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Central ketone body and brain function including sleep regulation

Research Project

Project/Area Number 26380987
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental psychology
Research InstitutionThe University of Tokushima

Principal Investigator

CHIKAHISA Sachiko  徳島大学, 大学院医歯薬学研究部(医学系), 講師 (00452649)

Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2015: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywordsケトン体 / 高次脳機能 / 睡眠 / 脳機能 / エネルギー代謝
Outline of Final Research Achievements

We investigated the role of brain ketone body metabolism in brain functions including sleep regulations. Chronic sleep disruption decreased sleep amount and attenuated sleep depth, accompanying by glucose intolerance in mice. These sleep-disrupted mice showed no change in plasma ketone body concentration, although both central and peripheral injection of ketone bodies enhanced sleep depth. In addition, neuron-specific over expression of ketone body-degrading enzyme induced alteration of sleep rebound after sleep deprivation, anxiety/depression and memory/learning behavior. Central ketone body metabolism may play a significant role in higher brain functions including sleep homeostasis.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (17 results)

All 2017 2016 2015 2014

All Journal Article (6 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (10 results) (of which Int'l Joint Research: 1 results,  Invited: 5 results) Book (1 results)

  • [Journal Article] Wake-promoting effects of ONO-4127Na, a prostaglandin DP1 receptor antagonist, in hypocretin/orexin deficient narcoleptic mice.2016

    • Author(s)
      Sagawa Y, Sato M, Sakai N, Chikahisa S, Chiba S, Maruyama T, Yamamoto J, Nishino S
    • Journal Title

      Neuropharmacology

      Volume: 110 Pages: 268-276

    • DOI

      10.1016/j.neuropharm.2016.07.013

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Late feeding in the active period decreases slow-wave activity.2016

    • Author(s)
      Oura K, Otsuka A, Shiuchi T, Chikahisa S, Shimizu N, Sei H
    • Journal Title

      Life Science

      Volume: 160 Pages: 18-26

    • DOI

      10.1016/j.lfs.2016.07.005

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sleep as a biological problem: an overview of frontiers in sleep research2016

    • Author(s)
      Kanda T, Tsujino N, Kuramoto E, Koyama Y, Susaki EA, Chikahisa S, Funato H
    • Journal Title

      J Physiol Sci

      Volume: 66 Issue: 1 Pages: 1-13

    • DOI

      10.1007/s12576-015-0414-3

    • Related Report
      2016 Annual Research Report 2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ヒスタミンと睡眠調節-ヒスタミン神経系とマスト細胞の役割-2016

    • Author(s)
      近久幸子,勢井宏義
    • Journal Title

      睡眠医療

      Volume: 10 Pages: 35-42

    • Related Report
      2015 Research-status Report
  • [Journal Article] Voluntary exercise and increased food intake after mild chronic stress improve social avoidance behavior in mice.2015

    • Author(s)
      Otsuka A, Shiuchi T, Chikahisa S, Shimizu N, Sei H
    • Journal Title

      Physiology & Behavior

      Volume: 151 Pages: 2642-2671

    • DOI

      10.1016/j.physbeh.2015.07.024

    • Related Report
      2015 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ketone body metabolism and sleep homeostasis in mice2014

    • Author(s)
      Chikahisa S, Shimizu N, Shiuchi T, Sei H
    • Journal Title

      Neuropharmacology

      Volume: 79 Pages: 399-404

    • DOI

      10.1016/j.neuropharm.2013.12.009

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 脳内肥満細胞の睡眠覚醒調節における役割2017

    • Author(s)
      近久幸子、清水紀之、大塚愛理、志内哲也、西野精治、勢井宏義
    • Organizer
      第12回環境生理プレコングレス
    • Place of Presentation
      サーラシティ浜松(静岡県・浜松市)
    • Related Report
      2016 Annual Research Report
  • [Presentation] Sleep loss induces diabetes in mice model2016

    • Author(s)
      Chikahisa S, Harada S, Shimizu N, Shiuchi T, Nishino S, Sei H
    • Organizer
      Neuroscience 2016
    • Place of Presentation
      San Diego (USA)
    • Year and Date
      2016-11-12
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 睡眠障害モデルマウスの糖代謝異常におけるマストセルの関与2016

    • Author(s)
      近久幸子、清水紀之、志内哲也、西野精二、勢井宏義
    • Organizer
      日本睡眠学会第41回定期学術集会
    • Place of Presentation
      京王プラザホテル(東京都・新宿区)
    • Year and Date
      2016-07-07
    • Related Report
      2016 Annual Research Report
  • [Presentation] ケトン体による睡眠ホメオスタシス調節機構2015

    • Author(s)
      近久幸子,勢井宏義
    • Organizer
      日本睡眠学会第40回定期学術集会
    • Place of Presentation
      栃木県総合文化センター・宇都宮東武ホテルグランデ(栃木県・宇都宮市)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 睡眠覚醒調節における脳内マストセルの関与2015

    • Author(s)
      近久幸子,西野精治,勢井宏義
    • Organizer
      日本睡眠学会第40回定期学術集会
    • Place of Presentation
      栃木県総合文化センター・宇都宮東武ホテルグランデ(栃木県・宇都宮市)
    • Year and Date
      2015-07-02
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] Contribution of PPARa and Ketone Body to Sleep Homeostasis in Mice2015

    • Author(s)
      Chikahisa S, Shimizu N, Shiuchi T, Shiuchi T, Sei H
    • Organizer
      Experimental Biology
    • Place of Presentation
      Boston (USA)
    • Year and Date
      2015-03-28 – 2015-04-01
    • Related Report
      2014 Research-status Report
  • [Presentation] 睡眠ホメオスタシス機構におけるPPARsおよびケトン体代謝の関与2015

    • Author(s)
      近久幸子,勢井宏義
    • Organizer
      第92回 日本生理学会大会
    • Place of Presentation
      神戸国際会議場・展示場 (兵庫県・神戸市)
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Sleep quality affects glucose homeostasis in a mouse model2014

    • Author(s)
      Chikahisa S, Harada S, Shimizu N, Shiuchi T, Sei H
    • Organizer
      Homeodynamics in Clocks, Sleep and Metabolism, Tokyo Translational Therapeutics Meeting
    • Place of Presentation
      東京大学 (東京都・文京区)
    • Year and Date
      2014-09-24
    • Related Report
      2014 Research-status Report
  • [Presentation] 中枢ケトン体代謝による睡眠ホメオスタシス調節2014

    • Author(s)
      近久幸子,勢井宏義
    • Organizer
      日本睡眠学会第39回定期学術集会
    • Place of Presentation
      あわぎんホール (徳島県・徳島市)
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 脳内肥満細胞の睡眠覚醒調節における役割2014

    • Author(s)
      近久幸子,児玉亨,征矢敦至,佐川洋平,石丸雄二,勢井宏義,西野精治
    • Organizer
      日本睡眠学会第39回定期学術集会
    • Place of Presentation
      あわぎんホール (徳島県・徳島市)
    • Year and Date
      2014-07-03 – 2014-07-04
    • Related Report
      2014 Research-status Report
    • Invited
  • [Book] 実験医学2016

    • Author(s)
      西中村隆一、小林明雄、太口敦博、淺沼克彦、柴田茂、柳田素子、馬場理也、鈴木健弘、北条浩彦、村山泰斗、早河翼、水谷玲奈、三浦重徳、近久幸子、藤井正幸、谷上賢瑞、宮川信一、宮本圭、板鼻康至、木戸屋浩康
    • Total Pages
      141
    • Publisher
      羊土社
    • Related Report
      2016 Annual Research Report

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Published: 2014-04-04   Modified: 2018-03-22  

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