Elucidating the molecular mechanisms of neurodegeneration by genetic studies focused on the mechanisms of intracellular protein trafficking
Project/Area Number |
26350982
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Basic / Social brain science
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Research Institution | Toho University |
Principal Investigator |
SONE Masaki 東邦大学, 理学部, 准教授 (00397548)
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Co-Investigator(Kenkyū-buntansha) |
田村 拓也 東京医科歯科大学, 難治疾患研究所, 助教 (80396647)
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Co-Investigator(Renkei-kenkyūsha) |
OKAZAWA Hitoshi 東京医科歯科大学, 難治疾患研究所, 教授 (50261996)
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Project Period (FY) |
2014-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
|
Keywords | ショウジョウバエ / 神経変性 / 神経変性疾患 / アルツハイマー病 / 認知症 / 細胞内タンパク質輸送 / シナプス / 小胞輸送 |
Outline of Final Research Achievements |
We have clarified that abnormalities in the regulatory mechanisms of intracellular protein trafficking cause neurodegeneration. In this study, we focused on the Drosophila yata gene which regulates intracellular trafficking of APP that is a causative molecule of Alzheimer's disease. We revealed that specific inhibition of synaptic transport of APP significantly ameliorates the pathology of the Drosophila model of Alzheimer's disease. We also analyzed the causative molecule of frontotemporal dementia and found that impaired neural development causes neurodegeneration.
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Report
(4 results)
Research Products
(27 results)
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[Journal Article] HMGB1 facilitates repair of mitochondrial DNA damage and extends the lifespan of mutant ataxin-1 knock-in mice.2014
Author(s)
Ito H, Fujita K, Tagawa K, Chen X, Homma H, Sasabe T, Shimizu J, Shimizu S, Tamura T, Muramatsu S, Okazawa H.
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Journal Title
EMBO Mol Med.
Volume: 7
Issue: 1
Pages: 78-101
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Presentation] Systems biology analysis of Drosophila in vivo screen data elucidates core networks for DNAdamage repair in SCA1.2014
Author(s)
Takuya Tamura, Sam S. Berclay, Kyota Fujita, Hikaru Ito, Kazumi Motoki, Teppei Shimamura, Kazuhiko Tagawa, Asuka Katsuta, Hiroki Shiwaku, Masaki Sone, Seiya Imoto, Satoru Miyano, Hitoshi Okazawa
Organizer
第37回日本神経科学大会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2014-09-13
Related Report
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[Presentation] A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiplepolyglutamine diseases.2014
Author(s)
Kyota Fujita, Yoko Nakamura, Tsutomu Oka, Hikaru Ito, Takuya Tamura, Kazuhiko Tagawa, Toshikazu Sasabe, Asuka Katsuta, Kazumi Motoki, Hiroki Shiwaku, Chisato Yoshida, Masaki Sone, Hitoshi Okazawa
Organizer
第37回日本神経科学大会
Place of Presentation
パシフィコ横浜(神奈川県横浜市)
Year and Date
2014-09-12
Related Report
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