An experimental study of neuroendocrinological mechanisms underlying vulnerability to emotional disorders in pregnant and postpartum women.
| Project/Area Number |
26380990
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Research Field |
Experimental psychology
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| Research Institution | Kagoshima University |
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Principal Investigator |
TOMIHARA KAZUYA 鹿児島大学, 法文教育学域法文学系, 教授 (00272146)
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| Co-Investigator(Kenkyū-buntansha) |
小川 園子 筑波大学, 人間系, 教授 (50396610)
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| Research Collaborator |
OKAWA AYUMI 鹿児島大学, 大学院・人文社会科学研究科, 大学院生
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| Project Period (FY) |
2014-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
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| Keywords | エストロゲン / 不安障害 / 産後うつ / ストレス / ホルモン / マウス / 情動 / PTSD / 恐怖学習 / 一般活動性 / 視床下部 / コルチコトロピン放出ホルモン / バソプレッシン / オキシトシン / HPA軸 / コルチコステロン / 恐怖条件づけ学習 |
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| Outline of Final Research Achievements |
Recently we demonstrated that the chronic treatment of estrogen at higher doses increased, but at lower doses decreased, emotional behavior in female mice. Estrogen is also considered to affect the activity of a hypothalamic-pituitary-adrenal (HPA) axis, and hyperactivity of the HPA axis is associated with emotional disorder. Therefore, we investigated whether disturbance of HPA axis mediates the enhancing emotional behavior by treatment of estradiol. As the results, adrenalectomy (ADX) did not prevent the effect of estradiol, the animals treated with a higher dose estradiol showed enhanced fear and anxiety-related behavior regardless of ADX. There was no clear alteration in mRNA expressions of stress-related hormones in hypothalamus of female mice which treated with various doses of estradiol. These results suggest that HPA axis might not related the estrogenic regulation of emotional behavior in that situation. Other possibilities should be investigated in the future researches.
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Effects of pre-pubertal or adult site-specific knockdown of estrogen receptor β in the medial preoptic area and medial amygdala on social behaviors in male mice2016
Author(s)
Nakata, M., Sano, K., Musatov, S., Yamaguchi, N., Sakamoto, T., and Ogawa, S.
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Journal Title
eNeuro
Volume: 3
Issue: 2
Pages: 1-14
DOI
NAID
Related Report
Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
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