A layer structure map of the monkey frontal-lobe by current source density analysis using multi-contact electrode

• Project/Area Number: 26350991
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Brain biometrics
• Research Institution: Tohoku University
• Principal Investigator: Sakamoto Kazuhiro 東北大学, 医学系研究科, 非常勤講師 (80261569)
• Co-Investigator(Renkei-kenkyūsha): MUSHIAKE Hajime 東北大学, 医学系研究科, 教授 (80219849)
• Research Collaborator: KAWAGUCHI Norihiko 東北医科薬科大学, 医学部, 助教
• Project Period (FY): 2014-04-01 – 2017-03-31
• Project Status: Completed (Fiscal Year 2016)
• Budget Amount: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000); Fiscal Year 2016: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2015: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: サル / 前頭前野 / 運動前野 / LFP / 電流源解析 / 形操作課題 / 外側前頭前野 / 背側運動前野 / ウェーブレット解析 / 局所電場電位 / 周波数－時間解析 / 前頭葉 / 多重電極 / 生理学的マップ

Outline of Final Research Achievements

Current source (CSD) analysis was performed on the local field potential (LFP) recorded with a multi-contact electrode from the monkey lateral prefrontal cortex (lPFC) and the dorsal premotor area (PMd) while executing a shape manipulation task. In the lPFC, a current sink, considered to be an excitatory synaptic input, was observed in the deep layer just before the first visual stimulus (sample stimulus) was presented. It was also found that this current sink corresponds to a transient α-θ-δ wave (13 - 3 Hz) component. On the other hand, in the PMd, current sink was seen in the middle layer during the second visual stimulus (test stimulus) presentation period. This component was correlated with a persistent low beta wave (<20 Hz). These results would greatly contribute to elucidating the dynamics of the local circuits and the functional differentiation of the two areas.

Research Products

• [Journal Article] Current source density analysis on local field potentials in monkey dorsal premotor cortex during a shape-manipulation task (2017)
  • Author(s): Kazuhiro SAKAMOTO, Norihiko KAWAGUCHI, Hajime MUSHIAKE
  • Journal Title: J Physiological Science Volume: 67
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] “Figure” Salience as a Meta-Rule for Rule Dynamics in Visual Perception (2016)
  • Author(s): Kazuhiro SAKAMOTO
  • Journal Title: Lecture Notes in Computer Science Volume: 9948 Pages: 381-390
  • DOI: 10.1007/978-3-319-46672-9_43
  • ISBN: 9783319466712, 9783319466729
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] &ldquo;Surprise&rdquo; Neurons in the Supplementary Eye Field of the Cerebral Cortex and Exploration-exploitation Trade-off (2016)
  • Author(s): 坂本 一寛, 川口 典彦, 虫明 元.
  • Journal Title: The Brain & Neural Networks Volume: 23 Issue: 1 Pages: 41-45
  • DOI: 10.3902/jnns.23.41
  • NAID: 130005150462
  • ISSN: 1340-766X, 1883-0455
  • Acknowledgement Compliant
• [Journal Article] Seven Years of the Workshop for Synergetics between Neuroscience, Rehabilitation and Robotics (2016)
  • Author(s): 坂本 一寛, 我妻 広明, 橘 香織
  • Journal Title: The Brain & Neural Networks Volume: 23 Issue: 4 Pages: 169-175
  • DOI: 10.3902/jnns.23.169
  • NAID: 130005308103
  • ISSN: 1340-766X, 1883-0455
  • Acknowledgement Compliant
• [Journal Article] 神経回路のレジリエンスと発火ゆらぎ (2015)
  • Author(s): 坂本 一寛
  • Journal Title: システム/制御/情報 Volume: 59 Pages: 342-347
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Surprise signals in the supplementary eye field: fectified prediction errors drive exploration-exploitation transitions. (2015)
  • Author(s): Kawaguchi N, Sakamoto K, Saito N, Furusawa Y, Tanji J, Aoki M, Mushiake H
  • Journal Title: J Neurophysiol Volume: 113 Issue: 3 Pages: 1001-1014
  • DOI: 10.1152/jn.00128.2014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Spatiotemporal patterns of current source density in the prefrontal cortex of a behaving monkey. (2015)
  • Author(s): Sakamoto K, Kawaguchi N, Yagi K, Mushiake H.
  • Journal Title: Neural Networks Volume: 62 Pages: 67-73
  • DOI: 10.1016/j.neunet.2014.06.009
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Excitation-inhibition balance of prefrontal neurons during the execution of a path-planning task. (2015)
  • Author(s): Sakamoto K, Naohiro S, Yoshida S, Mushiake H.
  • Journal Title: Advances in Cognitive Neurodynamics Volume: 4 Pages: 547-552
  • DOI: 10.1007/978-94-017-9548-7_79
  • ISBN: 9789401795470, 9789401795487
  • Peer Reviewed
• [Journal Article] Increase of Firing Variability of Prefrontal Neurons as an Early Warning Signal of Problem Solving (2015)
  • Author(s): 坂本一寛
  • Journal Title: Seibutsu Butsuri Volume: 55 Issue: 1 Pages: 015-018
  • DOI: 10.2142/biophys.55.015
  • NAID: 130004794732
  • ISSN: 0582-4052, 1347-4219
  • Peer Reviewed
• [Journal Article] The Divergence-Convergence Structure of Neurinal Wiring as Voting to Parameter Space: A Hypothesis for Implementation of Abduction (2014)
  • Author(s): 坂本一寛
  • Journal Title: The Brain & Neural Networks Volume: 21 Issue: 3 Pages: 136-148
  • DOI: 10.3902/jnns.21.136
  • NAID: 130004713866
  • ISSN: 1340-766X, 1883-0455
• [Presentation] 形操作課題中のサル背側運動前野の局所場電位に対する電流源解析 (2017)
  • Author(s): 坂本一寛,川口典彦,虫明元
  • Organizer: 第94回日本生理学会大会
  • Place of Presentation: アクトシティ浜松（静岡県浜松市）
  • Year and Date: 2017-03-28
• [Presentation] Interactions of local field potentials between monkey lateral prefrontal and dorsal premotor cortices during a shape-manipulation task (2016)
  • Author(s): Kazuhiro SAKAMOTO, Norihiko KAWAGUCHI, Hajime MUSHIAKE
  • Organizer: The 39th annual meeting of the Japan Neuroscience Society
  • Place of Presentation: パシフィコ横浜（神奈川県横浜市）
  • Year and Date: 2016-07-20
  • Int'l Joint Research
• [Presentation] 新しいマルチスケール in vivo 脳機能イメージング (2016)
  • Author(s): 小山内 実、菊田 里美、坂本 一寛、笠原 二郎、幸村 裕治、本間 経康、柳川 右千夫、虫明 元
  • Organizer: 第93回日本生理学会大会
  • Place of Presentation: 札幌コンベンションセンター（北海道札幌市）
  • Year and Date: 2016-03-22
• [Presentation] サルの洗練された知識利用行動から探索行動への移行は単純な行動‐結果強化学習では説明されない (2016)
  • Author(s): 坂本一寛
  • Organizer: 第48回東北生理談話会
  • Place of Presentation: 岩手医科大学（岩手県盛岡市）
• [Presentation] Local field potentials in monkey prefrontal cortex during a shape-manipulation task (2015)
  • Author(s): Sakamoto K, Kawaguchi N, Mushiake H
  • Organizer: International Symposium on Prediction and Decision Making 2015
  • Place of Presentation: 東京大学（東京都文京区）
  • Year and Date: 2015-10-31
• [Presentation] 高次脳機能の背後にある神経回路動態を多元的生体信号解析より解明する (2015)
  • Author(s): 坂本一寛, 小山内実, 虫明元
  • Organizer: 第25回インテリジェント・システム・シンポジウム
  • Place of Presentation: 東北大学（宮城県仙台市）
  • Year and Date: 2015-09-24
• [Presentation] In Vivoサル脳への固有信号内視鏡の適用 (2015)
  • Author(s): 坂本一寛, 小山内実, 虫明元
  • Organizer: 日本神経回路学会第25回全国大会
  • Place of Presentation: 東京電機大学（東京都調布市）
  • Year and Date: 2015-09-02
• [Presentation] Local field potentials in monkey dorsal premotor cortex during a shape-manipulation task. (2015)
  • Author(s): Sakamoto K, Kawaguchi N, Mushiake H
  • Organizer: The 38th annual meeting of the Japan Neuroscience Society.
  • Place of Presentation: 神戸コンベンションセンター（兵庫県神戸市）
  • Year and Date: 2015-07-28
  • Int'l Joint Research
• [Presentation] Cooperativity between working memory and behavioral planning in the monkey prefrontal cortex. (2015)
  • Author(s): Sakamoto K, Saito N, Yoshida S, Mushiake H
  • Organizer: IBRO2015
  • Place of Presentation: リオ・デ・ジャネイロ（ブラジル）
  • Year and Date: 2015-07-07
  • Int'l Joint Research
• [Presentation] サル前頭葉におけるLFP周波数掃引 (2015)
  • Author(s): 坂本一寛, 川口典彦, 八木耕平, 虫明 元.
  • Organizer: 日本物理学会第70回年次大会
  • Place of Presentation: 東京・日本
  • Year and Date: 2015-03-21 – 2015-03-24
• [Presentation] Spatiotemporal properties of current source density in the prefrontal cortices of behaving monkeys. (2014)
  • Author(s): Kawaguchi N, Sakamoto K, Yagi K, Aoki M, Mushiake H.
  • Organizer: Neuroscience 2014
  • Place of Presentation: ワシントンD.C.・アメリカ
  • Year and Date: 2014-11-15 – 2014-11-19
• [Presentation] Current sink and source patterns in the prefrontal cortex of a behaving monkey. (2014)
  • Author(s): Sakamoto K, Kawaguchi N, Yagi K, Matsuzaka Y, Katayama N, Tanaka T, Mushiake H.
  • Organizer: International Symposium on Nonlinear Theory and its Applications
  • Place of Presentation: ルツェルン・スイス
  • Year and Date: 2014-09-14 – 2014-09-18
• [Presentation] Local field potentials in monkey prefrontal cortex during a shape-manipulation task. (2014)
  • Author(s): Kawaguchi N, Sakamoto K, Yagi K, Aoki M, Mushiake H.
  • Organizer: Neurosience 2014
  • Place of Presentation: 横浜・日本
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Alpha-theta oscillations at task initiation in the monkey prefrontal cortex. (2014)
  • Author(s): Sakamoto K, Kawaguchi N, Yagi K, Mushiake H.
  • Organizer: The 24th Annual Conference of the Japanese Neural Network Society
  • Place of Presentation: 函館・日本
  • Year and Date: 2014-08-27 – 2014-08-30
• [Presentation] サル前頭前野電流源パタンの評価 (2014)
  • Author(s): 坂本一寛, 川口典彦, 八木耕平, 片山統裕, 田中徹, 虫明元.
  • Organizer: 第53回日本生体医工学会大会
  • Place of Presentation: 仙台・日本
  • Year and Date: 2014-06-24 – 2014-06-26