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Neural mechanisms for formation of impulsivity and self-control in intertemporal choice behavior

Research Project

Project/Area Number 26350986
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Basic / Social brain science
Research InstitutionKeio University (2015-2016)
Tokyo Institute of Technology (2014)

Principal Investigator

Jimura Koji  慶應義塾大学, 理工学部(矢上), 准教授 (80431766)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2016: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2015: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords意思決定 / 前頭前野 / 腹側線条体 / 機能的MRI / 異時的意思決定 / 衝動性 / 自己制御 / 実行制御 / 線条体 / 報酬学習 / 認知制御
Outline of Final Research Achievements

The current study aimed to elucidate neural mechanisms underlying formation of impulsivity and self-control in intetemporal choice behavior. During fMRI scanning, human participants performed an intertemporal choice task in which they first directly experienced delayed liquid rewards, followed by free choice trials. Formation of self-control was associated with temporal dynamics of anticipatory utility in the anterior prefrontal cortex (aPFC) during delay period, whereas that of impulsivity was associated with reverse dynamics in ventral striatum (VS). During consumption of delayed rewards, impulsive individuals showed greater activity in aPFC and VS and stronger functional connectivity from aPFC to VS. On the other hand, difficulty in decision-making was associated with prefrontal control mechanisms during choice.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (5 results)

All 2017 2016

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Acknowledgement Compliant: 1 results) Presentation (4 results)

  • [Journal Article] Intertemporal decision-making involves prefrontal control mechanisms associated with working memory2017

    • Author(s)
      Jimura K, Chushak M, Westbrook A, Braver TS
    • Journal Title

      Cereb Cortex

      Volume: 印刷中 Issue: 4 Pages: 1105-1116

    • DOI

      10.1093/cercor/bhx015

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Int'l Joint Research / Acknowledgement Compliant
  • [Presentation] Prefrontal-temporal mechanisms involved in response inhibition under perceptual uncertainty2017

    • Author(s)
      Tsumura K, Aoki R, Nakahara K, Huk A, Polrack RA, Jimura K
    • Organizer
      第40回日本神経科学大会
    • Place of Presentation
      幕張メッセ(千葉県・千葉市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Prefrontal-Striatum mechanisms involved in formation of self-controlled choice2017

    • Author(s)
      Tanaka D, Aoki R, Nakahara K, Jimura K
    • Organizer
      第40回日本神経科学大会
    • Place of Presentation
      幕張メッセ(千葉県・千葉市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Periodic polarization of brain-wide functional network revealed by resting-state fMRI2016

    • Author(s)
      Noro Y, Jimura K
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Prefrontal-striatal mechanisms of impulsivity during reward attainment2016

    • Author(s)
      Misonou A, Jimura K
    • Organizer
      第39回日本神経科学大会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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