| Project/Area Number |
26380894
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Educational psychology
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| Research Institution | Fukuoka Prefectural University |
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Principal Investigator |
Mugishima Go 福岡県立大学, 人間社会学部, 准教授 (40308143)
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2016: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
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| Keywords | 実験系心理学 / 発達障害 / 生理心理学 / 行動分析学 / 注意欠陥多動性障害 / モデル動物研究 / 衝動性 / 注意 / 遅延価値割引 / 実験行動分析 / 行動薬理学 / 事象関連電位 |
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| Outline of Final Research Achievements |
ADHD (attention deficit hyperactivity disorder) is a developmental disorder to assume cardinal symptoms including inattention, impulsivity and hyperactivity, which is assumed some neural dysfunctions related catecholamine neuron. In this study, impulsivity and inattention ware investigated in EL mouse and spontaneously hypertensive rat (SHR) as animal models of ADHD. As the results, 1) EL mouse put much higher value on immediacy than amount of reward on delay discount paradigm, suggesting high impulsivity. 2)Atomoxetine alleviated the impulsive choice in EL mouse. 3) EL mouse exhibited impaired performance on latent inhibition, suggesting inattention. 4) SHR showed insufficient mismatch negativity like response on cerebral cortex to the acoustic stimuli that elicited stream segregation, indicating pre-attentive dysfunction in segregating stream. Methylphenidate alleviated this pre-attentive dysfunction, although induced the ADHD like response of EEG on control strain (WKY) adversely.
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