| Project/Area Number |
26350984
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Basic / Social brain science
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| Research Institution | Tokushima Bunri University |
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Principal Investigator |
Song Si-Young 徳島文理大学, 大学共同利用機関等の部局等, 教授 (00399693)
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| Co-Investigator(Kenkyū-buntansha) |
中島 健太郎 徳島文理大学, 大学共同利用機関等の部局等, 助手 (20449911)
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| Research Collaborator |
安達 栄治郎 北里大学, 医療系研究科・細胞組織再生医学
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| Project Period (FY) |
2014-04-01 – 2018-03-31
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| Project Status |
Completed (Fiscal Year 2017)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2016: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | SCD / アルツハイマー病 / 病態モデルマウス / 樹状突起 / シナプス / 免疫組織化学 / laser microdissection / 病態モデル |
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| Outline of Final Research Achievements |
Analyses by immunohistochemistry, in situ hybridization and real-time PCR revealed SCD2 dominant, rather than SCD1, expression was detected in neurons of mice. SCD-immunoreactivity (IR) tends to distribute in thin dendritic processes showing fine granular patterns during postnatal development, but increased SCD-IR was detected in 3 x Tg AD mice as compared with wild type mice at postnatal six months, showing coarse granular and segmental distribution in dendrites. Relatively large spines, swollen like a bead, were observed along dendrite and synaptobrevin-IR was decreased. These findings suggest the possibility that early lesions of AD appear in dendrite of the hippocampus and SCD is involved in the processes
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