Relationship between applied behavior analysis and therapeutics in animal models of ADHD
Project/Area Number |
26380894
|
Research Category |
Grant-in-Aid for Scientific Research (C)
|
Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Educational psychology
|
Research Institution | Fukuoka Prefectural University |
Principal Investigator |
Mugishima Go 福岡県立大学, 人間社会学部, 准教授 (40308143)
|
Project Period (FY) |
2014-04-01 – 2017-03-31
|
Project Status |
Completed (Fiscal Year 2016)
|
Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
|
Keywords | 実験系心理学 / 発達障害 / 生理心理学 / 行動分析学 / 注意欠陥多動性障害 / モデル動物研究 / 衝動性 / 注意 / 遅延価値割引 / 実験行動分析 / 行動薬理学 / 事象関連電位 |
Outline of Final Research Achievements |
ADHD (attention deficit hyperactivity disorder) is a developmental disorder to assume cardinal symptoms including inattention, impulsivity and hyperactivity, which is assumed some neural dysfunctions related catecholamine neuron. In this study, impulsivity and inattention ware investigated in EL mouse and spontaneously hypertensive rat (SHR) as animal models of ADHD. As the results, 1) EL mouse put much higher value on immediacy than amount of reward on delay discount paradigm, suggesting high impulsivity. 2)Atomoxetine alleviated the impulsive choice in EL mouse. 3) EL mouse exhibited impaired performance on latent inhibition, suggesting inattention. 4) SHR showed insufficient mismatch negativity like response on cerebral cortex to the acoustic stimuli that elicited stream segregation, indicating pre-attentive dysfunction in segregating stream. Methylphenidate alleviated this pre-attentive dysfunction, although induced the ADHD like response of EEG on control strain (WKY) adversely.
|
Report
(4 results)
Research Products
(19 results)
-
-
-
-
-
-
-
-
-
[Presentation] Attenuated latent inhibition of taste aversion learning in EL mouse as an animal model of ADHD.2015
Author(s)
Mugishima, G., Kubo, H., Saka, N., Nagai, T., Isozaki, S., Kimura, H., Shinba, T.
Organizer
The 75th Annual Meeting of the Japanese Society for Animal Psychology
Place of Presentation
Japan Woman's University, Mejiro Compus (Bunkyo-ku, Tokyo, Japan)
Year and Date
2015-09-10
Related Report
-
[Presentation] The effect of methylphenidate on the evoked potential to auditory paired stimulation in SHR as an animal model of ADHD.2015
Author(s)
Saka, N., Shinba, T., Kubo, H., Miyagawa, Y., Hayashi, M., Kimura, H., Mugishima, G.
Organizer
The 75th Annual Meeting of the Japanese Society for Animal Psychology
Place of Presentation
Japan Woman's University, Mejiro Compus (Bunkyo-ku, Tokyo, Japan)
Year and Date
2015-09-10
Related Report
-
-
-
-
-
[Presentation] Effects of methylphenidate administration on mismatch negativity-like response in spontaneously hypertensive rat (SHR) as an animal model of ADHD.2014
Author(s)
Mugishima, G., Kubo, H., Saka, N., Nabeta, M., Hayashi, M., Kimura, H., Shinba, T.
Organizer
The 74th Annual Meeting of the Japanese Society for Animal Psychology
Place of Presentation
Inuyama, Aichi
Year and Date
2014-07-19 – 2014-07-21
Related Report
-
[Presentation] On the subjective equivalence between amount and delay in EL mouse as an animal model of ADHD.2014
Author(s)
Kubo, H., Kimura, H., Nakano, K., Nagai, T., Nomiyama, H., Hayashi, N., Nakamoto, Y., Yoshii, M., Mugishima, G.
Organizer
The 74th Annual Meeting of the Japanese Society for Animal Psychology
Place of Presentation
Inuyama, Aichi
Year and Date
2014-07-19 – 2014-07-21
Related Report
-
[Presentation] Mismatch negativity-like response on stream segregation in spontaneously hypertensive rat (SHR) as an animal model of ADHD. 2014年7月 The 74th Annual Meeting of the Japanese Society for Animal Psychology.2014
Author(s)
Saka, N., Shinba, T., Kubo, H., Nabeta, M., Hayashi, M., Kimura, H., Mugishima, G.
Organizer
The 74th Annual Meeting of the Japanese Society for Animal Psychology
Place of Presentation
Inuyama, Aichi
Year and Date
2014-07-19 – 2014-07-21
Related Report
-
-