• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Parallel functional neural circuitry of the basal ganglia with regard to projection from cerebral cortex

Research Project

Project/Area Number 26350983
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionDoshisha University

Principal Investigator

Karube Fuyuki  同志社大学, 研究開発推進機構, 准教授 (60312279)

Co-Investigator(Kenkyū-buntansha) 高橋 晋  同志社大学, 脳科学研究科, 教授 (20510960)
Co-Investigator(Renkei-kenkyūsha) FUJIYAMA Fumino  同志社大学, 脳科学研究科, 教授 (20244022)
Project Period (FY) 2014-04-01 – 2018-03-31
Project Status Completed (Fiscal Year 2017)
Budget Amount *help
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords大脳基底核 / 大脳皮質 / 線条体 / 淡蒼球 / シナプス / 視床 / パルブアルブミン / 視床下核 / 淡蒼球外節 / 光遺伝学 / チャネルロドプシン / 運動野 / Calbindin
Outline of Final Research Achievements

The basal ganglia are important on motor behavior and learning, and also relates to various movement disorders. In this study, we investigated input/output neural circuitry involved in the basal ganglia, cerebral cortex, and thalamus, and found new insights on possible functions of the basal ganglia.
On the external segment of globus pallidus (GPe), one of the relay nuclei of the basal ganglia, we found three main cell population distinguished by molecular expression profiles and electrophysiological properties. One type of them massively inhibited dopaminergic neurons in substantia nigra pars compacta, and also was excited by application of Substance P. We also found direct cortical excitation of GPe neurons. In the striatum, we found parvalbumin-expressing interneurons were innervated by both motor thalamic nuclei and motor cortex and the rules of these two excitatory innervation differed from each other.

Report

(5 results)
  • 2017 Annual Research Report   Final Research Report ( PDF )
  • 2016 Research-status Report
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (26 results)

All 2018 2017 2016 2015 2014 Other

All Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (18 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Remarks (3 results)

  • [Journal Article] Parvalbumin-producing striatal interneurons receive excitatory inputs onto proximal dendrites from the motor thalamus in male mice2018

    • Author(s)
      Nakano Yasutake、Karube Fuyuki、Hirai Yasuharu、Kobayashi Kenta、Hioki Hiroyuki、Okamoto Shinichiro、Kameda Hiroshi、Fujiyama Fumino
    • Journal Title

      Journal of Neuroscience Research

      Volume: in press Issue: 7 Pages: 1186-1207

    • DOI

      10.1002/jnr.24214

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Substance P effects exclusively on prototypic neurons in mouse globus pallidus2017

    • Author(s)
      Mizutani Kazuko、Takahashi Susumu、Okamoto Shinichiro、Karube Fuyuki、Fujiyama Fumino
    • Journal Title

      Brain structure and function

      Volume: 222 Issue: 9 Pages: 4089-4110

    • DOI

      10.1007/s00429-017-1453-8

    • Related Report
      2017 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal circuits and physiological roles of the basal ganglia in terms of transmitters, receptors and related disorders. The Journal of Physiological Sciences.2016

    • Author(s)
      Yamada K, Takahashi S, Karube F, Fujiyama F, Kobayashi K, Nishi A, Momiyama T
    • Journal Title

      The Journal of Physiological Sciences

      Volume: 0 Issue: 6 Pages: 1-12

    • DOI

      10.1007/s12576-016-0445-4

    • Related Report
      2016 Research-status Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations.2016

    • Author(s)
      Oh Y-M, Karube F, Takahashi S, Kobayashi K, Takada M, Uchigashima M, Watanabe M, Nishizawa K, Kobayashi K, *Fujiyama F
    • Journal Title

      Brain Struct Funct

      Volume: 印刷中 Issue: 5 Pages: 2359-2378

    • DOI

      10.1007/s00429-016-1346-2

    • Related Report
      2016 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Morphological elucidation of basal ganglia circuits contributing reward prediction2015

    • Author(s)
      2.Fujiyama, S., Takahashi, S., and Karube, F.
    • Journal Title

      Frontiers in Neuroscience

      Volume: 9:6 Pages: 1-8

    • DOI

      10.3389/fnins.2015.00006

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Direct cortical innervation modulates excitability of globus pallidal neurons in rodents2018

    • Author(s)
      Karube F, Fujiyama F
    • Organizer
      第123回日本解剖学会全国学術集会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 視床・大脳皮質運動野の線条体パルブアルブミン発現介在ニューロンへの投射2017

    • Author(s)
      中野 泰岳、苅部 冬紀、藤山 文乃
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] Using a novel PV-Cre rat model to characterize pallidonigral cells and their terminations2017

    • Author(s)
      呉 胤美、苅部 冬紀、高橋 晋、小林 憲太、高田 昌彦、小林、和人、藤山 文乃
    • Organizer
      第122回日本解剖学会総会・全国学術集会
    • Place of Presentation
      長崎大学(長崎県長崎市)
    • Year and Date
      2017-03-28
    • Related Report
      2016 Research-status Report
  • [Presentation] PV-Creラットモデルを用いた淡蒼球外節細胞の黒質ドーパミン細胞への抑制性入力の解明2017

    • Author(s)
      呉 胤美, 苅部 冬紀, 高橋 晋, 小林 憲太, 小林 和人, 藤山 文乃
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] 視床・大脳皮質運動野の線条体パルブアルブミン発現介在ニューロンへの投射2017

    • Author(s)
      中野 泰岳, 苅部 冬紀, 藤山 文乃
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] サブスタンスPはマウス淡蒼球外節のPrototypic neuronsへ特異的に影響を及ぼす2017

    • Author(s)
      水谷 和子, 高橋 晋, 岡本 慎一郎, 苅部 冬紀, 藤山 文乃
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] げっ歯類における皮質―淡蒼球経路:形態学的・電気生理学的同定2017

    • Author(s)
      苅部 冬紀, 高橋 晋、藤山 文乃
    • Organizer
      第40回日本神経科学大会
    • Related Report
      2017 Annual Research Report
  • [Presentation] Morphological and electrophysiological evaluation of cortico-pallidal pathway in rodent2017

    • Author(s)
      Karube F., Takahashi S., Fujiyama F
    • Organizer
      XXIII World Congress of Neurology
    • Related Report
      2017 Annual Research Report
    • Int'l Joint Research
  • [Presentation] パーキンソン病モデルマウスの一次運動野における光遺伝学を活用した神経細胞活動の操作2016

    • Author(s)
      高橋 晋、小林 憲太、苅部 冬紀、藤山 文乃
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] マウス淡蒼球外節におけるNeurokinin-1受容体陽性細胞の形態学的・電気生理学的性質を解明する2016

    • Author(s)
      水谷 和子、苅部 冬紀、高橋 晋、藤山 文乃
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 淡蒼球外節から黒質緻密部ドーパミンニューロンへの抑制性入力を解明する2016

    • Author(s)
      呉 胤美、苅部 冬紀、高橋 晋、小林 憲太、高田 昌彦、小林、和人、藤山 文乃
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県横浜市)
    • Year and Date
      2016-07-20
    • Related Report
      2016 Research-status Report
  • [Presentation] 前脳基底部コリン作動性システムの長期記憶想起への貢献2015

    • Author(s)
      相馬 祥吾、末松 尚志、苅部 冬紀、藤山 文乃、七五三木聡
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・国際展示場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] 電気穿孔法による、遅延反応課題の遅延期間において持続的な活動を示すラット内側前頭連合野ニューロンの形態学的同定2015

    • Author(s)
      小山 佳、舘山 幸菜、Cheuk Wa Christopher Lo、大原 慎也、苅部 冬紀、藤山 文乃、飯島 敏夫、筒井 健一郎
    • Organizer
      第38回日本神経科学大会
    • Place of Presentation
      神戸国際会議場・国際展示場
    • Year and Date
      2015-07-28
    • Related Report
      2015 Research-status Report
  • [Presentation] Searching for inter-relationship between cortico-striatal and cortico-subthalamic nucleus projections.2015

    • Author(s)
      Karube F, Fujiyama F.
    • Organizer
      生理研研究会
    • Place of Presentation
      生理学研究所 (愛知県岡崎市)
    • Year and Date
      2015-01-09 – 2015-01-10
    • Related Report
      2014 Research-status Report
  • [Presentation] The topography of striatopallidal projections and calbindin immunoreactive subdivisions.2014

    • Author(s)
      Mizutani K, Karube F, Oh YM, Nakano Y, Fujiyama F.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Immunohistochemical compartments of the globus pallidus and their projection pattern.2014

    • Author(s)
      Oh YM, Mizutani K, Nakano Y, Unzai T, Karube F, Fujiyama F.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
  • [Presentation] Anatomical aspect of the basal ganglia circuitry, in relation to cortical projection.2014

    • Author(s)
      Karube F, Fujiyama F.
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜 (神奈川県横浜市)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] The micro-circuitry of the basal ganglia in relation to cortical innervation、2014

    • Author(s)
      Karube F, Fujiyama F.
    • Organizer
      NIPS International Workshop
    • Place of Presentation
      生理学研究所 (愛知県岡崎市)
    • Year and Date
      2014-09-08
    • Related Report
      2014 Research-status Report
    • Invited
  • [Remarks] 科学研究科 学生・中野泰岳さん(神経回路形態部門所属)の論文

    • URL

      http://brainscience.doshisha.ac.jp/news/2018/0109/news-detail-124.html

    • Related Report
      2017 Annual Research Report
  • [Remarks] 同志社大学脳科学研究科ホームページ

    • URL

      http://brainscience.doshisha.ac.jp/news/2017/0206/news-detail-93.html

    • Related Report
      2016 Research-status Report
  • [Remarks] 同志社大学大学院脳科学研究科・システム脳科学分野(神経回路形態部門)ホームページ

    • URL

      http://brainscience.doshisha.ac.jp/introduction/sys/nc.html

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-04-04   Modified: 2019-03-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi