity and CBF after cortical spreading depression in anesthetized mice (2014)
  • Author(s): Unekawa M, Tomita Y, Toriumi H, Osada T, Masamoto K, Kawaguchi H, Itoh Y, Kanno I, Suzuki N
  • Journal Title: Microvasc. Rev. Commun Volume: 7
  • NAID: 130004678489
  • Peer Reviewed
• [Journal Article] 34. Microvascular sprouting, extension, and creation of new capillary connection with adaptation of the neighboring astrocytes in adult mouse cortex under chronic hypoxia (2014)
  • Author(s): Masamoto K, Takuwa H, Seki C, Taniguchi J, Itoh Y, Tomita Y, Toriumi H, Unekawa M, Kawaguchi H, Ito H, Suzuki N, Kanno I
  • Journal Title: J Cereb Blood Flow Metab Volume: 34 Issue: 2 Pages: 325-31
  • DOI: 10.1038/jcbfm.2013.201
  • Peer Reviewed / Open Access
• [Journal Article] Cellular origin and regulation of D- and L-serine in vitro and in vivo models of cerebral ischemia. (2014)
  • Author(s): Abe T, Suzuki M, Sasabe J, Takahashi S, Unekawa M, Mashima K, Iizumi T, Hamase K, Konno R, Aiso S, Suzuki N.
  • Journal Title: J Cereb Blood Flow Metab Volume: 34(12) Issue: 12 Pages: 1928-1935
  • DOI: 10.1038/jcbfm.2014.164
  • Peer Reviewed / Open Access
• [Presentation] 大脳皮質拡延性抑制／脱分極が結ぶ片頭痛と脳卒中 (2018)
  • Author(s): 畝川美悠紀, 冨田裕, 鈴木則宏.
  • Organizer: 第43回日本脳卒中学会学術集会
  • Invited
• [Presentation] Effect of spreading depolarization on cerebral blood flow and development of infarction under experimental ischemia in anesthetized mice. (2017)
  • Author(s): Unekawa M., Tomita Y., Toriumi H., Osada T., Masamoto K., Kanno I., Suzuki N.
  • Organizer: 28th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2017-04-01
  • Int'l Joint Research
• [Presentation] Spatiotemporal changes in cerebral blood flow induced by transcranial photostimulation to cortical neurons or astrocytes in the transgenic mice expressing channelrhodopsin-2. (2017)
  • Author(s): Hatakeyama N., Masamoto K., Unekawa M., Takuwa H., Kanno I., Matsui K., Tanaka K. F., Tomita Y., Suzuki N.
  • Organizer: 28th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2017-04-01
  • Int'l Joint Research
• [Presentation] Repeated longitudinal in vivo imaging of cortical microglia under chronic hypoxia in the mice using twophoton microscopy with a closed cranial window technique. (2017)
  • Author(s): Kanno I., Masamoto K., Yuki H., Sugashi T., Unekawa M., Tomita Y., Suzuki N.
  • Organizer: 28th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: ベルリン(ドイツ)
  • Year and Date: 2017-04-01
  • Int'l Joint Research
• [Presentation] Longitudinal two-photon imaging of microvascular remodeling and microglial response to chronic hypoxia in in vivo mouse cortex. (2017)
  • Author(s): Yuki T., Masamoto K., Unekawa M., Sugashi T., Tomita Y., Kanno I., Suzuki N.
  • Organizer: 第42回日本微小循環学会総会
  • Place of Presentation: 富山国際会議場(富山県富山市)
  • Year and Date: 2017-03-25
• [Presentation] 中大脳動脈閉塞時に発生する拡延性脱分極が脳血流と梗塞形成に及ぼす影響 (2017)
  • Author(s): 畝川美悠紀, 冨田裕, 鳥海春樹, 長田高志, 正本和人, 菅野巖, 鈴木則宏.
  • Organizer: 第42回日本脳卒中学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪市北区)
  • Year and Date: 2017-03-16
• [Presentation] 神経賦活とグリア賦活による脳血流反応の比較：オプトジェネティクスによる検討 (2017)
  • Author(s): 畠山菜緒, 正本和人, 畝川美悠紀, 田桑弘之, 菅野巖, 松井広, 田中謙二, 冨田裕, 鈴木則宏.
  • Organizer: 第42回日本脳卒中学会学術集会
  • Place of Presentation: 大阪国際会議場(大阪市北区)
  • Year and Date: 2017-03-16
• [Presentation] 脳虚血後のグリア細胞の形状変化におけるin vivo長期解析 (2017)
  • Author(s): 渡部真子, 須貸拓馬, 蜂谷亮太, 安部貴人, 畝川美悠紀, 鳥海春樹, 冨田裕, 鈴木則宏, 田桑弘之, 菅野巖, 正本和人
  • Organizer: 日本機械学会 第30 回バイオエンジニアリング講演会
• [Presentation] 低酸素誘発性脳微小血管リモデリングにおけるミクログリアの関与 (2017)
  • Author(s): 曽我直人, 結城浩弥, 須貸拓馬, 畝川美悠紀, 冨田裕, 菅野巖, 鈴木則宏, 正本和人
  • Organizer: 酸素ダイナミクス研究会
• [Presentation] Na+,K+-ATPase α2サブユニット遺伝子欠損マウスにおける皮質拡延性抑制に対する感受性と脳内c-Fos発現分布 (2017)
  • Author(s): 畝川美悠紀, 池田啓子, 冨田裕, 川上潔, 鈴木則宏
  • Organizer: 第60回日本脳循環代謝学会学術集会
• [Presentation] Widespread c-Fos expression after cortical spreading depression; possible differences between two types of animal models of familial hemiplegic migraine 2 (2017)
  • Author(s): Unekawa M., Ikeda K., Tomita Y., Kawakami K., Suzuki N.
  • Organizer: The XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] Enhanced susceptibility to cortical spreading depression and different degree in two-types of Na+,K+-ATPase a2 subunit-deficient mice as a model of familial hemiplegic migraine 2. (2017)
  • Author(s): Unekawa M., Ikeda K., Tomita Y., Kawakami K., Suzuki N.
  • Organizer: 18th Congress of the International Headache Society
  • Int'l Joint Research
• [Presentation] Neuroprotective effects of dimethyl fumarate on cerebral ischemia-reperfusion injury in mice (2017)
  • Author(s): Minami K., Abe T., Tsukada N., Unekawa M., Takahashi S., Suzuki N.
  • Organizer: The 8th Korea-Japan Joint Stroke Conference
  • Int'l Joint Research
• [Presentation] Hemodynamic response to optogenetic activation of ChR2-expressing neurons or astrocytes in the mouse cortex (2017)
  • Author(s): Hatakeyama N., Masamoto K., Unekawa M., Takuwa H., Kanno I., Matsui K., Tanaka K. F., Tomita Y., Suzuki N.
  • Organizer: 第9回光操作研究会
• [Presentation] Cerebral blood flow responses to photostimulation in the transgenic miceexpressing channelrhodopsin-2 in the cortical neurons or astrocytes. (2017)
  • Author(s): Hatakeyama N., Masamoto K., Unekawa M., Takuwa H., Kanno I., Matsui K., Tanaka K., Tomita Y., Suzuki N.
  • Organizer: The XXIII World Congress of Neurology
  • Int'l Joint Research
• [Presentation] 一時的脳虚血時に発生する拡延性脱分極に伴う血流変化と梗塞形成に対する影響 (2016)
  • Author(s): 畝川美悠紀, 冨田裕, 鳥海春樹, 長田高志, 正本和人, 菅野巖, 鈴木則宏
  • Organizer: 第59回日本脳循環代謝学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2016-11-11
• [Presentation] Tomita-Seylaz法による慢性頭窓作成後のマウス大脳皮質ミクログリアのin vivo長期反復解析. (2016)
  • Author(s): 結城浩弥, 正本和人, 畝川美悠紀, 冨田裕, 菅野巖, 鈴木則宏.
  • Organizer: 第59回日本脳循環代謝学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2016-11-11
• [Presentation] オプトジェネティクスを用いたアストロサイト・ニューロン賦活による脳血流空間伝播の比較 (2016)
  • Author(s): 畠山菜緒, 正本和人, 畝川美悠紀, 田桑弘之, 菅野巖, 松井広, 田中謙二, 冨田裕, 鈴木則宏
  • Organizer: 第59回日本脳循環代謝学会学術集会
  • Place of Presentation: あわぎんホール(徳島県徳島市)
  • Year and Date: 2016-11-11
• [Presentation] Heterogeneous response of microcirculation to spreading depolarization evoked during middle cerebral artery occlusion in anesthetized mice. (2016)
  • Author(s): Unekawa M., Tomita Y., Toriumi H., Osada T., Masamoto K., Kanno I., Suzuki N.
  • Organizer: 第41回日本微小循環学会総会
  • Place of Presentation: コクヨホール(東京都港区)
  • Year and Date: 2016-09-23
• [Presentation] Dynamic flow velocity mapping based on transient time measurements of fluorescent dye. (2016)
  • Author(s): Hoshikawa R., Kawaguchi H., Takuwa H., Ikoma Y., Tomita Y., Unekawa M., Suzuki N., Kanno I., Masamoto K.
  • Organizer: 第41回日本微小循環学会総会
  • Place of Presentation: コクヨホール(東京都港区)
  • Year and Date: 2016-09-23
• [Presentation] Acceleration of red blood cells in intraparenchymal capillaries and dilation of arterial diameter in response to hypercapnia were diminished after passage of cortical spreading depression in anesthetized mice. (2016)
  • Author(s): Tomita Y., Unekawa M., Toriumi H., Osada T., Masamoto K., Kawaguchi H., Itoh Y., Kanno I., Suzuki N.
  • Organizer: 第41回日本微小循環学会総会
  • Place of Presentation: コクヨホール(東京都港区)
  • Year and Date: 2016-09-23
• [Presentation] Response of cerebral blood flow to optogenetic photostimulation of cortical neurons and astrocytes (2016)
  • Author(s): 冨田裕, 渡部竜志, 正本和人, 畝川美悠紀, 鳥海春樹, 田桑弘之, 菅野巌, 松井広, 田中謙二, 鈴木則宏.
  • Organizer: 第57回日本神経学会学術大会
  • Place of Presentation: 神戸国際会議場(神戸市中央区)
  • Year and Date: 2016-05-18
• [Presentation] マウス脳虚血再灌流モデルにおけるフマル酸ジメチルの神経保護効果 (2016)
  • Author(s): 南和志, 安部貴人, 塚田直己, 畝川美悠紀, 髙橋愼一, 鈴木則宏.
  • Organizer: 第41回日本脳卒中学会総会
  • Place of Presentation: 札幌市教育文化会館(札幌市中央区)
  • Year and Date: 2016-04-14
• [Presentation] オプトジェネティクスを用いた脳賦活による脳血流反応の空間伝播解析 (2015)
  • Author(s): 渡部竜志, 正本和人, 畝川美悠紀, 冨田裕, 田桑弘之, 菅野巖, 松井広, 田中謙二, 鈴木則宏
  • Organizer: 第4回ニューロフォトニクス研究会
  • Place of Presentation: ホテルグランドヒル市ヶ谷(東京都新宿区)
  • Year and Date: 2015-12-03
• [Presentation] 二光子顕微鏡を用いた生体マウス脳内ミクログリアの三次元長期イメージングと定量解析 (2015)
  • Author(s): 結城浩弥, 正本和人, 畝川美悠紀, 冨田裕, 鳥海春樹, 海老根妙子, 菅野巖, 鈴木則宏
  • Organizer: 第4回ニューロフォトニクス研究会
  • Place of Presentation: ホテルグランドヒル市ヶ谷(東京都新宿区)
  • Year and Date: 2015-12-03
• [Presentation] 家族性片麻痺性片頭痛２型モデルマウスにおける皮質拡延性抑制感受性および反応性 (2015)
  • Author(s): 畝川美悠紀, 池田啓子, 冨田裕, 鳥海春樹, 海老根妙子, 川上潔, 鈴木則宏
  • Organizer: 第43回日本頭痛学会総会
  • Place of Presentation: 京王プラザホテル(東京都新宿区)
  • Year and Date: 2015-11-13
• [Presentation] 大脳皮質性拡延性抑制が実質内穿通動脈口径と局所脳血流および二酸化炭素負荷に対する反応性に及ぼす影響 (2015)
  • Author(s): 畝川美悠紀, 冨田裕, 鳥海春樹, 長田高志, 正本和人, 菅野巖, 鈴木則宏
  • Organizer: 第27回日本脳循環代謝学会総会
  • Place of Presentation: 富山国際会議場(富山県富山市)
  • Year and Date: 2015-10-30
• [Presentation] Vasoreactivity of intracortical penetrating arteries of the cerebral cortex in response to cortical spreading depression and hypercapnia in anesthetized mice. (2015)
  • Author(s): Unekawa M, Tomita Y, Toriumi H, Osada T, Masamoto K, Kanno I, Suzuki N.
  • Organizer: 10th World Congress for Microcirculation
  • Place of Presentation: Kyoto International Conference Center(京都府京都市)
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] Dynamics of red blood cells in intraparenchymal capillaries and arterial diameter during cortical spreading depression observed with high-speed camera confocal fluorescence microscope in anesthetized mice. (2015)
  • Author(s): Tomita Y, Unekawa M, Toriumi H, Osada T, Masamoto K, Kawaguchi H, Itoh Y, Kanno I, Suzuki N.
  • Organizer: 10th World Congress for Microcirculation
  • Place of Presentation: Kyoto International Conference Center(京都府京都市)
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] Spatiotemporal dynamics of cerebral blood flow during focal activation with optogenetic photostimulation to the cortical neurons and astrocytes. (2015)
  • Author(s): Watanabe T, Masamoto K, Unekawa M, Toriumi H, Takuwa H, Kanno I, Matsui K, Tanaka K, Tomita Y, Suzuki N.
  • Organizer: 10th World Congress for Microcirculation
  • Place of Presentation: Kyoto International Conference Center(京都府京都市)
  • Year and Date: 2015-09-25
  • Int'l Joint Research
• [Presentation] Temporal diametric change of intracortical penetrating arteries in response to cortical spreading depression observed with two-photon microscopy in anesthetized mice (2015)
  • Author(s): Unekawa M, Tomita Y, Toriumi H, Osada T, Masamoto K, Kanno I, Suzuki N
  • Organizer: 27th International Symposium on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Vancouver Convention Centre (Vancouver, Canada)
  • Year and Date: 2015-06-27 – 2015-06-30
• [Presentation] The behavior of red blood cell in intraparenchymal capillaries during cortical spreading depression observed with high-speed camera confocal fluorescence microscope in anesthetized mice (2015)
  • Author(s): Tomita Y, Unekawa M, Toriumi H, Osada T, Masamoto K, Kawaguchi H, Itoh Y, Kanno I, Suzuki N
  • Organizer: 27th International Symposium on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Vancouver Convention Centre (Vancouver, Canada)
  • Year and Date: 2015-06-27 – 2015-06-30
• [Presentation] Astrocytic depolarization induced rapid and broad increase in CBF in in vivo mouse cortex (2015)
  • Author(s): Masamoto K, Unekawa M, Watanabe T, Toriumi H, Takuwa H, Kawaguchi H, Kanno I, Matsui K, Tanaka K, Tomita Y, Suzuki N
  • Organizer: 27th International Symposium on Cerebral Blood Flow Metabolism & Function
  • Place of Presentation: Vancouver Convention Centre (Vancouver, Canada)
  • Year and Date: 2015-06-27 – 2015-06-30
• [Presentation] Temporal diametric change of intracortical penetrating arteries in response to cortical spreading depression observed with two-photon microscopy in anesthetized mice. (2015)
  • Author(s): Unekawa M, Tomita Y, Toriumi H, Osada T, Masamoto K, Kanno I, Suzuki N.
  • Organizer: 27th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: バンクーバー(カナダ)
  • Year and Date: 2015-06-27
  • Int'l Joint Research
• [Presentation] The behavior of red blood cell in intraparenchymal capillaries during cortical spreading depression observed with high-speed camera confocal fluorescence microscope in anesthetized mice. (2015)
  • Author(s): Tomita Y, Unekawa M, Toriumi H, Osada T, Masamoto K, Kawaguchi H, Itoh Y, Kanno I, Suzuki N.
  • Organizer: 27th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: バンクーバー(カナダ)
  • Year and Date: 2015-06-27
  • Int'l Joint Research
• [Presentation] Astrocytic depolarization induced rapid and broad increase in CBFin in vivo mouse cortex. (2015)
  • Author(s): Masamoto K, Unekawa M, Watanabe T, Toriumi H, Takuwa H K, H., Kanno I, Matsui K, Tanaka K, Tomita Y, Suzuki N.
  • Organizer: 27th International Symposium on Cerebral Blood Flow, Metabolism & Function
  • Place of Presentation: バンクーバー(カナダ)
  • Year and Date: 2015-06-27
  • Int'l Joint Research
• [Presentation] Optogenetic activation of astrocyte-blood flow signaling in the anesthetized mouse cortex (2015)
  • Author(s): Tomita Y, Masamoto K, Unekawa M, Watanabe T, Toriumi H, Takuwa H, Kawaguchi H, Kanno I, Matsui K, Tanaka K, Suzuki N
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 新潟コンベンションセンター(新潟)
  • Year and Date: 2015-05-20 – 2015-05-23
• [Presentation] Optogenetic activation of astrocyte-blood flow signaling in the anesthetized mouse cortex. (2015)
  • Author(s): Tomita Y, Masamoto K, Unekawa M, Watanabe T, Toriumi H, Takuwa H, Kawaguchi H, Kanno I, Matsui K, Tanaka K, Suzuki N.
  • Organizer: 第56回日本神経学会学術大会
  • Place of Presentation: 朱鷺メッセ (新潟コンベンションセンター)(新潟県新潟市)
  • Year and Date: 2015-05-20
• [Presentation] 麻酔下マウスにおける大脳皮質性拡延性抑制誘発時の実質内穿通動脈の口径変化 (2014)
  • Author(s): 畝川美悠紀, 冨田裕, 鳥海春樹, 長田高志, 正本和人, 菅野巖, 鈴木則宏
  • Organizer: 第26回日本脳循環代謝学会総会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] アストロサイト賦活による局所脳血流反応の空間伝播の解析 (2014)
  • Author(s): 渡部竜志, 正本和人, 畝川美悠紀, 結城浩弥, 新夕雅啓, 鳥海春樹, 田桑弘之, 川口拓之, 菅野巖, 松井広, 田中謙二, 冨田裕, 鈴木則宏
  • Organizer: 第26回日本脳循環代謝学会総会
  • Place of Presentation: 岡山コンベンションセンター(岡山市)
  • Year and Date: 2014-11-21 – 2014-11-22
• [Presentation] 大脳皮質性拡延性抑制誘発時の脳表軟膜動脈および実質内穿通動脈の口径変化 (2014)
  • Author(s): 畝川美悠紀, 冨田裕, 鳥海春樹, 長田高志, 正本和人, 菅野巖, 鈴木則宏
  • Organizer: 第42回日本頭痛学会総会
  • Place of Presentation: 海峡メッセ下関(下関市)
  • Year and Date: 2014-11-14 – 2014-11-15
• [Presentation] Mechanism regulating D-serine and L-serine during transient middle cerebral artery occlusion in a mouse model (2014)
  • Author(s): Abe T, Sasabe J, Suzuki M, Takahashi S, Unekawa M, Iizumi T, Aiso S, Suzuki N
  • Organizer: 9th World Stroke Congress
  • Place of Presentation: Halic Congress Centre (Istanbul, Turkey)
  • Year and Date: 2014-10-22 – 2014-10-25