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An experimental study of neuroendocrinological mechanisms underlying vulnerability to emotional disorders in pregnant and postpartum women.

Research Project

Project/Area Number 26380990
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Research Field Experimental psychology
Research InstitutionKagoshima University

Principal Investigator

TOMIHARA KAZUYA  鹿児島大学, 法文教育学域法文学系, 教授 (00272146)

Co-Investigator(Kenkyū-buntansha) 小川 園子  筑波大学, 人間系, 教授 (50396610)
Research Collaborator OKAWA AYUMI  鹿児島大学, 大学院・人文社会科学研究科, 大学院生
Project Period (FY) 2014-04-01 – 2017-03-31
Project Status Completed (Fiscal Year 2016)
Budget Amount *help
¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2016: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywordsエストロゲン / 不安障害 / 産後うつ / ストレス / ホルモン / マウス / 情動 / PTSD / 恐怖学習 / 一般活動性 / 視床下部 / コルチコトロピン放出ホルモン / バソプレッシン / オキシトシン / HPA軸 / コルチコステロン / 恐怖条件づけ学習
Outline of Final Research Achievements

Recently we demonstrated that the chronic treatment of estrogen at higher doses increased, but at lower doses decreased, emotional behavior in female mice. Estrogen is also considered to affect the activity of a hypothalamic-pituitary-adrenal (HPA) axis, and hyperactivity of the HPA axis is associated with emotional disorder. Therefore, we investigated whether disturbance of HPA axis mediates the enhancing emotional behavior by treatment of estradiol. As the results, adrenalectomy (ADX) did not prevent the effect of estradiol, the animals treated with a higher dose estradiol showed enhanced fear and anxiety-related behavior regardless of ADX. There was no clear alteration in mRNA expressions of stress-related hormones in hypothalamus of female mice which treated with various doses of estradiol. These results suggest that HPA axis might not related the estrogenic regulation of emotional behavior in that situation. Other possibilities should be investigated in the future researches.

Report

(4 results)
  • 2016 Annual Research Report   Final Research Report ( PDF )
  • 2015 Research-status Report
  • 2014 Research-status Report
  • Research Products

    (15 results)

All 2016 2015 2014

All Journal Article (4 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 3 results,  Open Access: 3 results,  Acknowledgement Compliant: 2 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] Effects of pre-pubertal or adult site-specific knockdown of estrogen receptor β in the medial preoptic area and medial amygdala on social behaviors in male mice2016

    • Author(s)
      Nakata, M., Sano, K., Musatov, S., Yamaguchi, N., Sakamoto, T., and Ogawa, S.
    • Journal Title

      eNeuro

      Volume: 3 Issue: 2 Pages: 1-14

    • DOI

      10.1523/eneuro.0155-15.2016

    • NAID

      120007135118

    • Related Report
      2016 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] 性ステロイドホルモンの中枢作用による行動調節2016

    • Author(s)
      小川 園子
    • Journal Title

      最新女性医療

      Volume: 3(2) Pages: 58-62

    • Related Report
      2016 Annual Research Report
  • [Journal Article] Effects of diethylstilbestrol exposure during gestation on both maternal and offspring behavior.2015

    • Author(s)
      Kazuya Tomihara, Takahiro Zoshiki, Sayaka Y. Kukita, Kanako Nakamura, Ayuko Isogawa, Sawako Ishibashi, Ayumi Tanaka, Ayaka S. Kuraoka and Saki Matsumoto
    • Journal Title

      Frontiers in Neuroscience

      Volume: 9

    • DOI

      10.3389/fnins.2015.00079

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 女性の情動関連障害への脆弱性に対する性腺ホルモンの関与2015

    • Author(s)
      大川あゆみ・富原一哉
    • Journal Title

      地域政策科学研究

      Volume: 12 Pages: 69-89

    • NAID

      120005600942

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 育てる脳,育てられる脳「子育て」で変わる親子の脳2016

    • Author(s)
      富原一哉
    • Organizer
      生涯学習県民大学講座
    • Place of Presentation
      かごしま県民大学中央センター(鹿児島県鹿児島市)
    • Year and Date
      2016-12-03
    • Related Report
      2016 Annual Research Report
  • [Presentation] Estrogenic modulation of wheel-running activity is independent of that of fear- and anxiety-related behavior in female mice.2016

    • Author(s)
      Kazuya Tomihara
    • Organizer
      31st International Congress of Psychology
    • Place of Presentation
      PACIFICO 横浜(神奈川県横浜市)
    • Year and Date
      2016-07-28
    • Related Report
      2016 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 雄マウスのprepulse inhibition阻害に対するエストロゲンの保護作用2015

    • Author(s)
      富原一哉,井口法子
    • Organizer
      第42回日本神経内分泌学会・第23回日本行動神経内分泌研究会合同学術集会
    • Place of Presentation
      仙台市戦災復興記念館(宮城県仙台市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] メスマウスの文脈及び手がかり恐怖条件づけ学習に対するエストロゲン処置の影響2015

    • Author(s)
      芹ヶ野優美,富原一哉
    • Organizer
      第42回日本神経内分泌学会・第23回日本行動神経内分泌研究会合同学術集会
    • Place of Presentation
      仙台市戦災復興記念館(宮城県仙台市)
    • Year and Date
      2015-09-18
    • Related Report
      2015 Research-status Report
  • [Presentation] The effects of chronic treatment of high-dose estrogen on the corticosterone concentration in serum and the mRNA expression of stress-related hormones in hypothalamus.2015

    • Author(s)
      Ayumi Okawa, Kazuya Tomihara
    • Organizer
      日本動物心理学会第75回大会
    • Place of Presentation
      日本女子大学(東京都文京区)
    • Year and Date
      2015-09-11
    • Related Report
      2015 Research-status Report
  • [Presentation] 母性阻害の神経内分泌とその適応的意義2015

    • Author(s)
      富原一哉
    • Organizer
      鹿児島神経科学研究会第6回研究発表会 特別講演
    • Place of Presentation
      鹿児島大学(鹿児島県鹿児島市)
    • Year and Date
      2015-08-08
    • Related Report
      2015 Research-status Report
    • Invited
  • [Presentation] 動物を用いた行動実験の理論と実際:行動神経内分泌学の立場から2014

    • Author(s)
      小川園子
    • Organizer
      第41回日本神経内分泌学会学術集会 神経内分泌入門 (基礎編)
    • Place of Presentation
      都道府県会館( 東京都千代田区)
    • Year and Date
      2014-11-02
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] 社会行動の性差発現を支えるホルモンの働き2014

    • Author(s)
      小川園子
    • Organizer
      第67回日本自律神経学会総会シンポジウム「内分泌機能から見た自律神経調節」
    • Place of Presentation
      ホテルラフレさいたま( 埼玉県さいたま市)
    • Year and Date
      2014-10-30
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Role of Two Types of Estrogen Receptors in Life-Long Action of Gonadal Steroids in the Regulation of Social Behavior.2014

    • Author(s)
      Sonoko Ogawa
    • Organizer
      Satellite Meeting in Sydney ICN2014, " Recent and Future Trends in Neuroendocrinology -from Asia and Oceania to Global-"
    • Place of Presentation
      Novotel Hotel Sydney Manly Pacific (Sydney, Australia)
    • Year and Date
      2014-08-16
    • Related Report
      2014 Research-status Report
    • Invited
  • [Presentation] Roles of estrogen receptor alpha and beta in regulation of emotion-related behavior by chronic treatment of estradiol in female mice.2014

    • Author(s)
      Kazuya Tomihara, Takuya Okawa
    • Organizer
      日本動物心理学会第74回大会
    • Place of Presentation
      犬山国際観光センター「フロイデ」( 愛知県犬山市)
    • Year and Date
      2014-07-19 – 2014-07-21
    • Related Report
      2014 Research-status Report
  • [Presentation] Effects of adrenalectomy on estradiol-induced enhancement of emotion-related behavior in female mice.2014

    • Author(s)
      Ayumi Ohkawa, Kazuya Tomihara
    • Organizer
      日本動物心理学会第74回大会
    • Place of Presentation
      犬山国際観光センター「フロイデ」( 愛知県犬山市)
    • Year and Date
      2014-07-19 – 2014-07-21
    • Related Report
      2014 Research-status Report

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Published: 2014-04-04   Modified: 2018-03-22  

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